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Registry of Toxic Effects of Chemical Substances (RTECS)

Isopropyl alcohol

RTECS #

NT8050000

CAS #

67-63-0; 8013-70-5

Updated

October 2016

Molecular Weight

60.11

Molecular Formula

C3H8O

Synonyms

1-Methylethanol
1-Methylethyl alcohol
2-Hydroxypropane
2-Propanol
2-Propyl alcohol
Alcojel
Alcool isopropilico (Italian)
Alcool isopropylique (French)
Alcosolve
Avantin
Avantine
Combi-schutz
Dimethylcarbinol
Hartosol
Imsol A
i-Propanol (German)
i-Propylalkohol (German)
IPS 1 (alcohol)
Isohol
Isopropanol
Isopropyl alcohol (ACGIH:OSHA)
Iso-propylalkohol (German)
Lutosol
n-Propan-2-ol
Petrohol
PRO
sec-Propyl alcohol
Spectrar
Sterisol hand disinfectant
Takineocol
Virahol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeAJOPAA 29,1363,1946
eye /rabbit 10 mg moderateTXAPA9 55,501,1980
eye /rabbit 100 mg/24H moderate85JCAE -,191,1986
skin /rabbit 500 mg mildNTIS** AD-A106-944

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisinhalation/rat1030 µg/m3/16W- intermittentGTPZAB 25(7),33,1981
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster25 pphMUREAV 726,215,2011
specific locus testinhalation/Drosophila melanogaster50 pphMUREAV 726,215,2011

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 3500 ppm/7H (1-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FCTOD7 26,247,1988
inhalation/rat 10000 ppm/7H (1-19D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
FCTOD7 26,247,1988
inhalation/rat 7000 ppm/7H (1-19D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFCTOD7 26,247,1988
oral/rabbit 6240 mg/kg (6-18D pregnant)Reproductive: Other effects on femaleFAATDF 22,139,1994
oral/rat 3276 mg/kg (182D prior to copulation)Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVGK* -,98,1994
oral/rat 2278 mg/kg (6-16D pregnant)Reproductive: Other effects on female

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
BDERB* 83,459,2008
oral/rat 11340 mg/kg (45D prior to copulation)Reproductive: Maternal effects: Menstrual cycle changes or disordersGISAAA 43(1),8,1978
oral/rat 5040 mg/kg (1-20D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)GISAAA 43(1),8,1978
oral/rat 8 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)RTOPDW 23,183,1996
oral/rat 32400 µg/kg (26W prior to copulation)Reproductive: Effects on embryo or fetus: Fetal deathGISAAA 43(1),8,1978
oral/rat 3500 gm/kg (multigeneration)Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)TOXID9 13,75,1993

