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Registry of Toxic Effects of Chemical Substances (RTECS)

Iodine

RTECS #

NN1575000

CAS #

7553-56-2

Updated

September 2013

Molecular Weight

253.80

Molecular Formula

I2

Synonyms

IODE (French)
Iodine (ACGIH:OSHA)
Iodine crystals
Iodine sublimed
Iodio (Italian)
Jod (German, Polish)
Jood (Dutch)

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1100 mg/kg (1-22D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)JONUAI 84,107,1964
oral/rat 2750 mg/kg (1-22D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)JONUAI 84,107,1964
oral/rabbit 15 mg/kg (30-31D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JONUAI 87,394,1965

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 1 mg/m3Behavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVN5* -,400,1989
inhalation/mammal (species unspecified) lowest published toxic concentration: 100 mg/m3Endocrine: Other changesVCVN5* -,399,1989
inhalation/mammal (species unspecified) lowest published toxic concentration: 10 mg/m3Lung, Thorax, or Respiration: CoughVCVN5* -,399,1989
inhalation/rat lowest published toxic concentration: 100 mg/m3Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
VCVN5* -,399,1989
inhalation/rat Lowest published lethal concentration: 137 ppm/1HEye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Body temperature decrease
NTIS** OTS0555278
intravenous/Dog lowest published lethal dose: 40 mg/kgHBTXAC 5,76,1959
oral/Dog lowest published lethal dose: 800 mg/kgHBAMAK 4,1289,1935
oral/human lowest published lethal dose: 28 mg/kgGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
34ZIAG -,330,1969
oral/human lowest published toxic dose: 0.07 gm/kgBehavioral: Muscle weakness

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed
VCVN5* -,400,1989
oral/human lowest published toxic dose: 25 mg/kgLung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
VCVN5* -,400,1989
oral/mouse lethal dose (50 percent kill): 1000 mg/kgBehavioral: Change in motor activity (specific assay)VCVN5* -,399,1989
oral/mouse lethal dose (50 percent kill): 22 gm/kgDRFUD4 4,876,1979
oral/rabbit lethal dose (50 percent kill): 10 gm/kgDRFUD4 4,876,1979
oral/rabbit lowest published lethal dose: 5 mg/kgBlood: Other hemolysis with or without anemiaVCVN5* -,399,1989
oral/rat lethal dose (50 percent kill): 14 gm/kgDRFUD4 4,876,1979
oral/woman lowest published toxic dose: 26 mg/kg/1Y- intermittentEndocrine: Evidence of thyroid hyperfunctionPGMJAO 62,661,1986
subcutaneous/mouse lethal dose (50 percent kill): >8650 mg/kgNIIRDN -,1226,1990
subcutaneous/rabbit lowest published lethal dose: 175 mg/kgHBTXAC 5,76,1959
subcutaneous/rat lethal dose (50 percent kill): 10500 mg/kgNIIRDN -,1226,1990
unreported route/man lowest published lethal dose: 29 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 0.5 mg/m3/24H/8W- continuousOlfaction: Change in sensation of smellVCVN5* -,400,1989
inhalation/rat lowest published toxic concentration: 3.1 mg/m3/24H/13W- continuousLiver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed

Endocrine: Other changes
VCVN5* -,400,1989
inhalation/rat lowest published toxic concentration: 1.38 mg/m3/24H/13W- continuousBehavioral: Change in motor activity (specific assay)

Behavioral: Aggression
VCVN5* -,400,1989
oral/rat lowest published toxic dose: 746 mg/kg/14W- continuousBlood: Other changesJTEHD6 32,89,1991
oral/woman lowest published toxic dose: 864 mg/kg/26W- intermittentEndocrine: Evidence of thyroid hyperfunction

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCLPH* 23(Suppl 1),103,2009

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 ppm (inhal, vapor)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFOREAE 7,313,1942
TOXICOLOGY REVIEWKOTTAM 11,1300,1975
TOXICOLOGY REVIEWHUTOX* -,661,1996
TOXICOLOGY REVIEWHTOPA* 1,595,2002

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,258,1998
Mine Safety and Health Administration (MSHA) STANDARDair-ceiling concentration 0.1 ppm (1 mg/m3)DTLVS* 3,135,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 ppm (0.1 mg/m3), JAN1993
Occupational Exposure Limit-AUSTRALIAceiling concentration 0.1 ppm (1 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 ppm (1 mg/m3);KZW 0.1 ppm (1 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (1 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 0.1 ppm (1 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 0.1 ppm (1.1 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVLE 0.1 ppm (1 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg/m3, short term exposure limit 1 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDshort term exposure limit 0.1 ppm (1 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 ppm (1 mg/m3), s2 sen, MAY2012
Occupational Exposure Limit-KOREAceiling concentration 0.1 ppm (1 mg/m3), 2006
Occupational Exposure Limit-MEXICOpeak 0.1 ppm (1 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 0.1 ppm (1 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 ppm (1 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average short term exposure limit 0,1 ppm (1 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENceiling concentration 0.1 ppm (1 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.1 ppm (1 mg/m3), sen, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 ppm (1 mg/m3), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-C 1 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 ppm (1 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 ppm (1 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMshort term exposure limit 0.1 ppm (1.1 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 0.1 ppm (1 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 0.1 ppm (1 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 0.1 ppm (1 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 0.1 ppm (1 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IODINE-airceiling concentration 0.1 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 40030; Number of Industries 63; Total Number of Facilities 6179; Number of Occupations 77; Total Number of Employees Exposed 204902; Total Number of Female Employees Exposed 129889
National Occupational Hazard Survey 1974Hazard Code 40030; Number of Industries 51; Total Number of Facilities 7490; Number of Occupations 46; Total Number of Employees Exposed 124917

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Iodine, 6005
OSHA ANALYTICAL METHOD #ID-177
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