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Registry of Toxic Effects of Chemical Substances (RTECS)

Lactic acid, butyl ester

RTECS #

OD4025000

CAS #

138-22-7

Updated

September 2013

Molecular Weight

146.21

Molecular Formula

C7H14O3

Synonyms

Butyl 2-hydroxypropanoate
Butyl alpha-hydroxypropionate
Butyl lactate
Butylester kyseliny mlecne (Czech)
n-Butyl lactate
n-Butyl lactate (ACGIH)
Propanoic acid, 2-hydroxy-, butyl ester (9CI)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H moderateFCTXAV 17,727,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >5.14 gm/m3/4HFEREAC 67,56225,2002
oral/rabbit lethal dose (50 percent kill): >5 gm/kgIJTOFN 17(Suppl 1),71,1998
oral/rat lethal dose (50 percent kill): >2000 mg/kgFEREAC 67,56225,2002
skin/rabbit lethal dose (50 percent kill): >5 gm/kgFCTXAV 17,727,1979
skin/rat lethal dose (50 percent kill): >5000 mg/kgFEREAC 69,34945,2004
subcutaneous/mouse lowest published lethal dose: 11 gm/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
FCTXAV 17,727,1979
subcutaneous/rat lethal dose (50 percent kill): 12 gm/kgNPIRI* 1,15,1974

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 ppm (5 mg/m3)DTLVS* 3,33,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 ppm (30 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (30 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (30 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (30 mg/m3), short term exposure limit 10 ppm (61 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 5 ppm (25 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (30 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (25 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 ppm (25 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (30 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (30 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 5 ppm (30 mg/m3);short term exposure limit 10 ppm (60 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (30 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 20 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 ppm (30 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-BUTYL LACTATE-air10H time-weighted average 5 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M1128; Number of Industries 9; Total Number of Facilities 170; Number of Occupations 15; Total Number of Employees Exposed 5342; Total Number of Female Employees Exposed 1381
National Occupational Hazard Survey 1974Hazard Code M1128; Number of Industries 8; Total Number of Facilities 242; Number of Occupations 10; Total Number of Employees Exposed 3107

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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