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 394389 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 44999 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 344989 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 68128 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Hamster, lung fibroblast Inhibitor Concentration (50 percent kill): 84 mmol/L/60HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,511,1993
In Vitro/Hamster, lung fibroblast Inhibitor Concentration (10 percent kill): 11.5 mmol/L/60HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,511,1993
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: >104 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Human, HeLa cell Inhibitor Concentration (50 percent kill): 700.5 mmol/L/60HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,511,1993
In Vitro/Human, HeLa cell Inhibitor Concentration (10 percent kill): 6.5 mmol/L/60HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,511,1993
In Vitro/Human, kidney tumor Inhibitor Concentration (50 percent kill): 45500 mg/LIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 27,1347,2013
In Vitro/Human, leukemia cells Inhibitor Concentration (5 percent kill): >25000 mg/L/30MIn Vitro Toxicity Studies: Cell countingTIVIEQ 27,857,2013
In Vitro/Human, liver Inhibitor Concentration (50 percent kill): 49 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Human, liver tumor Inhibitor Concentration Low: >91 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 256 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 4830 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1347,2013
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 39700 mg/LIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 27,1347,2013
In Vitro/Human, monocyte Inhibitor Concentration (20 percent kill): >10000 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 199,51,2010
In Vitro/Human, monocyte Inhibitor Concentration (20 percent kill): 10 mmol/L/2HIn Vitro Toxicity Studies: Other assaysTOLED5 199,51,2010
In Vitro/Human, neuroblastoma Inhibitor Concentration (20 percent kill): 12 mmol/L/30MIn Vitro Toxicity Studies: Other assaysTXAPA9 245,191,2010
In Vitro/Human, neuroblastoma Inhibitor Concentration (50 percent kill): 2480 mg/LIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 27,1347,2013
In Vitro/Human, skin Inhibitor Concentration (20 percent kill): 15.0 mg/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,314,2013
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): >2000 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 245,281,2010
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 4660 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1347,2013
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 109000 mg/L/1MIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,367,1992
In Vitro/jdaInhibitor Concentration (50 percent kill): 401672 mg/L/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 212,198,2012
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 48 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 3950 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1347,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration Low: >104 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 414 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 5,449,1991
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 184 mmol/L/72HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 5,449,1991
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 523 mmol/L/48HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 5,449,1991
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 300 mmol/L/72HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 5,449,1991
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 400 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 5,449,1991
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 326 mmol/L/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 5,449,1991
In Vitro/Mouse, liver Inhibitor Concentration (50 percent kill): 520 mmol/L/2HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TIVIEQ 4,783,1990
In Vitro/Mouse, macrophage Inhibitor Concentration Low: >104 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/mraInhibitor Concentration (25 percent kill): 5000 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 216,65,2013
In Vitro/mraInhibitor Concentration Low: 2500 mg/L/24HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTOLED5 216,65,2013
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 568 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
In Vitro/paaInhibitor Concentration Low: 28.6 mmol/L/44HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1416,2013
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 41 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 14600 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1347,2013
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 10.9 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 8.1 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 6.03 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 15.9 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 5.6 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 10.2 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,111,1993
inhalation/guinea pig lowest published toxic concentration: 980 mg/m3/24HEar: Tumors

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes
VCVGK* -,97,1984
inhalation/human lowest published toxic concentration: 35 ppm/4HCardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes
NRTXDN 24,179,2003
inhalation/human lowest published toxic concentration: 150 ppm/2HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesTOXID9 60,428,2001
inhalation/mouse lowest published toxic concentration: 3000 ppm/6MLung, Thorax, or Respiration: Respiratory depressionTOLED5 9,137,1981
inhalation/mouse lethal concentration (50 percent kill): 53000 mg/m3Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes
VCVGK* -,97,1984
inhalation/mouse Lowest published lethal concentration: 12800 ppm/3HIAEC** 17JUN1974
inhalation/rat lethal concentration (50 percent kill): 16000 ppm/8HNPIRI* 1,100,1974
inhalation/rat lethal concentration (50 percent kill): 72600 mg/m3Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes
VCVGK* -,97,1984
intraperitoneal/guinea pig lethal dose (50 percent kill): 2560 mg/kgEVHPAZ 61,321,1985
intraperitoneal/hamster lethal dose (50 percent kill): 3444 mg/kgEVHPAZ 61,321,1985
intraperitoneal/mouse lethal dose (50 percent kill): 4477 mg/kgEVHPAZ 61,321,1985
intraperitoneal/rabbit lethal dose (50 percent kill): 667 mg/kgEVHPAZ 61,321,1985
intraperitoneal/rat lowest published toxic dose: 800 mg/kgBehavioral: AtaxiaVCVGK* -,97,1984
intraperitoneal/rat lethal dose (50 percent kill): 2735 mg/kgEVHPAZ 61,321,1985
intravenous/cat lowest published lethal dose: 1963 mg/kgHBTXAC 1,172,1955
intravenous/Dog lowest published lethal dose: 1024 mg/kgJLCMAK 29,561,1944
intravenous/mouse lethal dose (50 percent kill): 1509 mg/kgENTOX* ,706,2005
intravenous/rabbit lethal dose (50 percent kill): 1184 mg/kgEVHPAZ 61,321,1985
intravenous/rat lethal dose (50 percent kill): 1088 mg/kgEVHPAZ 61,321,1985
oral/cat lowest published lethal dose: 6 mL/kgAIPTAK 26,285,1921
oral/Dog lowest published lethal dose: 1537 mg/kgGastrointestinal: Nausea or vomitingJLCMAK 29,561,1944
oral/human lowest published lethal dose: 3570 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Nausea or vomiting
34ZIAG -,339,1969
oral/human lowest published toxic dose: 223 mg/kgBehavioral: Hallucinations, distorted perceptions

