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Registry of Toxic Effects of Chemical Substances (RTECS)

Hydrogen peroxide, 90%

RTECS #

MX0900000

CAS #

7722-84-1

Updated

October 2017

Molecular Weight

34.02

Molecular Formula

H2O2

Synonyms

Albone
Dihydrogen dioxide
Hioxyl
Hydrogen dioxide
Hydrogen peroxide
Hydrogen peroxide (ACGIH:OSHA)
Hydroperoxide
Inhibine
Oxydol
Perhydrol
Perone
Perossido di idrogeno (Italian)
Peroxan
Peroxide
Peroxyde d'hydrogene (French)
Superoxol
T-Stuff
Wasserstoffperoxid (German)
Waterstofperoxyde (Dutch)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 1 mg severeJTPAE7 29,308,2001

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic AnalysisAscites tumor/mouse10 mmol/LMUREAV 4,385,1967
Cytogenetic Analysisembryo/mouse10 µmol/LIDZAAW 56,1,1981
Cytogenetic Analysisovary/hamster1 mmol/LCALEDQ 5,199,1978
Cytogenetic Analysislung/hamster100 µmol/LIDZAAW 56,1,1981
Cytogenetic Analysisembryo/hamster100 µmol/LIDZAAW 56,1,1981
Cytogenetic Analysisfibroblast/hamster250 mg/LESKHA5 (96),55,1978
Cytogenetic Analysisother cell types/human1.5 mg/L/4HMUREAV 578,100,2005
Cytogenetic Analysislymphocyte/human30 µmol/L/30MMUREAV 559,97,2004
Cytogenetic Analysisovary/hamster0.3 mmol/L/1HMUREAV 649,114,2008
Cytogenetic Analysislymphocyte/human10 µmol/L/2HMUREAV 669,155,2009
DNA adductembryo/hamster0.09 µmol/L/1HMUREAV 563,35,2004
DNA adductlymphocyte/human25 µmol/L/1HMUREAV 582,155,2005
DNA adductother cell types/human50 µmol/L/4HCNREA8 69,3052,2009
DNA Damagelymphocyte/human1 µmol/L/2HTOSCF2 72,283,2003
DNA Damagefibroblast/human250 µmol/L/5MMUREAV 677,46,2009
DNA Damagemammary gland/human50 µmol/L/10MFCTOD7 48,1092,2010
DNA Damageother cell types/human50 µmol/L/10MFCTOD7 48,1092,2010
DNA Damage/Saccharomyes cerevisiae10 mmol/L/20MFCTOD7 49,1361,2011
DNA Damageleukocyte/human300 µmol/L/2HMUREAV 726,146,2011
DNA Damageoral/Drosophila melanogaster50 µmol/L/24H- intermittentMUREAV 726,222,2011
DNA Damagelymphocyte/human10 µmol/L (+/-enzymatic activation step)MUREAV 743,25,2012
DNA Damagesperm/human10 µmol/L (+/-enzymatic activation step)MUREAV 743,25,2012
DNA Damageother cell types/mouse200 µmol/L/30MTIHEEC 25,5,2009
DNA Damagelymphocyte/human70 µmol/L/40MMUREAV 724,41,2011
DNA Damageother cell types/human70 µmol/L/60MMUREAV 724,41,2011
DNA Damagelymphocyte/human10 µmol/L/5MMUREAV 748,60,2012
DNA Damagelymphocyte/human0.3 mg/L/1HFCTOD7 49,763,2011
DNA Damageovary/hamster200 µmol/L/1HFCTOD7 49,385,2011
DNA Damagelymphocyte/human10 µmol/LFCTOD7 49,2947,2011
DNA Damageother cell types/human10 µmol/L/5MMUREAV 749,70,2012
DNA Damagefibroblast/hamster100 µmol/L/30MFCTOD7 50,1796,2012
DNA Damageother cell types/mouse0.25 mmol/L/5MFCTOD7 50,2275,2012
DNA DamageHeLa cell/human300 µmol/L/1HFCTOD7 50,3475,2012
DNA Damagefibroblast/mouse10 µmol/L/10MMUREAV 745-746,16,2013
DNA Damageother cell types/human1 µmol/L/12HMUTAEX 28,515,2013
DNA Damageother cell types/human80 µmol/L/4HMUTAEX 28,583,2013
DNA Damage/Schizosaccharomyces pombe1 mmol/L/30MEMMUEG 54,327,2013
DNA Damagefibroblast/hamster100 µmol/L/1HMUREAV 747,86,2012
DNA Damagelymphocyte/man25 µmol/L/5MTIVIEQ 26,369,2012
DNA Damagelymphocyte/rat5 µmol/L/2HMUREAV 761,10,2014
DNA Damagelymphocyte/rat5 µmol/L/4HMUREAV 761,10,2014
DNA Damagelymphocyte/non-mammalian species50 µmol/L/1HMUREAV 754,22,2013
DNA Damagefibroblast/hamster100 µmol/L/10MTIVIEQ 27,864,2013
DNA Damageother cell types/human50 µmol/L/24HNRTXDN 33,1086,2012
DNA Damagefibroblast/human80 µmol/L/3HTIVIEQ 28,31,2014
DNA Damageleukocyte/human25 µmol/L/15MTIVIEQ 28,451,2014
DNA Damageother cell types/human10 µmol/LMUREAV 745,6,2013
DNA Damageother cell types/human50 µmol/L/20MMUREAV 791,12,2015
DNA Damagelung/human25 µmol/L/24HTIVIEQ 26,752,2012
DNA Damageliver/mouse50 µmol/L/1HTOXID9 44,153,2005
DNA Damagefibroblast/human50 mmol/L/1HTOLED5 147,35,2004
DNA Damagelymphocyte/human100 µmol/L/3MMUREAV 587,52,2005
DNA Damageother cell types/human100 µmol/L/3MMUREAV 587,52,2005
DNA Damageembryo/salmon5 µmol/L/1HMUREAV 563,89,2004
DNA Damageother cell types/mouse200 µmol/L/1H (-enzymatic activation step)MUREAV 541,9,2003
DNA Damageovary/hamster200 µmol/L/5MMUREAV 560,41,2004
DNA Damagemammary gland/human9.8 mg/L/24H (-enzymatic activation step)MUREAV 588,47,2005
DNA Damagefibroblast/mouse500 µmol/L/1HFCTOD7 44,261,2006
DNA Damageother cell types/human200 µmol/L/60MMUREAV 577S,1,2005
DNA Damageother cell types/human2000 µmol/L/3H (-enzymatic activation step)MUTAEX 20,193,2005
DNA Damageother cell types/rat75 µmol/L/5MTOLED5 159,212,2005
DNA Damagelymphocyte/rat50 µmol/L/5MTOLED5 164,54,2006
DNA Damagetestis/rat50 µmol/L/5MTOLED5 164,54,2006
DNA Damagelung/rat50 µmol/L/5MTOLED5 164,54,2006
DNA Damageliver/rat50 µmol/L/5MTOLED5 164,54,2006
DNA Damageother cell types/woman1 mmol/L/1HTXCYAC 222,71,2006
DNA Damagelung/hamster150 µmol/L/1HMUREAV 631,44,2007
DNA Damageliver/human1 mmol/l/48HMUREAV 696,21,2010
DNA Damageliver/human0.316 mmol/l/48HMUREAV 696,21,2010
DNA Damageliver/human56 µmol/L/10MMUREAV 657,133,2008
DNA Damagelung/human0.05 mmol/L/5MTOXID9 -,221,2009
DNA Damagelymphocyte/human25 µmol/L/30M (-enzymatic activation step)FCTOD7 48,320,2010
DNA Damagelymphocyte/human5 µmol/L/10MMUREAV 652,46,2008
DNA Damagefibroblast/human20 µmol/L/15MMUREAV 701,103,2010
DNA Damagelymphocyte/human20 µmol/L/15MMUREAV 701,103,2010
DNA Damagefibroblast/hamster40 µmol/L/15MMUREAV 701,103,2010
DNA Damageliver/human40 µmol/L/15MMUREAV 701,103,2010
DNA DamageHeLa cell/human40 µmol/L/15MMUREAV 701,103,2010
DNA Damageother cell types/rat100 µmol/L/20MNRSCDN 151,518,2008
DNA Damageleukocyte/human200 µmol/L/5MMUREAV 718,56,2011
DNA Damageother cell types/mouse190 µmol/L/4HMUREAV 678,123,2009
DNA Damageother cell types/human25 µmol/L/30MTOLED5 170,57,2007
DNA Damagelymphocyte/rat50 µmol/L/10MMUREAV 564,75,2004
DNA Damagemammary gland/human100 µmol/L/5MTXAPA9 232,169,2008
DNA Damagefibroblast/human100 µmol/L/20MMUREAV 546,93,2004
DNA Damageother cell types/rat100 µmol/L/10MMUREAV 634,51,2007
DNA Damageother cell types/rat1 mmol/L/30MNRTXDN 28,886,2007
DNA Damageother cell types/rat0.1 mmol/L/6HNRTXDN 28,886,2007
DNA Damageother cell types/mouse50 µmol/LMUTAEX 20,469,2005
DNA Damagelymphocyte/human5.0 mg/L/48HMUREAV 607,160,2006
DNA Damageother cell types/hamster40 µmol/L/1HMUREAV 559,39,2004
DNA Damageovary/hamster20 µmol/LMUREAV 299,95,1993
DNA Damagelung/hamster353 µmol/LNATUAS 282,318,1979
DNA Damageother cell types/cattle25 µmol/LMUREAV 240,35,1990
DNA Damagelymphocyte/mammal (species unspecified)600 µmol/LDECRDP 8,1,1982
DNA Damagelung/human300 µmol/L/1HMUREAV 515,99,2002
DNA Damageliver/rat300 µmol/L/1HMUREAV 515,99,2002
DNA Damageother cell types/human100 µmol/L/3HMUTAEX 16,439,2001
DNA Damageother cell types/rat10 µmol/L/24HATSUDG 75,243,2001
DNA Damageother cell types/human10 µmol/L/15MMUREAV 519,151,2002
DNA Damagelung/hamster200 µmol/L/24HARTODN 75,604,2001
DNA Damagelymphocyte/human0.01 mmol/L/1HMUREAV 535,25,2003
DNA Damageother cell types/human0.01 mmol/L/1HMUREAV 535,25,2003
DNA Damageother cell types/mouse0.01 mmol/L/1HMUREAV 535,25,2003
DNA Damagelymphocyte/human0.01 mmol/L/30MTCMUD8 20,11,2000
DNA Damage/Escherichia coli0.001 µmol/plate/2HMUREAV 535,171,2003
DNA Damageother cell types/other fish0.001 mmol/L/5MMUREAV 534,165,2003
DNA Damageother cell types/non-mammalian species0.04 mmol/L/1HMUREAV 539,19,2003
DNA Damagesperm/human80 µmol/L/1HMUREAV 544,173,2003
DNA Damagefibroblast/mouse25 µmol/L/15MMUREAV 531,165,2003
DNA Damageother cell types/non-mammalian species44 µmol/L/20MMUREAV 542,15,2003
