Hexane, 1,6-diisocyanato-

RTECS #
MO1740000
CAS #
822-06-0; 66368-96-5
See: NMAM or OSHA Methods
Updated
June 2018
Molecular Weight
168.22
Molecular Formula
C8H12N2O2
Synonyms
1,6-Diisocyanatohexane
1,6-Hexamethylene diisocyanate
1,6-Hexanediol diisocyanate
Desmodur H
Desmodur N
HDI
HDI-IC
Hexamethylendiisokyanat (Czech)
Hexamethylene diisocyanate
Hexamethylene diisocyanate (ACGIH)
Hexamethylene-1,6-diisocyanate
HMDI
Isocyanic acid, diester with 1,6-hexanediol
Isocyanic acid, hexamethylene ester
Metyleno-bis-fenyloizocyjanian (Polish)
Szesciometylenodwuizocyjanian (Polish)
TL 78

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, lung Inhibitor Concentration (20 percent kill): 1.1 mmol/LIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 30,274,2015
In Vitro/Human, lung fibroblast Inhibitor Concentration Low: 95 µmol/L/6HIn Vitro Toxicity Studies: Other assaysTIVIEQ 28,209,2014
In Vitro/Human, skin Inhibitor Concentration (20 percent kill): 40 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1127,2013
inhalation/mouse lethal concentration (50 percent kill): 30 mg/m385GMAT -,74,1982
inhalation/rat Lowest published lethal concentration: 60 mg/m3/4HEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 12(10),40,1968
inhalation/rat lethal concentration (50 percent kill): 124 mg/m3/4HTOSCF2 58,173,2000
inhalation/rat lethal concentration (50 percent kill): 462 mg/m3/4HLung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Other proteins
TOSCF2 58,173,2000
inhalation/rat lowest published toxic concentration: 15.9 mg/m3/6HLung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 58,173,2000
inhalation/rat lowest published toxic concentration: 54.3 mg/m3/6HLung, Thorax, or Respiration: Consolidation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Pleural effusion
TOSCF2 58,173,2000
inhalation/rat lowest published toxic concentration: 118.1 mg/m3/6HTOSCF2 58,173,2000
intravenous/mouse lethal dose (50 percent kill): 5600 µg/kgCSLNX* NX#07805
oral/mouse lethal dose (50 percent kill): 350 mg/kgTAKHAA 39,202,1980
oral/rat lethal dose (50 percent kill): 710 µL/kgAIHAAP 30,470,1969
skin/rabbit lethal dose (50 percent kill): 570 µL/kgAIHAAP 30,470,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 1 ppm/6H/5D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** OTS0571057
inhalation/mouse lowest published toxic concentration: 300 ppb/6H/5D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0571057
inhalation/mouse lowest published toxic concentration: 7.5 mg/m3/3D- intermittentImmunological Including Allergic: Increased immune response

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 261,103,2009
inhalation/rat lowest published toxic concentration: 0.05 ppm/6H/28D- intermittentOlfaction: Other olfaction effectsREPTED 14,135,2000
inhalation/rat lowest published toxic concentration: 0.05 ppm/6H/47D- intermittentOlfaction: Other olfaction effectsREPTED 14,135,2000
inhalation/rat lowest published toxic concentration: 0.05 ppm/20D- continuousOlfaction: Other olfaction effectsTJADAB 162,205,2000
inhalation/rat lowest published toxic concentration: 50 ppb/6H/30D- intermittentOlfaction: Other olfaction effectsREPTED 14,135,2000
inhalation/rat lowest published toxic concentration: 2 ppm/6H/5D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** OTS0571057
inhalation/rat lowest published toxic concentration: 40 ppb/6H/13W- intermittentOlfaction: Other olfaction effects

Eye: Conjunctiva irritation
NTIS** OTS0532755
inhalation/rat lowest published toxic concentration: 30 ppm/4H/2W- intermittentBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0555659
oral/rat lowest published toxic dose: 3 gm/kg/2W- intermittentGastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555659
skin/mouse lowest published toxic dose: 1 pph/3D- intermittentImmunological Including Allergic: Increased immune response

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 261,103,2009

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.005 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 140-141,213,2003
TOXICOLOGY REVIEWFCTOD7 55,596,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.02 mg(NCO)/m3, short term exposure limit 0.07 mg(NCO)/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.005 ppm (0.035 mg/m3);KZW 0.005 ppm (0.035 mg/m3), sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.005 ppm (0.034 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.005 ppm (0.035 mg/m3), MAY2011
Occupational Exposure Limit-FRANCEVME 0.01 ppm (0.075 mg/m3), VLE 0.02 ppm (0.15 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 0.005 ppm (0.035 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.035 mg/m3, short term exposure limit 0.035 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.005 ppm (0.03 mg/m3), short term exposure limit 0.01 ppm (0.07 mg/m3), sen, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.005 ppm (0.034 mg/m3), a1 sen, MAY2012
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.02 mg(NCO)/m3; short term exposure limit 0.07 mg(NCO)/m3, sen, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,005 ppm (0,034 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.05 mg/m3, short term exposure limit 0.15 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.05 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.002 ppm (0.02 mg/m3), ceiling concentration 0.005 ppm (0.03 mg/m3), Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.02 mg(NCO)/m3, skin, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.04 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HDI-air10H time-weighted average 0.035 mg/m3;ceiling concentration 0.14 mg/m3/10MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M4839; Number of Industries 21; Total Number of Facilities 1895; Number of Occupations 26; Total Number of Employees Exposed 19180; Total Number of Female Employees Exposed 329
National Occupational Hazard Survey 1974Hazard Code M4839; Number of Industries 9; Total Number of Facilities 238; Number of Occupations 12; Total Number of Employees Exposed 4490

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/102543/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isocyanates, monomeric, 5521
NIOSH Analytical Method, 1996: Isocyanates, 5522
On EPA IRIS database
OSHA ANALYTICAL METHOD #42
Page last reviewed: November 16, 2018