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Registry of Toxic Effects of Chemical Substances (RTECS)

Isobutyl alcohol

RTECS #

NP9625000

CAS #

78-83-1

Updated

October 2017

Molecular Weight

74.14

Molecular Formula

C4H10O

Synonyms

1-Hydroxymethylpropane
1-Propanol, 2-methyl-
2-Methyl propanol
2-Methyl-1-propanol
2-Methylpropan-1-ol
2-Methylpropyl alcohol
Alcool isobutylique (French)
Fermentation butyl alcohol
Isobutanol
Isobutyl alcohol (ACGIH:OSHA)
Isobutylalkohol (Czech)
Isopropylcarbinol
RCRA waste number U140

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Escherichia coli25000 ppm (-enzymatic activation step)ABMGAJ 23,843,1969

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 10000 mg/m3 (6-15D pregnant)Reproductive: Other effects on femaleHPV357 -,-,2006
inhalation/rabbit 10000 mg/m3 (7-19D pregnant)Reproductive: Other effects on femaleHPV357 -,-,2006

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 29 gm/kg/71W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Blood: Leukemia
ARGEAR 45,19,1975
subcutaneous/rat lowest published toxic dose: 9 gm/kg/78W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
ARGEAR 45,19,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
eye/human lowest published toxic dose: 72.5 mg/m3Eye: Conjunctiva irritationVCVGK* -,103,1984
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 77 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Rabbit, ocular Inhibitor Concentration Low: 5 pph/5MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1855,2013
inhalation/guinea pig lethal concentration (50 percent kill): 19900 mg/m3/4HVCVGK* -,102,1984
inhalation/mammal (species unspecified) lowest published toxic concentration: 15.7 mg/m3/4HBrain and Coverings: Other degenerative changes

Liver: Multiple effects

Endocrine: Evidence of thyroid hyperfunction
VCVGK* -,102,1984
inhalation/mouse lowest published toxic concentration: 700 ppm/6MLung, Thorax, or Respiration: Respiratory depressionTOLED5 9,137,1981
inhalation/mouse lethal concentration (50 percent kill): 15500 mg/m3/2HVCVGK* -,102,1984
inhalation/rabbit lethal concentration (50 percent kill): 2630 mg/m3/4HVCVGK* -,102,1984
inhalation/rat lethal concentration (50 percent kill): 19200 mg/m3/4HVCVGK* -,102,1984
inhalation/rat Lowest published lethal concentration: 8000 mg/m3/4HVCVGK* -,102,1984
inhalation/rat Lowest published lethal concentration: 8000 ppm/4HAMIHBC 10,61,1954
intraperitoneal/guinea pig lethal dose (50 percent kill): 1201 mg/kgEVHPAZ 61,321,1985
intraperitoneal/hamster lethal dose (50 percent kill): 1401 mg/kgEVHPAZ 61,321,1985
intraperitoneal/mouse lethal dose (50 percent kill): 544 mg/kgLiver: Other changesRCOCB8 26,75,1979
intraperitoneal/mouse lethal dose (50 percent kill): 544 mg/kgVCVGK* -,102,1984
intraperitoneal/rabbit lethal dose (50 percent kill): 323 mg/kgEVHPAZ 61,321,1985
intraperitoneal/rat lethal dose (50 percent kill): 720 mg/kgEVHPAZ 61,321,1985
intravenous/cat lowest published lethal dose: 180 mg/kgVCVGK* -,102,1984
intravenous/mouse lethal dose (50 percent kill): 417 mg/kgEVHPAZ 61,321,1985
intravenous/rat lethal dose (50 percent kill): 340 mg/kgEVHPAZ 61,321,1985
oral/human lowest published lethal dose: 428 mg/kgVCVGK* -,103,1984
oral/mouse lethal dose (50 percent kill): 3500 mg/kgVCVGK* -,102,1984
oral/rabbit lethal dose (50 percent kill): 74.1 mg/kgVCVGK* -,102,1984
oral/rabbit lowest published lethal dose: 3750 mg/kgVCVGK* -,102,1984
oral/rabbit lowest published lethal dose: 3750 mg/kgBehavioral: General anestheticJLCMAK 10,985,1925
oral/rat lethal dose (50 percent kill): 2460 mg/kgAMIHBC 10,61,1954
skin/rabbit lethal dose (50 percent kill): 3400 mg/kgNPIRI* 1,11,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1500 ppm/6H/2W- intermittentBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0558856
inhalation/rat lowest published toxic concentration: 0.5 mg/m3/122D- continuousLung, Thorax, or Respiration: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,103,1994
oral/rat lowest published toxic dose: 93 gm/kg/13W- intermittentBehavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Changes in: K

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0531063

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWREPTED 58,252,2015
TOXICOLOGY REVIEWFCTOD7 97,S157,I2

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (300 mg/m3)DTLVS* 3,140,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (152 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (154 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 50 ppm (150 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm (150 mg/m3), short term exposure limit 75 ppm (230 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 50 ppm (150 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 100 ppm (310 mg/m3), 2011
Occupational Exposure Limit-ICELANDshort term exposure limit 50 ppm (150 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 50 ppm (150 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (150 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (150 mg/m3);short term exposure limit 75 ppm (225 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (152 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (152 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 200 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 50 ppm (150 mg/m3);short term exposure limit 75 ppm (250 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 50 ppm (150 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 150 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 50 ppm (154 mg/m3);short term exposure limit 75 ppm (231 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (300 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (300 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (300 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (300 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOBUTYL ALCOHOL-air10H time-weighted average 50 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 40430; Number of Industries 155; Total Number of Facilities 15449; Number of Occupations 99; Total Number of Employees Exposed 256975; Total Number of Female Employees Exposed 49376
National Occupational Hazard Survey 1974Hazard Code 40430; Number of Industries 181; Total Number of Facilities 16985; Number of Occupations 98; Total Number of Employees Exposed 107310

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols II, 1401
On EPA IRIS database
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