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Registry of Toxic Effects of Chemical Substances (RTECS)

Fibrous glass

RTECS #

LK3651000

CAS #

65997-17-3; 94551-77-6

Updated

July 2014

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

475' glass fibres
E-glass fibres
Fiberglass
Fibrous glass (OSHA)
Fibrous glass dust (ACGIH)
Glass
Glass fibers

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testlung/hamster2 µg/cm2MUREAV 391,111,1997
other mutation test systemsovary/hamster10 mg/LMUREAV 116,369,1983
other mutation test systemsfibroblast/human10 mg/LMUREAV 116,369,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/mouse toxic dose: 1600 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
BJURAN 36,225,1964
implant/rat lowest published toxic dose: 200 mg/kgTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
JJIND8 67,965,1981
implant/rat toxic dose: 200 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
IARCCD 8,289,1973
inhalation/rat lowest published toxic concentration: 5 mg/m3/7H/90W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTIS** PB83-258111
intraperitoneal/hamster lowest published toxic dose: 400 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
IAPUDO 30,337,1980
intraperitoneal/rabbit lowest published toxic dose: 25 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
IAPUDO 30,337,1980
intraperitoneal/rat lowest published toxic dose: 50 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
IAPUDO 30,337,1980
intrapleural/rat toxic dose: 100 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
IAPUDO 30,311,1980
intratracheal/hamster lowest published toxic dose: 125 mg/kg/5W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
ENVRAL 54,52,1991

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, endothelium Inhibitor Concentration Low: 0.25 cm2/cm2/7DIn Vitro Toxicity Studies: Other assaysTXCYAC 288,34,2011
In Vitro/Human, skin Inhibitor Concentration Low: 0.25 cm2/cm2/4DIn Vitro Toxicity Studies: Other assaysTXCYAC 288,34,2011
intratracheal/mouse Lethal dose: >20 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
ARDSBL 141(Suppl),A3-A937,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lowest published toxic concentration: 30 mg/m3/6H/13W- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOXID9 36(1 Pt2),7,1997
inhalation/hamster lowest published toxic concentration: 30 mg/m3/6H/78W- intermittentLung, Thorax, or Respiration: Other changesTOXID9 42,178,1998
inhalation/rat lowest published toxic concentration: 16 mg/m3/6H/13W- intermittentLung, Thorax, or Respiration: Other changesFAATDF 32,31,1996

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 f/cubic centimeter (resp fibers)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 81,-,2002
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 81,-,2002

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDNUISANCE PARTICULATES (fibrous or dust)DTLVS* 3,114,1971
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3 (dust), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 f/cc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 f/cc, NOV2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 mg/m3, inhal. dust, NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 1 f/cc, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 1 fcc, 2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3 (dust), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 f/cc (respirable fibers), 5 mg/m3 (inspirable dust), JAN2002
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FIBROUS GLASS-air10H time-weighted average 3 million fb/m3NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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