Cardiac: Pulse rate decreased with fall in BP

Vascular: BP lowering not characterized in autonomic section
JLCMAK 12,326,1927
oral/human lowest published toxic dose: 286 mg/kgCardiac: Arrythmias (indlucing changes in conduction)

Behavioral: Coma

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,97,1984
oral/human lowest published lethal dose: 571 mL/kgVCVGK* -,97,1984
oral/infant lowest published toxic dose: 13 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Irritability

Gastrointestinal: Nausea or vomiting
AJEMEN 10,542,1992
oral/man lowest published lethal dose: 5272 mg/kgBehavioral: Coma

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
AJCPAI 38,144,1962
oral/man lowest published toxic dose: 14432 mg/kgBehavioral: Coma

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Dyspnea
NEJMAG 277,699,1967
oral/mouse lethal dose (50 percent kill): 3600 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)
GISAAA 43(1),8,1978
oral/mouse lethal dose (50 percent kill): 3600 mg/kgBehavioral: General anestheticVCVGK* -,97,1984
oral/rabbit lethal dose (50 percent kill): 6410 mg/kgFAONAU 48A,114,1970
oral/rat lethal dose (50 percent kill): 5000 mg/kgBehavioral: General anestheticVCVGK* -,97,1984
oral/rat lethal dose (50 percent kill): 5045 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)
GISAAA 43(1),8,1978
parenteral/frog lowest published lethal dose: 20 gm/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)
AIPTAK 50,296,1935
skin/rabbit lethal dose (50 percent kill): 12800 mg/kgNPIRI* 1,100,1974
subcutaneous/mammal (species unspecified) lowest published lethal dose: 6 gm/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes
ATXKA8 16,84,1956
subcutaneous/mouse lowest published lethal dose: 6 gm/kgHBTXAC 1,172,1955
unreported route/human lowest published lethal dose: 2 mL/kgJJTOEX 12,341,1999
unreported route/infant lowest published toxic dose: 1375 mg/kgEye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Hallucinations, distorted perceptions
PECAE5 9,146,1993
unreported route/man lowest published lethal dose: 2770 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 5000 ppm/6H/13W- intermittentBehavioral: General anesthetic

Behavioral: Ataxia

Liver: Changes in liver weight
RTOPDW 23,183,1996
inhalation/mouse lowest published toxic concentration: 5000 ppm/6H/78W- intermittentBrain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
RTOPDW 23,183,1996
inhalation/mouse lowest published toxic concentration: 10000 ppm/6H/11D- intermittentBehavioral: General anesthetic

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0522901-2
inhalation/mouse lowest published toxic concentration: 5000 ppm/6H/13W- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells
NTIS** OTS0529356
inhalation/rat lowest published toxic concentration: 100 mg/m3/4H/17W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GTPZAB 29(7),60,1985
inhalation/rat lowest published toxic concentration: 8000 ppm/8H/20W- intermittentPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Peripheral Nerve and Sensation: Recording from peripheral motor nerve
ENVRAL 62,148,1993
inhalation/rat lowest published toxic concentration: 5000 ppm/6H/90D- intermittentBehavioral: Change in motor activity (specific assay)TOXID9 14,97,1994
inhalation/rat lowest published toxic concentration: 2500 ppm/6H/2Y- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in bladder weight
TOXID9 15,183,1995
inhalation/rat lowest published toxic concentration: 4900 mg/m3/6H/2W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effectsVCVGK* -,97,1994
inhalation/rat lowest published toxic concentration: 1000 mg/m3/6H/4W- intermittentEye: Optic nerve neuropathyVCVGK* -,97,1994
inhalation/rat lowest published toxic concentration: 500 mg/m3/4H/122D- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,98,1994
inhalation/rat lowest published toxic concentration: 20 mg/m3/24H/90D- continuousBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Liver: Multiple effects
VCVGK* -,98,1994
oral/rat lowest published toxic dose: 2196 mg/kg/122D- intermittentEndocrine: Effect on menstrual cycleVCVGK* -,98,1994
oral/rat lowest published toxic dose: 2196 mg/kg/122D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)VCVGK* -,98,1994
oral/rat lowest published toxic dose: 7 mL/kg/7D- intermittentLiver: Other changes

