Iodine

RTECS #

NN1575000

CAS #

7553-56-2
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

253.80

Molecular Formula

I₂

Synonyms

IODE (French)
Iodine (ACGIH:OSHA)
Iodine crystals
Iodine sublimed
Iodio (Italian)
Jod (German, Polish)
Jood (Dutch)

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	1100 mg/kg (1-22D pregnant)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	JONUAI 84,107,1964
oral/rat	2750 mg/kg (1-22D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	JONUAI 84,107,1964
oral/rabbit	15 mg/kg (30-31D pregnant)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	JONUAI 87,394,1965

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 1 mg/m³	Behavioral: Muscle weakness Behavioral: Coma Lung, Thorax, or Respiration: Acute pulmonary edema	VCVN5* -,400,1989
inhalation/mammal (species unspecified)	lowest published toxic concentration: 100 mg/m³	Endocrine: Other changes	VCVN5* -,399,1989
inhalation/mammal (species unspecified)	lowest published toxic concentration: 10 mg/m³	Lung, Thorax, or Respiration: Cough	VCVN5* -,399,1989
inhalation/rat	lowest published toxic concentration: 100 mg/m³	Eye: Lacrimation Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Body temperature decrease	VCVN5* -,399,1989
inhalation/rat	Lowest published lethal concentration: 137 ppm/1H	Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Nutritional and Gross Metabolic: Body temperature decrease	NTIS** OTS0555278
intravenous/Dog	lowest published lethal dose: 40 mg/kg		HBTXAC 5,76,1959
oral/Dog	lowest published lethal dose: 800 mg/kg		HBAMAK 4,1289,1935
oral/human	lowest published lethal dose: 28 mg/kg	Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Other changes	34ZIAG -,330,1969
oral/human	lowest published toxic dose: 0.07 gm/kg	Behavioral: Muscle weakness Gastrointestinal: Nausea or vomiting Kidney, Ureter, and Bladder: Renal function tests depressed	VCVN5* -,400,1989
oral/human	lowest published toxic dose: 25 mg/kg	Lung, Thorax, or Respiration: Respiratory obstruction Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea	VCVN5* -,400,1989
oral/mouse	lethal dose (50 percent kill): 1000 mg/kg	Behavioral: Change in motor activity (specific assay)	VCVN5* -,399,1989
oral/mouse	lethal dose (50 percent kill): 22 gm/kg		DRFUD4 4,876,1979
oral/rabbit	lethal dose (50 percent kill): 10 gm/kg		DRFUD4 4,876,1979
oral/rabbit	lowest published lethal dose: 5 mg/kg	Blood: Other hemolysis with or without anemia	VCVN5* -,399,1989
oral/rat	lethal dose (50 percent kill): 14 gm/kg		DRFUD4 4,876,1979
oral/woman	lowest published toxic dose: 26 mg/kg/1Y- intermittent	Endocrine: Evidence of thyroid hyperfunction	PGMJAO 62,661,1986
subcutaneous/mouse	lethal dose (50 percent kill): >8650 mg/kg		NIIRDN -,1226,1990
subcutaneous/rabbit	lowest published lethal dose: 175 mg/kg		HBTXAC 5,76,1959
subcutaneous/rat	lethal dose (50 percent kill): 10500 mg/kg		NIIRDN -,1226,1990
unreported route/man	lowest published lethal dose: 29 mg/kg		85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	lowest published toxic concentration: 0.5 mg/m³/24H/8W- continuous	Olfaction: Change in sensation of smell	VCVN5* -,400,1989
inhalation/rat	lowest published toxic concentration: 3.1 mg/m³/24H/13W- continuous	Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Renal function tests depressed Endocrine: Other changes	VCVN5* -,400,1989
inhalation/rat	lowest published toxic concentration: 1.38 mg/m³/24H/13W- continuous	Behavioral: Change in motor activity (specific assay) Behavioral: Aggression	VCVN5* -,400,1989
oral/rat	lowest published toxic dose: 746 mg/kg/14W- continuous	Blood: Other changes	JTEHD6 32,89,1991
oral/woman	lowest published toxic dose: 864 mg/kg/26W- intermittent	Endocrine: Evidence of thyroid hyperfunction Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCLPH* 23(Suppl 1),103,2009
oral/woman	lowest published toxic dose: 378 µg/kg/18W- intermittent	Endocrine: Other changes	NETEEC 51,45,2015

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.01 ppm (inhal, vapor)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FOREAE 7,313,1942
TOXICOLOGY REVIEW		KOTTAM 11,1300,1975
TOXICOLOGY REVIEW		HUTOX* -,661,1996
TOXICOLOGY REVIEW		HTOPA* 1,595,2002
TOXICOLOGY REVIEW		SFDRA* 38,443,2016

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,258,1998
Mine Safety and Health Administration (MSHA) STANDARD	air-ceiling concentration 0.1 ppm (1 mg/m³)	DTLVS* 3,135,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 0.1 ppm (0.1 mg/m³), JAN1993
Occupational Exposure Limit-AUSTRALIA	ceiling concentration 0.1 ppm (1 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.1 ppm (1 mg/m³);KZW 0.1 ppm (1 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 ppm (1 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	ceiling concentration 0.1 ppm (1 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	short term exposure limit 0.1 ppm (1.1 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VLE 0.1 ppm (1 mg/m³), FEB2006
Occupational Exposure Limit-HUNGARY	time-weighted average 1 mg/m³, short term exposure limit 1 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	short term exposure limit 0.1 ppm (1 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.1 ppm (1 mg/m³), s2 sen, MAY2012
Occupational Exposure Limit-KOREA	ceiling concentration 0.1 ppm (1 mg/m³), 2006
Occupational Exposure Limit-MEXICO	peak 0.1 ppm (1 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	ceiling concentration 0.1 ppm (1 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.1 ppm (1 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average short term exposure limit 0,1 ppm (1 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 1 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 1 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	ceiling concentration 0.1 ppm (1 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 0.1 ppm (1 mg/m³), sen, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 0.1 ppm (1 mg/m³), JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-C 1 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.1 ppm (1 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.1 ppm (1 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	short term exposure limit 0.1 ppm (1.1 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	ceiling concentration 0.1 ppm (1 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	ceiling concentration 0.1 ppm (1 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	ceiling concentration 0.1 ppm (1 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	ceiling concentration 0.1 ppm (1 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IODINE-air	ceiling concentration 0.1 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 40030; Number of Industries 63; Total Number of Facilities 6179; Number of Occupations 77; Total Number of Employees Exposed 204902; Total Number of Female Employees Exposed 129889
National Occupational Hazard Survey 1974	Hazard Code 40030; Number of Industries 51; Total Number of Facilities 7490; Number of Occupations 46; Total Number of Employees Exposed 124917

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Iodine, 6005
OSHA ANALYTICAL METHOD #ID-177

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health