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Registry of Toxic Effects of Chemical Substances (RTECS)

4-Heptanone, 2,6-dimethyl-

RTECS #

MJ5775000

CAS #

108-83-8

Updated

September 2013

Molecular Weight

142.27

Molecular Formula

C9H18O

Synonyms

2,6-Dimethyl-4-heptanone
2,6-Dimethyl-4-heptanone (OSHA)
2,6-Dimethyl-heptan-4-on (Dutch,German)
2,6-Dimethylheptan-4-one
2,6-Dimetil-eptan-4-one (Italian)
Diisobutilchetone (Italian)
Diisobutyl ketone
Diisobutyl ketone (ACGIH:OSHA)
Di-isobutylcetone (French)
Diisobutylketon (Dutch, German)
Isobutyl ketone
Isovalerone
s-Diisopropylacetone
sym-Diisopropylacetone
Valerone

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 25 ppm/15M mildJIHTAB 28,262,1946
eye /rabbit 500 mg mildAJOPAA 29,1363,1946
skin /rabbit 10 mg/24H open irritation test mildJIHTAB 31,60,1949
skin /rabbit 500 mg open irritation test mildUCDS** 12/15/1971

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 50 ppmEye: Other eye effects

Behavioral: Headache

Gastrointestinal: Nausea or vomiting
NPIRI* 1,23,1974
inhalation/mouse lowest published toxic concentration: 1813 mg/m3/4HBehavioral: Alteration of classical conditioningVCVGK* -,432,1994
inhalation/rat Lowest published lethal concentration: 11620 mg/m3/8HVCVGK* -,432,1994
inhalation/rat Lowest published lethal concentration: 2000 ppm/4HJIHTAB 31,343,1949
oral/mouse lethal dose (50 percent kill): 1416 mg/kgSCCUR* -,4,1961
oral/rat lethal dose (50 percent kill): 5750 mg/kgNPIRI* 1,23,1974
skin/rabbit lethal dose (50 percent kill): 16120 mg/kgJIHTAB 31,60,1949

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 250 ppm/7H/6W- intermittentLiver: Changes in liver weightAMIHBC 8,377,1953
inhalation/guinea pig lowest published toxic concentration: 9590 mg/m3/7H/30D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,432,1994
inhalation/guinea pig lowest published toxic concentration: 1450 mg/m3/7H/30D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
VCVGK* -,432,1994
inhalation/rat lowest published toxic concentration: 1450 mg/m3/7H/30D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
VCVGK* -,432,1994
inhalation/rat lowest published toxic concentration: 9590 mg/m3/7H/30D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,432,1994
inhalation/rat lowest published toxic concentration: 98 ppm/6H/9D- intermittentBehavioral: Fluid intake

Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition
TIHEEC 3,443,1987
inhalation/rat lowest published toxic concentration: 250 ppm/7H/6W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
AMIHBC 8,377,1953
oral/rat lowest published toxic dose: 30 gm/kg/3W- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Changes in liver weight
NTIS** OTS0571116
oral/rat lowest published toxic dose: 130 gm/kg/13W- intermittentLiver: Changes in liver weight

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0571116
oral/rat lowest published toxic dose: 130000 mg/kg/90D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in adrenal weight
HPV275 -,-,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 25 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWNTAPM* -,753,1995

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,322,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 25 ppm (150 mg/m3)DTLWS* 3,16,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 25 ppm (145 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (290 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 25 ppm (147 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 25 ppm (150 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 25 ppm (150 mg/m3), short term exposure limit 40 ppm (240 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 25 ppm (250 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 25 ppm (150 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 25 ppm (150 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 25 ppm (145 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 25 ppm (145 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 25 ppm (145 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 150 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 25 ppm (150 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 150 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 50 ppm (290 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 50 ppm (290 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 25 ppm (148 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 50 ppm (290 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 50 ppm (290 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 50 ppm (290 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 50 ppm (290 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIISOBUTYL KETONE-air10H time-weighted average 25 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 25820; Number of Industries 66; Total Number of Facilities 6204; Number of Occupations 59; Total Number of Employees Exposed 72926; Total Number of Female Employees Exposed 14857
National Occupational Hazard Survey 1974Hazard Code 25820; Number of Industries 56; Total Number of Facilities 7290; Number of Occupations 49; Total Number of Employees Exposed 55554

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones I, 1300
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