DNA Damageother cell types/rat200 µmol/LCRNGDP 20,629,1999
DNA Damageother cell types/mouse100 µmol/LJCINAO 77,1312,1986
DNA Damageother cell types/mouse1 µmol/LCRNGDP 4,1507,1983
DNA Damagelymphocyte/mouse2 mmol/LMUREAV 203,155,1988
DNA Damagefibroblast/human28 µmol/LBBACAQ 781,56,1984
DNA Damageleukocyte/human20 µmol/LMUREAV 265,255,1992
DNA Damage/Bacillus subtilis50 mmol/LBBACAQ 155,476,1968
DNA Damage/Other microorganisms1 mmol/LMUREAV 368,235,1996
DNA Damage/Neurospora crassa50 µmol/LMUREAV 405,29,1998
DNA inhibitionother cell types/human1200 µmol/LCNREA8 45,2522,1985
DNA inhibitionother cell types/mouse40 µmol/LJCINAO 77,1312,1986
DNA inhibitionfibroblast/human1 mg/LCRNGDP 4,1317,1983
DNA repair/Salmonella typhimurium2 mmol/L/60MMUREAV 502,11,2002
DNA repairother cell types/human10 mmol/L/10MMUREAV 537,1,2003
DNA repairfibroblast/human20 µmol/L/1HMUREAV 513,159,2002
DNA repair/Escherichia coli14630 µg/well/16HCBINA8 15,219,1976
DNA repairother cell types/human10 µmol/L/20MMUREAV 577S,1,2005
DNA repairother cell types/other fish10 µmol/L/10MMUREAV 753,107,2013
DNA repairother cell types/human1 µmol/L/12HMUTAEX 28,515,2013
DNA repairfibroblast/mouse5 µmol/L/6DMUREAV 745-746,16,2013
DNA repairlymphocyte/human100 µmol/LMUREAV 724,46,2011
gene conversion and mitotic recombinationother cell types/Drosophila melanogaster120 mmol/LFCTOD7 50,1384,2012
gene conversion and mitotic recombination/Saccharomyes cerevisiae5 pphAGACBH 4,286,1974
micronucleus testother cell types/human10 µmol/LMUREAV 577S,1,2005
micronucleus testlung/hamster150 µmol/L/1HMUREAV 631,44,2007
micronucleus testovary/hamster500 µmol/L/24H (-enzymatic activation step)MUREAV 630,1,2007
micronucleus testembryo/hamster5 mg/L/4H (-enzymatic activation step)MUREAV 561,153,2004
micronucleus testlymphocyte/human3.4 mg/L/24HEMMUEG 43,45,2004
micronucleus testlymphocyte/human30 µmol/L/30MMUREAV 559,97,2004
micronucleus testother cell types/mouse20 µmol/L/4HMUREAV 678,123,2009
micronucleus testlung/human25 µmol/L/24HTIVIEQ 26,752,2012
micronucleus testother cell types/human40 µmol/LMUTAEX 28,583,2013
micronucleus testlymphocyte/pig10 µmol/L/72HMUREAV 653,124,2008
micronucleus testother cell types/human40 µmol/L/4HMUTAEX 28,583,2013
morphological transformliver/rat100 µmol/L/7WMOCAE8 30,209,2001
morphological transformembryo/mouse20 µmol/LCRNGDP 10,1055,1989
morphological transformembryo/hamster2500 µg/LMUREAV 356,85,1996
mutation in mammalian somatic cellslung/hamster10 µmol/LCRNGDP 10,1055,1989
mutation in mammalian somatic cellskidney/monkey7 mmol/LCRNGDP 11,283,1990
mutation in mammalian somatic cellslymphocyte/mouse18600 nmol/LMUTAEX 3,193,1988
mutation in microorganisms/Schizosaccharomyces pombe2820 mmol/L (-enzymatic activation step)ADWMAX -,193,1962
mutation in microorganisms/Bacillus subtilis5 ppm (-enzymatic activation step)MUREAV 95,191,1982
mutation in microorganisms/Salmonella typhimurium6 µg/plate (-enzymatic activation step)ABCHA6 44,1989,1980
mutation in microorganisms/Escherichia coli5 pph (-enzymatic activation step)AGACBH 4,286,1974
mutation in microorganisms/Saccharomyes cerevisiae10 mg/L (-enzymatic activation step)MUREAV 33,147,1975
mutation in microorganisms/Neurospora crassa210 mmol/L/30M (-enzymatic activation step)PNASA6 35,581,1949
mutation in microorganisms/Haemophilus influenzae800 µmol/L (-enzymatic activation step)MUREAV 30,9,1975
mutation in microorganisms/Other microorganisms6 ppm/1H-continuous (-enzymatic activation step)JOBAAY 54,767,1947
mutation in microorganisms/Other microorganisms6 ppm (-enzymatic activation step)POASAD 34,114,1953
mutation in microorganisms/Bacillus subtilis5 pph/15MMUREAV 503,77,2002
mutation in microorganisms/Salmonella typhimurium1.87 mg/plate/30MMUREAV 535,171,2003
mutation in microorganisms/Salmonella typhimurium25 µg/plate/48H (+/-enzymatic activation step)MUREAV 539,29,2003
mutation in microorganisms/Escherichia coli100 µg/plate/48H (+/-enzymatic activation step)MUREAV 539,29,2003
mutation in microorganisms/Salmonella typhimurium34000 ng/plate/72HMUREAV 542,49,2003
mutation in microorganisms/Salmonella typhimurium500 µg/plate/66H (-enzymatic activation step)EMMUEG 40,63,2002
mutation in microorganisms/Salmonella typhimurium51 µg/plate/72H (-enzymatic activation step)MUTAEX 15,495,2000
mutation in microorganisms/Salmonella typhimurium20 µL/plate/30MDCTODJ 27,157,2004
mutation in microorganisms/Salmonella typhimurium2.6 mmol/L/2HMUREAV 578,225,2005
mutation in microorganisms/Saccharomyes cerevisiae68.5 mg/L/16HMUTAEX 20,105,2004
mutation in microorganisms/Salmonella typhimurium3 mg/L/2H (-enzymatic activation step)MUREAV 578,210,2005
mutation in microorganisms/Saccharomyes cerevisiae316 µmol/L/6HMUREAV 676,113,2009
mutation in microorganisms/Escherichia coli1 µg/L/2H (-enzymatic activation step)FCTOD7 48,320,2010
mutation in microorganisms/Salmonella typhimurium1.87 mg/plate/48HMUREAV 535,171,2003
mutation in microorganisms/Escherichia coli1.1 mmol/L/2HMUREAV 535,171,2003
mutation in microorganisms/Saccharomyes cerevisiae20 µmol/L/10MMUREAV 673,53,2009
mutation in microorganisms/Saccharomyes cerevisiae2 µmol/lMUREAV 547,123,2004
mutation in microorganisms/Salmonella typhimurium100 µg/plate/48H (-enzymatic activation step)FCTOD7 50,3360,2012
mutation in microorganisms/Escherichia coli1.2 mmol/L/30MMUREAV 714,11,2011
mutation in microorganisms/Saccharomyes cerevisiae4 mmol/L/1HEMMUEG 48,728,2007
mutation in microorganisms/Salmonella typhimurium0.1 µmol/L/48HEMMUEG 50,451,2009
mutation in microorganisms/Salmonella typhimurium4 mmol/LMUTAEX 22,293,2007
other mutation test systemsother cell types/human0.5 mmol/L/6HMUREAV 648,15,2008
other mutation test systems/Escherichia coli100 µmol/LMUREAV 203,81,1988
other mutation test systems/Salmonella typhimurium45 mg/LMUREAV 192,239,1987
other mutation test systems/Bacillus subtilis100 µmol/LMUREAV 4,517,1967
other mutation test systemsother cell types/human1200 µmol/LCNREA8 45,2522,1985
phage inhibition capacity/Escherichia coli500 ng/wellMUREAV 260,349,1991
sister chromatid exchangelung/hamster40 µmol/LMUREAV 174,21,1986
sister chromatid exchangeovary/hamster80 µmol/LMUREAV 224,269,1989
sister chromatid exchange/Saccharomyes cerevisiae0.04 pphMUREAV 547,123,2004
sister chromatid exchangeovary/hamster0.075 mmol/L/1HMUREAV 649,114,2008
specific locus testAscites tumor/mouse5 mg/L/4HEMMUEG 42,19,2003
specific locus testother cell types/mouse28 µmol/L/4HMUREAV 678,123,2009
specific locus testovary/hamster400 µmol/L/20MMUREAV 602,14,2006
specific locus test/Escherichia coli50 µmol/L/30MMUREAV 628,123,2007
specific locus test/Escherichia coli1 µmol/L/4HMUREAV 560,27,2004
specific locus testkidney/mouse65 µmol/LMUREAV 503,69,2002
specific locus test/Escherichia coli2.5 mmol/L/10MMUREAV 508,107,2002
specific locus testoral/Drosophila melanogaster0.18 mole/L/4D-continuousMUREAV 703,137,2010
specific locus testother cell types/human144000000 units/LMUREAV 726,151,2011
specific locus testembryo/Drosophila melanogaster0.12 mole/L/10DMUREAV 772,25,2014
Unscheduled DNA Synthesisfibroblast/human1 mmol/LCALEDQ 5,199,1978
Unscheduled DNA Synthesislung/human600 µg/LENMUDM 5,177,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 144 gm/kg/26W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
GANNA2 75,17,1984
oral/mouse toxic dose: 168 gm/kg/30W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
GANNA2 75,17,1984
skin/mouse lowest published toxic dose: 4032 mg/kg/18W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens
ARTODN 78,139,2004

