Malononitrile, o-chlorobenzylidene-

RTECS #

OO3675000

CAS #

2698-41-1
See: NMAM or OSHA Methods

Updated

December 2014

Molecular Weight

188.62

Molecular Formula

C₁₀H₅ClN₂

Synonyms

(o-Chlorobenzal)malononitrile
2-Chlorobenzalmalononitrile
2-Chlorobenzylidene malononitrile
2-Chlorobmn
beta,beta-Dicyano-o-chlorostyrene
CS
NCI-C55118
o-Chlorobenzalmalononitrile
o-Chlorobenzylidene malonitrile
o-Chlorobenzylidene malononitrile
o-Chlorobenzylidene malononitrile (ACGIH:OSHA)
Propanedinitrile, ((2-chlorophenyl)methylene)
TL 238
USAF KF-11

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /guinea pig	429 ng		APTOA6 35,412,1974
eye /man	0.005 ppm/20S	severe	MMEDA9 134,219,1969
eye /man	624 ng		APTOA6 35,412,1974
eye /rabbit	5 mg		TXAPA9 4,656,1962
eye /rabbit	1 mg	mild	TXAPA9 17,295,1970
eye /rabbit	1150 ng		APTOA6 35,412,1974
skin /guinea pig	12%/6H open irritation test	mild	ARTODN 40,75,1978
skin /human	10 mg/1H	mild	BJDEAZ 90,657,1974
skin /rabbit	12%/6H open irritation test	mild	ARTODN 40,75,1978
skin /rat	12%/6H open irritation test	mild	ARTODN 40,75,1978

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	ovary/hamster	6 mg/L	NTPTR* NTP-TR-377,1990
Cytogenetic Analysis	lung/hamster	9400 nmol/L	MUREAV 282,231,1992
micronucleus test	lung/hamster	19 µmol/L	ARTODN 63,314,1989
mutation in mammalian somatic cells	lymphocyte/mouse	2500 µg/L	EMMUEG 11,91,1988
mutation in microorganisms	/Salmonella typhimurium	100 µg/plate (+/-enzymatic activation step)	ARTODN 49,15,1981
sister chromatid exchange	ovary/hamster	10 mg/L	NTPTR* NTP-TR-377,1990
sister chromatid exchange	lung/hamster	18800 nmol/L	MUREAV 282,231,1992

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	6 mg/m³/5M (6-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	37QLAZ -,79,1977

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	Lowest published lethal concentration: 2600 mg/m³/23M	Lung, Thorax, or Respiration: Other changes	FEPRA7 30(1),86,1971
inhalation/guinea pig	Lowest published lethal concentration: 2326 mg/m³/10M	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage	ARTODN 40,75,1978
inhalation/human	lowest published toxic concentration: 1500 µg/m³/90M	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Other changes	AEHLAU 6,366,1963
inhalation/mouse	Lowest published lethal concentration: 2753 mg/m³/20M	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage	ARTODN 40,75,1978
inhalation/rabbit	Lowest published lethal concentration: 1802 mg/m³/10M	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage	ARTODN 40,75,1978
inhalation/rat	Lowest published lethal concentration: 1806 mg/m³/45M	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage	ARTODN 40,75,1978
intraperitoneal/guinea pig	lethal dose (50 percent kill): 73 mg/kg	Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair	ARTODN 40,75,1978
intraperitoneal/mouse	lethal dose (50 percent kill): 32320 µg/kg	Immunological Including Allergic: Decrease in humoral immune response	TOLED5 8,73,1981
intraperitoneal/rabbit	lethal dose (50 percent kill): 32065 µg/kg	Blood: Other changes	TOXID9 3,64,1983
intraperitoneal/rat	lethal dose (50 percent kill): 48 mg/kg		TXAPA9 24,45,1973
intravenous/mouse	lethal dose (50 percent kill): 48 mg/kg		ENTOX* ,706,2005
intravenous/mouse	lethal dose (50 percent kill): 47700 µg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Other changes	TXAPA9 25,111,1973
intravenous/rabbit	lethal dose (50 percent kill): 8 mg/kg	Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Gastrointestinal: Hypermotility, diarrhea	TXAPA9 4,656,1962
intravenous/rat	lethal dose (50 percent kill): 28 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation Kidney, Ureter, and Bladder: Other changes	ARTODN 40,75,1978
oral/guinea pig	lethal dose (50 percent kill): 212 mg/kg	Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair	ARTODN 40,75,1978
oral/mouse	lethal dose (50 percent kill): 282 mg/kg		NTIS** AD837-111
oral/rabbit	lethal dose (50 percent kill): 143 mg/kg	Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair	ARTODN 40,75,1978
oral/rat	lethal dose (50 percent kill): 178 mg/kg	Gastrointestinal: Gastritis	AEHLAU 24,449,1972
subcutaneous/mouse	Lethal dose: >800 mg/kg		TXAPA9 4,656,1962

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 10 mg/m³/6H/14D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-377,1990
inhalation/mouse	lowest published toxic concentration: 3 mg/m³/6H/13W- intermittent	Olfaction: Other olfaction effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-377,1990
inhalation/rat	lowest published toxic concentration: 100 mg/m³/6H/14D- intermittent	Eye: Lacrimation Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-377,1990
inhalation/rat	lowest published toxic concentration: 1500 µg/m³/6H/13W- intermittent	Olfaction: Other olfaction effects Endocrine: Changes in thymus weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTPTR* NTP-TR-377,1990
intraperitoneal/mouse	lowest published toxic dose: 160 mg/kg/10D- intermittent	Liver: Changes in liver weight Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in humoral immune response	BECTA6 26,571,1981

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-ceiling concentration 0.05 ppm (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		CPEMM* 3,239,2002
TOXICOLOGY REVIEW		ENTOX* -,686,2005
TOXICOLOGY REVIEW		ENTOX* -,706,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		HTCWA* 2,153,
TOXICOLOGY REVIEW		CCACL* 21,719,2005
TOXICOLOGY REVIEW		NBREV* 5,1,1981
TOXICOLOGY REVIEW		TOLED5 204,148,2011

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.05 ppm (0.4 mg/m³)	DTLVS* 3,50,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	ceiling concentration 0.05 ppm (0.39 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.05 ppm (0.4 mg/m³);KZW 0.05 ppm (0.4 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.05 ppm (0.4 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	ceiling concentration 0.05 ppm (0.4 mg/m³), skin, MAY2011
Occupational Exposure Limit-FRANCE	short term exposure limit 0.05 ppm (0.4 mg/m³), Skin, FEB2006
Occupational Exposure Limit-ICELAND	short term exposure limit 0.05 ppm (0.4 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	ceiling concentration 0.05 ppm (0.4 mg/m³), 2006
Occupational Exposure Limit-MEXICO	peak 0.5 ppm (0.4 mg/m³) (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	ceiling concentration 0.05 ppm (0.39 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.05 ppm (0.4 mg/m³), JAN1999
Occupational Exposure Limit-PERU	short term exposure limit 0.05 ppm (0.39 mg/m³), JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.05 ppm (0.4 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-C 0.4 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 05 ppm (0.4 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.05 ppm (0.4 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.05 ppm (0.4 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.05 ppm (0.4 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.05 ppm (0.4 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-CHLOROBENZYLIDENEMALONONITRILE-air	ceiling concentration 0.05 ppm (Sk)	NIOSH* DHHS #95-121,1995

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health