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Registry of Toxic Effects of Chemical Substances (RTECS)

Isocyanic acid, methylenedi-4,1-cyclohexylene ester

RTECS #

NQ9250000

CAS #

5124-30-1

Updated

September 2013

Molecular Weight

262.39

Molecular Formula

C15H22N2O2

Synonyms

4,4'-Diisocyanatodicyclohexylmethane
Bis(4-isocyanatocyclohexyl)methane
CP 99173
Cyclohexane, 1,1'-methylenebis(4-isocyanato- (9CI)
Dicyclohexylmethane-4,4'-diisocyanate
Hydrogenated MDI
Hylene W
Methylene bis-(4-cyclohexylisocyanate)
Methylene bis(4-cyclohexylisocyanate)
Methylene bis(4-cyclohexylisocyanate) (ACGIH)
Nacconate H 12

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL mildNTIS** OTS0530188
eye /rabbit 100 µL/24H severeNTIS** OTS0555173
skin /rabbit 500 µL/24H moderateNTIS** OTS0555173

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lethal concentration (50 percent kill): 51 mg/m3/1HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0534736
inhalation/rat Lowest published lethal concentration: 431 mg/m3/4HARTODN 78,243,2004
inhalation/rat Lowest published lethal concentration: 20 ppm/5H85INA8 6,998,1991
oral/rat lethal dose (50 percent kill): 9900 mg/kgBehavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea

Liver: Other changes
NTIS** OTS000555173
skin/rabbit Lethal dose: >10 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Muscle weakness
NTIS** OTS0555173

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 220 mg/kg/12D- intermittentSkin: After topical application: Cutaneous sensitization (experimental)

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 207,487,2005
skin/mouse lowest published toxic dose: 280 mg/kg/14D- intermittentImmunological Including Allergic: Increase in humoral responseTOSCF2 94,108,2006
skin/mouse lowest published toxic dose: 480 mg/kg/28D- intermittentLung, Thorax, or Respiration: Other changesTOSCF2 94,108,2006

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.005 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 140-141,213,2003

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.005 ppm (0.054 mg/m3);KZW 0.005 ppm (0.054 mg/m3), skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.005 ppm (0.055 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.005 ppm (0.054 mg/m3), MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.005 ppm (0.054 mg/m3), NOV2011
Occupational Exposure Limit-MEXICOtime-weighted average 0.01 ppm (0.11 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.02 mg(NCO)/m3; short term exposure limit 0.07 mg(NCO)/m3, sen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.005 ppm (0.05 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,005 ppm (0,054 mg/m3), JUL2005
Occupational Exposure Limit-THE NETHERLANDSMAC-C 0.1 1 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICYCLOHEXYLMETHANE 4,4'-DIISOCYANATE-airceiling concentration 0.01 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X1175; Number of Industries 16; Total Number of Facilities 624; Number of Occupations 18; Total Number of Employees Exposed 7764; Total Number of Female Employees Exposed 637
National Occupational Hazard Survey 1974Hazard Code M1655; Number of Industries 6; Total Number of Facilities 102; Number of Occupations 22; Total Number of Employees Exposed 4022

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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