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: 100 µmol/L/10MIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,864,2013
In Vitro/Hamster, ovary Inhibitor Concentration Low: 250 µmol/LIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 50,2729,2012
In Vitro/Hamster, ovary Inhibitor Concentration Low: 250 µmol/LIn Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
FCTOD7 50,2729,2012
In Vitro/Human, blood (whole or unspecified cells) Inhibitor Concentration Low: 400 µmol/LIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TXCYAC 278,242,2010
In Vitro/Human, colon tumor Inhibitor Concentration Low: 1 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Other assays
TXCYAC 290,230,2011
In Vitro/Human, colon tumor Inhibitor Concentration Low: 6 µmol/L/24HIn Vitro Toxicity Studies: Apoptosis in vitroTXAPA9 246,116,2010
In Vitro/Human, colon tumor Inhibitor Concentration Low: 500 µmol/L/24HIn Vitro Toxicity Studies: Other assaysFTRPAE 109,230,2016
In Vitro/Human, colon tumor Inhibitor Concentration (50 percent kill): 122 µmol/L/3HIn Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.TIVIEQ 26,603,2012
In Vitro/Human, colon tumor Inhibitor Concentration (50 percent kill): 120 µmol/L/3HIn Vitro Toxicity Studies: Cell countingTIVIEQ 26,603,2012
In Vitro/Human, embryonic cells Inhibitor Concentration Low: 100 µmol/LIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,351,2012
In Vitro/Human, endothelium Inhibitor Concentration Low: 100 µmol/LIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 50,3133,2012
In Vitro/Human, endothelium Inhibitor Concentration Low: 100 µmol/LIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
FCTOD7 50,3133,2012
In Vitro/Human, endothelium Inhibitor Concentration Low: 200 µmol/LIn Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro
FCTOD7 50,3133,2012
In Vitro/Human, endothelium Inhibitor Concentration Low: 200 µmol/LIn Vitro Toxicity Studies: Other assaysTIVIEQ 28,538,2014
In Vitro/Human, endothelium Inhibitor Concentration Low: 0.4 mmol/L/1HIn Vitro Toxicity Studies: Other assaysTXCYAC 305,10,2013
In Vitro/Human, endothelium Inhibitor Concentration Low: 500 µmol/L/4HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
TOLED5 232,149,2015
In Vitro/Human, endothelium Inhibitor Concentration Low: 300 µmol/L/4HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
JOETD7 143,100,2012
In Vitro/Human, endothelium Inhibitor Concentration Low: 100 µmol/L/30MIn Vitro Toxicity Studies: Other assaysJOETD7 143,664,2012
In Vitro/Human, endothelium Inhibitor Concentration Low: 400 µmol/L/4HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 154,428,2014
In Vitro/Human, endothelium Inhibitor Concentration Low: 200 µmol/L/4HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.JOETD7 154,428,2014
In Vitro/Human, erythrocytes Inhibitor Concentration Low: 3.3 mmol/L/2.5HIn Vitro Toxicity Studies: Hemolysis in vitroFCTOD7 50,141,2012
In Vitro/Human, erythrocytes Inhibitor Concentration Low: 100 µmol/L/4HIn Vitro Toxicity Studies: Hemolysis in vitro