Biochemical: Effect on specific coenzyme: B vitamins including folate
JDGRAX 10(1-2),25,1978
oral/rat lowest published toxic dose: 11340 mg/kg/45D- intermittentEndocrine: Effect on menstrual cycleVCVGK* -,98,1994
oral/rat lowest published toxic dose: 7000 mg/kg/7D- intermittentLiver: Other changesTXCYAC 303,133,2013

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 200 ppm;short term exposure limit 400 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 15,223,1977
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 71,1027,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMSUDL 7,229,1987
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 71,1027,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1027,1999
TOXICOLOGY REVIEWJIHTAB 20,428,1938
TOXICOLOGY REVIEWCLCHAU 19,361,1973
TOXICOLOGY REVIEWFNSCA6 2,67,1973
TOXICOLOGY REVIEWTOLED5 140-141,239,2003
TOXICOLOGY REVIEWTOLED5 140-141,261,2003
TOXICOLOGY REVIEWAJINC* 34,627,2006
TOXICOLOGY REVIEWAJEMEN 22,404,2004
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWHUTOX* -,623,1996
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNTAPM* -,727,1995
TOXICOLOGY REVIEWREPTED 32,142,2011
TOXICOLOGY REVIEWTOLED5 210,44,2012
TOXICOLOGY REVIEWMUREAV 768,27,2016

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,290,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 400 ppm (980 mg/m3)DTLVS* 3,141,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 400 ppm (983 mg/m3), short term exposure limit 500 ppm (1230 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 200 ppm (500 mg/m3);KZW 800 ppm (2000 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 400 ppm (997 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 500 ppm (1248 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 200 ppm (490 mg/m3), MAY2011
Occupational Exposure Limit-FRANCEVLE 400 ppm (980 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 200 ppm (500 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 500 mg/m3, short term exposure limit 2000 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 200 ppm (490 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANceiling concentration 400 ppm (980 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 400 ppm (980 mg/m3), short term exposure limit 500 ppm (1225 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 400 ppm (980 mg/m3);short term exposure limit 500 ppm (1225 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 400 ppm (983 mg/m3); short term exposure limit 500 ppm (1230 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 200 ppm (491 mg/m3); short term exposure limit 400 ppm (983 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 900 mg/m3, MAC(short term exposure limit) 1200 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 10 mg/m3, short term exposure limit 50 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 150 ppm (350 mg/m3);short term exposure limit 250 ppm (600 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 200 ppm (500 mg/m3), KZG-week 400 ppm (1000 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 650 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 400 ppm (980 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 200 ppm (500 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 400 ppm (999 mg/m3);short term exposure limit 500 ppm (1250 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 400 ppm (980 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 400 ppm (980 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 400 ppm (980 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 400 ppm (980 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOPROPYL ALCOHOL-air10H time-weighted average 400 ppm;short term exposure limit 500 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 40987; Number of Industries 449; Total Number of Facilities 183402; Number of Occupations 278; Total Number of Employees Exposed 4665524; Total Number of Female Employees Exposed 2058264
National Occupational Hazard Survey 1974Hazard Code 40987; Number of Industries 465; Total Number of Facilities 213605; Number of Occupations 252; Total Number of Employees Exposed 3183554

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; N crassa-aneuploidy
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8734;8EHQ-0892-8787
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols I, 1400
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
OSHA ANALYTICAL METHOD #109
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