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Registry of Toxic Effects of Chemical Substances (RTECS)

Malononitrile

RTECS #

OO3150000

CAS #

109-77-3

Updated

July 2016

Molecular Weight

66.07

Molecular Formula

C3H2N2

Synonyms

Cyanoacetonitrile
Dicyanomethane
Dwumetylosulfotlenku (Polish)
Malonic acid dinitrile
Malonic dinitrile
Methane, dicyano-
Methylene cyanide
Nitril kyseliny malonove (Czech)
Propanedinitrite
RCRA waste number U149
USAF A-4600
USAF KF-19

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 mg/24H severe85JCAE -,899,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 24.1 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
intraperitoneal/mouse lethal dose (50 percent kill): 13 mg/kgBehavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
NATUAS 228,1315,1970
intraperitoneal/rabbit lethal dose (50 percent kill): 10043 µg/kgBlood: Other changesTOXID9 3,64,1983
intraperitoneal/rat lethal dose (50 percent kill): 20550 µg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
MEPAAX 27,1,1976
intraperitoneal/rat lethal dose (50 percent kill): 41.9 mg/kg/24HBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression
FCTOD7 59,595,2013
intravenous/mouse lethal dose (50 percent kill): 32 mg/kgCSLNX* NX#07576
intravenous/rabbit lethal dose (50 percent kill): 28 mg/kgPJPPAA 31,563,1979
oral/mouse lethal dose (50 percent kill): 19 mg/kgKHZDAN 9,50,1966
oral/rat lethal dose (50 percent kill): 66.4 mg/kg/24HBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression
FCTOD7 59,595,2013
oral/rat lethal dose (50 percent kill): 14 mg/kgNTIS** OTS0526327
oral/rat lethal dose (50 percent kill): 69.8 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 47,2314,2009
skin/rat lethal dose (50 percent kill): 350 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
MEPAAX 27,1,1976
subcutaneous/Dog lowest published lethal dose: 6500 µg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
AIPTAK 3,77,1897
subcutaneous/frog lowest published lethal dose: 95 mg/kgAIPTAK 3,77,1897
subcutaneous/guinea pig lethal dose (50 percent kill): 21 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
MEPAAX 27,1,1976
subcutaneous/mouse lowest published lethal dose: 8 mg/kgAIPTAK 3,77,1897
subcutaneous/pigeon lowest published lethal dose: 80 mg/kgAIPTAK 3,77,1897
subcutaneous/rabbit lowest published lethal dose: 6 mg/kgCRSBAW 96,202,1927
subcutaneous/rat lethal dose (50 percent kill): 31500 µg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
MEPAAX 27,1,1976
subcutaneous/rat lethal dose (50 percent kill): 47.6 mg/kg/24HBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression
FCTOD7 59,595,2013

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 28500 mg/kg/19W- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
KHZDAN 15,553,1972
oral/rat lowest published toxic dose: 164 mg/kg/28D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTIS** OTS0526327

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MALONONITRILE-air10H time-weighted average 3 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X5636; Number of Industries 1; Total Number of Facilities 4; Number of Occupations 15; Total Number of Employees Exposed 1233

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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