In Vitro Toxicity Studies: Other assays
FCTOD7 49,2292,2011
In Vitro/Human, kidney Inhibitor Concentration Low: 3 pphIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,206,2012
In Vitro/Human, kidney Inhibitor Concentration Low: 50 µmol/L/1HIn Vitro Toxicity Studies: Other assaysTXCYAC 290,271,2011
In Vitro/Human, kidney Inhibitor Concentration Low: 100 µmol/L/10MIn Vitro Toxicity Studies: Other assaysTXCYAC 290,271,2011
In Vitro/Human, leukemia cells Inhibitor Concentration (50 percent kill): 0.55 mmol/L/72HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TXAPA9 258,351,2012
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 80 µmol/L/72HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TXAPA9 258,351,2012
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 80 µmol/L/6HIn Vitro Toxicity Studies: Other assaysTXAPA9 258,351,2012
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 50 µmol/L/24HIn Vitro Toxicity Studies: Other assaysJOETD7 153,207,2014
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 50 µmol/L/15MIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,1161,2012
In Vitro/Human, liver tumor Inhibitor Concentration Low: 0.3 pph/30MIn Vitro Toxicity Studies: Other assaysTIVIEQ 25,1343,2011
In Vitro/Human, liver tumor Inhibitor Concentration Low: 0.9 mmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
TXAPA9 250,130,2011
In Vitro/Human, liver tumor Inhibitor Concentration Low: 0.8 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 250,130,2011
In Vitro/Human, liver tumor Inhibitor Concentration Low: 0.9 mmol/L/30MIn Vitro Toxicity Studies: Other assaysTXAPA9 250,130,2011
In Vitro/Human, liver tumor Inhibitor Concentration Low: 40 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTOLED5 203,219,2011
In Vitro/Human, liver tumor Inhibitor Concentration Low: 2 mmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TXCYAC 272,32,2010
In Vitro/Human, liver tumor Inhibitor Concentration Low: 100 µmol/L/2HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
JOETD7 149,737,2013
In Vitro/Human, lung Inhibitor Concentration Low: 50 µmol/L/6HIn Vitro Toxicity Studies: Other assaysTXCYAC 287,105,2011
In Vitro/Human, lung Inhibitor Concentration Low: 200 µmol/L/12HBiochemical: Metabolism (intermediary): Effect on mitochondrial functionFCTOD7 50,2417,2012
In Vitro/Human, lung Inhibitor Concentration Low: 100 µmol/LIn Vitro Toxicity Studies: Other assaysTIVIEQ 25,1353,2011
In Vitro/Human, lung Inhibitor Concentration Low: 100 µmol/L/2HIn Vitro Toxicity Studies: Other assaysTXAPA9 258,166,2012
In Vitro/Human, lung tumor Inhibitor Concentration Low: 100 µmol/L/48HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 27,1762,2013
In Vitro/Human, lung tumor Inhibitor Concentration Low: 100 µmol/L/15MIn Vitro Toxicity Studies: Other assaysTXCYAC 305,109,2013
In Vitro/Human, lymphocyte Inhibitor Concentration Low: 100 µmol/L/10MIn Vitro Toxicity Studies: Other assaysFCTOD7 49,2292,2011
In Vitro/Human, lymphocyte Inhibitor Concentration Low: 10 µmol/L/10MIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay

