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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethylene, 1,1-difluoro-

RTECS #

KW0560000

CAS #

75-38-7

Updated

September 2013

Molecular Weight

64.04

Molecular Formula

C2H2F2

Synonyms

1,1-Difluoroethene
Ethene, 1,1-difluoro-
Halocarbon 1132A
NCI-C60208
VDF
Vinylidene difluoride
Vinylidene fluoride

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium50 pph/24H (-enzymatic activation step)ARTODN 41,249,1979

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1930 mg/kg/52W- intermittentTumorigenic: Neoplastic by RTECS criteria

Ear: Tumors

Skin and Appendages: Tumors
MELAAD 70,363,1979
oral/rat lowest published toxic dose: 857 mg/kg/130W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
VCVGH* -,287,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 800 ppb/4HNTIS** OTS0523847
inhalation/rat lethal concentration (50 percent kill): 240000 mg/m3/4HVCVGH* -,287,1990
inhalation/rat Lowest published lethal concentration: 128000 ppm/4HLung, Thorax, or Respiration: Other changesJOCMA7 4,262,1962

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 40000 ppm/6H/13W- intermittentBehavioral: Excitement

Blood: Pigmented or nucleated red blood cells

Skin and Appendages: Other: Hair
NTIS** OTS0522815
inhalation/rat lowest published toxic concentration: 1500 ppm/6H/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0523847

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 500 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 39,227,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate DataIMEMDT 71,1551,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 39,227,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1551,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1551,1999
TOXICOLOGY REVIEWENTOX* -,43,2005
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWFCTOD7 49,1877,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 500 ppm (1330 mg/m3), MAR2002

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYLIDENE FLUORIDE-airuse 29 Code of Federal Regulations (CFR) 1910.1017NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 80234; Number of Industries 2; Total Number of Facilities 41; Number of Occupations 4; Total Number of Employees Exposed 1467

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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