In Vitro Toxicity Studies: Apoptosis in vitro
FCTOD7 49,2947,2011
In Vitro/Human, melanoma Inhibitor Concentration Low: 500 µmol/L/120MIn Vitro Toxicity Studies: Other assaysFCTOD7 50,823,2012
In Vitro/Human, melanoma Inhibitor Concentration Low: 30 pph/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 50,1001,2012
In Vitro/Human, melanoma Inhibitor Concentration Low: 100 µmol/L/4HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
NETOX* 32,518,2011
In Vitro/Human, melanoma Inhibitor Concentration Low: 1 mmol/L/3HIn Vitro Toxicity Studies: Other assaysFCTOD7 50,1454,2012
In Vitro/Human, melanoma Inhibitor Concentration Low: 100 µmol/LIn Vitro Toxicity Studies: Other assaysFCTOD7 50,1589,2012
In Vitro/Human, melanoma Inhibitor Concentration Low: 50 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.FCTOD7 50,1841,2012
In Vitro/Human, monocyte Inhibitor Concentration Low: 0.5 mmol/L/15MIn Vitro Toxicity Studies: Other assaysTXAPA9 246,66,2010
In Vitro/Human, monocyte Inhibitor Concentration Low: 0.5 mmol/L/30MBiochemical: Metabolism (intermediary): Effect on mitochondrial functionTXAPA9 246,66,2010
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 300 µmol/L/2HIn Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro
TIVIEQ 27,1780,2013
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 300 µmol/L/30MIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1780,2013
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 1 mmol/L/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
TIVIEQ 26,304,2012
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 1 mmol/L/16HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro

In Vitro Toxicity Studies: Other assays
FCTOD7 50,492,2012
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 25 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 80,41,2015
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Apoptosis in vitro
FCTOD7 80,41,2015
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 400 µmol/L/24HIn Vitro Toxicity Studies: Apoptosis in vitroFCTOD7 80,41,2015
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 400 µmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro
JOETD7 142,337,2012
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 400 µmol/L/1HIn Vitro Toxicity Studies: Other assaysJOETD7 142,337,2012
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 100 µmol/LIn Vitro Toxicity Studies: Other assaysFCTOD7 49,2780,2011
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
TOLED5 228,179,2014
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 500 µmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
JOETD7 136,297,2011
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 50 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.NRTXDN 33,1086,2012
In Vitro/Human, skin Inhibitor Concentration Low: 10 mmol/L/18HIn Vitro Toxicity Studies: Other assaysTXCYAC 271,83,2010
In Vitro/Human, skin Inhibitor Concentration (75 percent kill): 3.85 mmol/L/3HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 28,120,2014
In Vitro/Human, skin Inhibitor Concentration Low: 100 µmol/L/20MIn Vitro Toxicity Studies: Other assaysJOETD7 148,537,2013
In Vitro/Human, skin Inhibitor Concentration (20 percent kill): 34.0 mg/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,314,2013
In Vitro/Human, skin Inhibitor Concentration Low: 5 mmol/L/24HIn Vitro Toxicity Studies: Apoptosis in vitro

In Vitro Toxicity Studies: Other assays
TXAPA9 255,242,2011
In Vitro/Human, skin Inhibitor Concentration Low: 5 mmol/L/24HIn Vitro Toxicity Studies: Apoptosis in vitroTXAPA9 255,242,2011
In Vitro/Human, tooth Inhibitor Concentration Low: 1 mmol/L/12HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
TIVIEQ 27,874,2013
In Vitro/jahInhibitor Concentration Low: 40 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTOLED5 203,219,2011
In Vitro/jahInhibitor Concentration Low: 1 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.NRTXDN 33,1368,2012
In Vitro/jahInhibitor Concentration Low: 1 mmol/L/30MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.
PYTOEY 22,847,215
In Vitro/jahInhibitor Concentration Low: 1 mmol/L/150MIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)PYTOEY 22,847,215
In Vitro/jmaInhibitor Concentration Low: 100 µmol/L/1HIn Vitro Toxicity Studies: Other assaysTXAPA9 257,1,2011
In Vitro/jrdInhibitor Concentration Low: 0.4 mmol/L/1HIn Vitro Toxicity Studies: Other assaysTXCYAC 305,10,2013
In Vitro/jtgInhibitor Concentration Low: 6 pphIn Vitro Toxicity Studies: Other assays

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
JOETD7 153,119,2014
In Vitro/jtiInhibitor Concentration Low: 50 µmol/L/12HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 26,429,2012
In Vitro/jtiInhibitor Concentration Low: 100 µmol/L/12HIn Vitro Toxicity Studies: Apoptosis in vitroTIVIEQ 26,429,2012
In Vitro/jtiInhibitor Concentration Low: 1 mmol/L/30MBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PeptidasesTXAPA9 244,315,2010
In Vitro/jvxInhibitor Concentration Low: 300 µmol/L/1HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1877,2013
In Vitro/maxInhibitor Concentration Low: 1 mmol/LIn Vitro Toxicity Studies: Other assaysTXCYAC 290,342,2011
In Vitro/mgaInhibitor Concentration Low: 0.68 mg/L/5DIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1503,2013
In Vitro/Mouse, embryo Inhibitor Concentration Low: 5 µmol/L/1HReproductive: Other effects to embryo or fetusJOETD7 154,600,2014
In Vitro/Mouse, fibroblast Inhibitor Concentration (75 percent kill): 2.2 mmol/L/3HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 28,120,2014
In Vitro/Mouse, fibroblast Inhibitor Concentration Low: 0.25 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 150,223,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 0.26 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.PYTOEY 19,1178,2012
In Vitro/Mouse, liver Inhibitor Concentration Low: 1 mmol/L/6HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro

In Vitro Toxicity Studies: Other assays
JOETD7 155,132,2014
In Vitro/Mouse, macrophage Inhibitor Concentration Low: 100 µmol/L/3HIn Vitro Toxicity Studies: Other assaysJOETD7 156,61,2014
In Vitro/Mouse, macrophage Inhibitor Concentration Low: 500 µmol/L/10MIn Vitro Toxicity Studies: Other assaysTXAPA9 255,32,2011
In Vitro/Mouse, macrophage Inhibitor Concentration Low: 400 µmol/L/2HIn Vitro Toxicity Studies: Other assaysTXAPA9 246,91,2010
In Vitro/Mouse, neuroblastom Inhibitor Concentration (50 percent kill): 10 µmol/L/24HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTXAPA9 258,208,2012
In Vitro/Mouse, neuroblastom Inhibitor Concentration Low: 50 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 148,980,2013
In Vitro/Mouse, neuroblastom Inhibitor Concentration Low: 2 mmol/L/10HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 83,223,2012
In Vitro/Mouse, neurons Inhibitor Concentration (50 percent kill): 1.2 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 256,369,2011
In Vitro/mtgInhibitor Concentration Low: 1 µmol/L/2HIn Vitro Toxicity Studies: Apoptosis in vitroTOLED5 225,86,2014
In Vitro/mvbInhibitor Concentration Low: 1 mmol/L/3HIn Vitro Toxicity Studies: Other assays

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TIVIEQ 25,2025,2011
In Vitro/mzxInhibitor Concentration (50 percent kill): 3.7 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 256,369,2011
In Vitro/mzxInhibitor Concentration Low: 5 µmol/L/1HIn Vitro Toxicity Studies: Other assaysTXAPA9 256,369,2011
In Vitro/paaInhibitor Concentration Low: 20 µmol/L/10MBrain and Coverings: Recordings from specific areas of CNS

In Vitro Toxicity Studies: Other assays
JOETD7 134,147,2011
In Vitro/paaInhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTXCYAC 305,71,2013
In Vitro/pahInhibitor Concentration Low: 20 µmol/L/72HIn Vitro Toxicity Studies: Cell protein synthesisFCTOD7 67,212,2014
In Vitro/paxInhibitor Concentration Low: 25 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 80,41,2015
In Vitro/pdaInhibitor Concentration Low: 300 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 49,2131,2011
In Vitro/pdaInhibitor Concentration Low: 1 mmol/LIn Vitro Toxicity Studies: Other assaysFCTOD7 49,2131,2011
In Vitro/praInhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TOLED5 205,173,2011
In Vitro/pzxInhibitor Concentration Low: 10 mmol/L/2HNutritional and Gross Metabolic: Changes in: Other metalsTXCYAC 276,27,2010
In Vitro/pzxInhibitor Concentration Low: 10 µmol/L/2HIn Vitro Toxicity Studies: Other assaysTXCYAC 276,27,2010
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 200 µmol/L/4HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 134,275,2011
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 0.1 mmol/L/30MIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
JOETD7 147,645,2013
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 50 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.NRTXDN 33,138,2012
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 2 µmol/L/1HEndocrine: Other changesTXAPA9 258,216,2012
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 150 µmol/L/24HIn Vitro Toxicity Studies: Other assaysPYTOEY 20,939,2013
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 150 µmol/L/24HIn Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.

In Vitro Toxicity Studies: Apoptosis in vitro

In Vitro Toxicity Studies: Other assays
TIVIEQ 26,907,2012
In Vitro/Rat, fibroblast Inhibitor Concentration Low: 10 µmol/L/30MIn Vitro Toxicity Studies: Other assaysJOETD7 145,152,2013
In Vitro/Rat, fibroblast Inhibitor Concentration Low: 100 µmol/L/30MIn Vitro Toxicity Studies: Other assays

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
JOETD7 145,152,2013
In Vitro/Rat, fibroblast Inhibitor Concentration Low: 1 µmol/L/24HBiochemical: Metabolism (intermediary): Other proteinsJOETD7 145,152,2013
In Vitro/Rat, fibroblast Inhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.

Biochemical: Metabolism (intermediary): Other proteins
JOETD7 145,152,2013
In Vitro/Rat, glioma Inhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisFCTOD7 49,2398,2011
In Vitro/Rat, glioma Inhibitor Concentration (50 percent kill): 143 µmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisFCTOD7 49,2398,2011
In Vitro/Rat, glioma Inhibitor Concentration (50 percent kill): 686 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 49,2398,2011
In Vitro/Rat, liver Inhibitor Concentration Low: 0.01 mmol/LIn Vitro Toxicity Studies: Other assaysTXCYAC 278,356,2010
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 0.214 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 18,79,2004
In Vitro/Rat, myocard Inhibitor Concentration (50 percent kill): 400 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 303,54,2013
In Vitro/Rat, myocard Inhibitor Concentration Low: 400 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTXCYAC 303,54,2013
In Vitro/Rat, myocard Inhibitor Concentration Low: 150 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 215,219,2012
In Vitro/Rat, myocard Inhibitor Concentration Low: 400 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro

In Vitro Toxicity Studies: Other assays
JOETD7 149,720,2013
In Vitro/Rat, myocard Inhibitor Concentration Low: 0.1 mmol/L/3HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro
FTRPAE 88,44,2013
In Vitro/Rat, myocard Inhibitor Concentration Low: 100 µmol/L/4HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayFTRPAE 90,185,2013
In Vitro/Rat, myocard Inhibitor Concentration Low: 200 µmol/L/4HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
TIVIEQ 27,1686,2013
In Vitro/Rat, myocard Inhibitor Concentration Low: 200 µmol/L/1HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1686,2013
In Vitro/Rat, myocard Inhibitor Concentration Low: 600 µmol/L/6HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro
JOETD7 153,552,2014
In Vitro/Rat, myocard Inhibitor Concentration Low: 600 µmol/L/30MIn Vitro Toxicity Studies: Other assaysJOETD7 153,552,2014
In Vitro/Rat, neurons Inhibitor Concentration Low: 10 mmol/L/0.5MNutritional and Gross Metabolic: Changes in: Ca

In Vitro Toxicity Studies: Other assays
JOETD7 134,147,2011
In Vitro/Rat, neurons Inhibitor Concentration Low: 100 µmol/L/3HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TXAPA9 254,65,2011
In Vitro/Rat, neurons Inhibitor Concentration Low: 25 µmol/L/24HIn Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.FCTOD7 49,2862,2011
In Vitro/Rat, neurons Inhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.

In Vitro Toxicity Studies: Apoptosis in vitro

In Vitro Toxicity Studies: Other assays
FCTOD7 49,2862,2011
In Vitro/Rat, neurons Inhibitor Concentration Low: 120 µmol/L/10HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro
JOETD7 134,147,2011
In Vitro/Rat, neurons Inhibitor Concentration Low: 50 µmol/L/4HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro
NRTXDN 36,24,2013
In Vitro/Rat, testis Inhibitor Concentration Low: 10 µmol/L/3HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,950,2012
In Vitro/Rat, testis Inhibitor Concentration Low: 1 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,950,2012
inhalation/human lowest published toxic concentration: 2.2 ppm/2HOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes
TOLED5 212,222,2012
inhalation/human lowest published toxic concentration: 20 mg/m3Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Tetany

Cardiac: Arrythmias (indlucing changes in conduction)
VCVN1* -,18,1998
inhalation/human lowest published toxic concentration: 10 mg/m3Skin: After topical application: Primary irritationVCVN1* -,18,1998
inhalation/mammal (species unspecified) lowest published toxic concentration: 60 mg/m3/4HSkin: After topical application: Primary irritationVCVN1* -,17,1998
inhalation/mouse Lowest published lethal concentration: 227 ppmAEHLAU 4,327,1962
inhalation/rat lethal concentration (50 percent kill): 2 gm/m3/4HLung, Thorax, or Respiration: Pulmonary emboliGTPZAB 21(10),22,1977
inhalation/rat lethal concentration (50 percent kill): 2000 mg/m3VCVN1* -,17,1998
intraperitoneal/mouse lethal dose (50 percent kill): 880 mg/kgVCVN1* -,17,1998
intravenous/Dog lowest published toxic dose: 0.003 mg/kgBehavioral: Excitement

Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,17,1998
intravenous/horse, donkey lowest published toxic dose: 40 µg/kgCardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
VCVN1* -,17,1998
intravenous/rabbit lowest published lethal dose: 0.004 mg/kgBehavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,17,1998
intravenous/rabbit lethal dose (50 percent kill): 15 gm/kgBehavioral: Convulsions or effect on seizure thresholdMRLR** #75,1951
oral/mouse lethal dose (50 percent kill): 2000 mg/kgVCVN1* -,17,1998
oral/rat lethal dose (50 percent kill): 376 mg/kgGastrointestinal: Peritonitis

Blood: Pigmented or nucleated red blood cells

Blood: Changes in leukocyte (WBC) count
STGNBT -,39,1999
oral/rat lethal dose (50 percent kill): 4050 mg/kgVCVN1* -,17,1998
skin/mouse lethal dose (50 percent kill): 1072 mg/kgVCVN1* -,17,1998
skin/pig lowest published lethal dose: 2 gm/kgBehavioral: Convulsions or effect on seizure thresholdMRLR** #75,1951
skin/rabbit lowest published lethal dose: 500 mg/kgBehavioral: Convulsions or effect on seizure thresholdMRLR** #75,1951
skin/rat lethal dose (50 percent kill): 4060 mg/kgLung, Thorax, or Respiration: Pulmonary emboliGTPZAB 21(10),22,1977
subcutaneous/mouse lethal dose (50 percent kill): 1072 mg/kgGISAAA 48(6),28,1983
subcutaneous/rat lethal dose (50 percent kill): 620 mg/kgVCVN1* -,17,1998
Tank with water/other fish lowest published toxic concentration: 200 µmol/L/2HMusculoskeletal: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other
FCTOD7 53,205,2013

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 7 ppm/6H/26W- intermittentSkin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Hair
AMIHBC 10,319,1954
inhalation/mouse lowest published toxic concentration: 57 ppm/6H/6W- intermittentSkin: After systemic exposure: Dermatitis, irritative

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 10,319,1954
inhalation/rat lowest published toxic concentration: 67 ppm/6H/6W- intermittentSkin: After systemic exposure: Dermatitis, irritative

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 10,319,1954
inhalation/rat lowest published toxic concentration: 10 mg/m3/5H/17W- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GTPZAB 21(10),22,1977
inhalation/rat lowest published toxic concentration: 10 mg/m3/5H/8W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesVCVN1* -,18,1998
inhalation/rat lowest published toxic concentration: 10 mg/m3/5H/17W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
VCVN1* -,18,1998
intraperitoneal/non-mammalian species lowest published toxic dose: 12 mg/kg/6D- intermittentLiver: Other changesTOXID9 66,67,2002
intraperitoneal/rat lowest published toxic dose: 1190.7 mg/kg/10W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 50,1860,2012
oral/rabbit lowest published toxic dose: 8.75 mg/kg/25W- continuousEndocrine: Effect on menstrual cycle

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN1* -,19,1988
oral/rat lowest published toxic dose: 8.75 mg/kg/25W- continuousEndocrine: Effect on menstrual cycle

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN1* -,19,1988
oral/rat lowest published toxic dose: 1400 mg/kg/14D- intermittentCardiac: Other changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 49,898,2011

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 36,285,1985
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,671,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 36,285,1985
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 71,671,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,671,1999
TOXICOLOGY REVIEW32RWA4 1,239,1976
TOXICOLOGY REVIEWMUREAV 566,99,2004
TOXICOLOGY REVIEWMUREAV 544,179,2003
TOXICOLOGY REVIEWTXAPA9 197,144,2004
TOXICOLOGY REVIEWFCTOD7 44,301,2006
TOXICOLOGY REVIEWMUTAEX 19,251,2004
TOXICOLOGY REVIEWMUREAV 616,11,2007
TOXICOLOGY REVIEWENTOX* -,543,2005
TOXICOLOGY REVIEWMUREAV 635,90,2007
TOXICOLOGY REVIEWMUTAEX 19,3,2004
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 533,65,2003
TOXICOLOGY REVIEWMUREAV 533,133,2003
TOXICOLOGY REVIEWMUREAV 533,183,2003
TOXICOLOGY REVIEWMUTAEX 19,169,2004
TOXICOLOGY REVIEWMUREAV 658,154,2008
TOXICOLOGY REVIEWMUREAV 659,15,2008
TOXICOLOGY REVIEWREPTED 25,291,2007
TOXICOLOGY REVIEWMUREAV 657,84,2008
TOXICOLOGY REVIEWHUTOX* -,683,1996
TOXICOLOGY REVIEWMUREAV 672,1,2009
TOXICOLOGY REVIEWMUREAV 543,191,2003
TOXICOLOGY REVIEWMUREAV 681,3,2009
TOXICOLOGY REVIEWBJMRDK 41,545,2008
TOXICOLOGY REVIEWMUREAV 681,24,2009
TOXICOLOGY REVIEWMUREAV 674,3,2009
TOXICOLOGY REVIEWMUREAV 674,36,2009
TOXICOLOGY REVIEWMUREAV 674,31,2009
TOXICOLOGY REVIEWMUREAV 681,44,2009
TOXICOLOGY REVIEWMUREAV 681,51,2009
TOXICOLOGY REVIEWMUREAV 674,62,2009
TOXICOLOGY REVIEWMUREAV 674,73,2009
TOXICOLOGY REVIEWMUREAV 674,137,2009
TOXICOLOGY REVIEWMUREAV 674,85,2009
TOXICOLOGY REVIEWMUREAV 681,33,2009
TOXICOLOGY REVIEWMUREAV 681,68,2009
TOXICOLOGY REVIEWMUTAEX 17,529,2002
TOXICOLOGY REVIEWMUTAEX 17,495,2002
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWMUREAV 667,98,2009
TOXICOLOGY REVIEWMUREAV 682,39,2009
TOXICOLOGY REVIEWMUTAEX 22,161,2007
TOXICOLOGY REVIEWMUTAEX 21,219,2006
TOXICOLOGY REVIEWMUTAEX 21,225,2006
TOXICOLOGY REVIEWMUREAV 579,6,2005
TOXICOLOGY REVIEWMUREAV 669,8,2009
TOXICOLOGY REVIEWMUREAV 682,94,2009
TOXICOLOGY REVIEWMUTAEX 23,153,2008
TOXICOLOGY REVIEWMUREAV 704,152,2010
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWTXAPA9 243,239,2010
TOXICOLOGY REVIEWMUREAV 690,3,2010
TOXICOLOGY REVIEWMUREAV 705,107,2010
TOXICOLOGY REVIEWMUTAEX 24,383,2009
TOXICOLOGY REVIEWMUTAEX 23,191,2008
TOXICOLOGY REVIEWMUTAEX 26,101,2011
TOXICOLOGY REVIEWMUTAEX 26,231,2011
TOXICOLOGY REVIEWMUTAEX 26,69,2011
TOXICOLOGY REVIEWMUREAV 685,3,2010
TOXICOLOGY REVIEWMUREAV 727,1,2011
TOXICOLOGY REVIEWMUTAEX 26,193,2011
TOXICOLOGY REVIEWMUTAEX 26,51,2011
TOXICOLOGY REVIEWMUTAEX 26,199,2011
TOXICOLOGY REVIEWMUREAV 711,13,2011
TOXICOLOGY REVIEWMUREAV 711,158,2011
TOXICOLOGY REVIEWMUREAV 728,47,2011
TOXICOLOGY REVIEWMUREAV 717,54,2011
TOXICOLOGY REVIEWMUREAV 750,60,2012
TOXICOLOGY REVIEWMUREAV 26,253,2011
TOXICOLOGY REVIEWMUREAV 728,35,2011
TOXICOLOGY REVIEWMUREAV 728,12,2011
TOXICOLOGY REVIEWMUREAV 750,107,2012
TOXICOLOGY REVIEWREPTED 33,188,2012
TOXICOLOGY REVIEWMUREAV 736,122,2012
TOXICOLOGY REVIEWMUREAV 751,15,2012
TOXICOLOGY REVIEWMUREAV 751,77,2012
TOXICOLOGY REVIEWMUREAV 751,247,2012
TOXICOLOGY REVIEWMUREAV 751,158,2012
TOXICOLOGY REVIEWREPTED 35,165,2013
TOXICOLOGY REVIEWMUREAV 752,25,2013
TOXICOLOGY REVIEWMUREAV 733,4,2012
TOXICOLOGY REVIEWMUREAV 752,61,2013
TOXICOLOGY REVIEWMUTAEX 25,101,2010
TOXICOLOGY REVIEWMUREAV 733,39,2012
TOXICOLOGY REVIEWMUREAV 752,99,2013
TOXICOLOGY REVIEWMUREAV 752,72,2013
TOXICOLOGY REVIEWNRTXDN 32,563,2011
TOXICOLOGY REVIEWREPTED 34,298,2012
TOXICOLOGY REVIEWMUREAV 752,153,2012
TOXICOLOGY REVIEWMUTAEX 23,143,2008
TOXICOLOGY REVIEWMUTAEX 23,171,2008
TOXICOLOGY REVIEWMUREAV 743-744,67,2013
TOXICOLOGY REVIEWEMMUEG 53,683,2012
TOXICOLOGY REVIEWMUREAV 753,147,2013
TOXICOLOGY REVIEWMUREAV 744,8,2012
TOXICOLOGY REVIEWMUREAV 759,27,2014
TOXICOLOGY REVIEWMUREAV 759,49,2014
TOXICOLOGY REVIEWEMMUEG 55,278,2014
TOXICOLOGY REVIEWTOLED5 199,203,2010
TOXICOLOGY REVIEWMUREAV 761,1,2014
TOXICOLOGY REVIEWMUREAV 750,31,2013
TOXICOLOGY REVIEWMUREAV 762,133,2014
TOXICOLOGY REVIEWMUTAEX 30,89,2014
TOXICOLOGY REVIEWMUTAEX 30,1,2015
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWMUREAV 763,181,2015
TOXICOLOGY REVIEWMUREAV 711,193,2011
TOXICOLOGY REVIEWMUREAV 711,123,2011
TOXICOLOGY REVIEWMUREAV 733,61,2012
TOXICOLOGY REVIEWMUREAV 733,100,2012
TOXICOLOGY REVIEWMUREAV 765,56,2015
TOXICOLOGY REVIEWMUREAV 776,31,2015
TOXICOLOGY REVIEWMUREAV 776,84,2015
TOXICOLOGY REVIEWMUREAV 776,118,2015
TOXICOLOGY REVIEWMUREAV 733,1,2012
TOXICOLOGY REVIEWMUTAEX 30,459,2015
TOXICOLOGY REVIEWMUTAEX 31,17,2016
TOXICOLOGY REVIEWMUREAV 793,176,2015
TOXICOLOGY REVIEWMUREAV 766,1,2015
TOXICOLOGY REVIEWMUREAV 764,16,2015
TOXICOLOGY REVIEWMUREAV 766,48,2015
TOXICOLOGY REVIEWMUREAV 767,67,2016
TOXICOLOGY REVIEWMUREAV 767,59,2016
TOXICOLOGY REVIEWMUREAV 743-744,160,2013
TOXICOLOGY REVIEWMUREAV 767,92,2016
TOXICOLOGY REVIEWMUREAV 767,8,2016
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWMUREAV 770,12,2016
TOXICOLOGY REVIEWMUREAV 770,119,I2

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,330,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 ppm (1.4 mg/m3)DTLVS* 3,131,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (1.4 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 ppm (1.4 mg/m3);KZW 2 ppm (2.8 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (1.4 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (1.4 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (1.4 mg/m3), short term exposure limit 3 ppm (4.2 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1 ppm (1.5 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 0.5 ppm (0.71 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (1.4 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (1.5 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 ppm (1.5 mg/m3);short term exposure limit 2 ppm (3 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (1.4 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (1.4 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (1,4 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 1 ppm (1.4 mg/m3), ceiling concentration 2 ppm (3 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.5 ppm (0.71 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1.4 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1 ppm (1.4 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1 ppm (1.4 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm (1.4 mg/m3);short term exposure limit 2 ppm (2.8 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 ppm (1.4 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 ppm (1.4 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 ppm (1.4 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 ppm (1.4 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDROGEN PEROXIDE-air10H time-weighted average 1.0 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 38605; Number of Industries 171; Total Number of Facilities 22930; Number of Occupations 142; Total Number of Employees Exposed 1006752; Total Number of Female Employees Exposed 727702
National Occupational Hazard Survey 1974Hazard Code 38605; Number of Industries 168; Total Number of Facilities 19597; Number of Occupations 83; Total Number of Employees Exposed 422227

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8799
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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