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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-methoxy-, acetate

RTECS #

KL5950000

CAS #

110-49-6

Updated

July 2016

Molecular Weight

118.15

Molecular Formula

C5H10O3

Synonyms

2-Methoxyaethylacetat (German)
2-Methoxyethanol acetate
2-Methoxyethanol, acetate
2-Methoxy-ethyl acetaat (Dutch)
2-Methoxyethyl acetate
2-Methoxyethyl acetate (ACGIH:OSHA)
2-Methoxyethyle, acetate de (French)
2-Methoxyethylester kyseliny octove (Czech)
2-Metossietilacetato (Italian)
Acetate de l'ether monomethylique de l'ethylene-glycol (French)
Acetate de methyle glycol (French)
Acetato di metil cellosolve (Italian)
Acetic acid 2-methoxyethyl ester
Aethylenglykolmethylaetheracetat (German)
EGMEA
Ethylene glycol methyl acetate (OSHA)
Ethylene glycol methyl ether acetate
Ethylene glycol monomethyl ether acetate
Glycol ether EM acetate
Glycol monomethyl ether acetate
MeCsac
Methyl cellosolve acetate
Methyl cellosolve acetate (OSHA)
Methyl cellosolye acetaat (Dutch)
Methyl glycol acetate
Methyl glycol monoacetate
Methylcelosolvacetat (Czech)
Methylglykolacetat (German)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 218 mg mildUCDS** 3/20/1973

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster32000 ppmMUREAV 259,147,1991
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae56600 ppmMUREAV 149,339,1985

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 12500 mg/kg (25D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductSAIGBL 21,29,1979
oral/mouse 50 gm/kg (25D male)Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsSAIGBL 21,29,1979
oral/mouse 9800 mg/kg (7-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)NTIS** PB86-197605
oral/mouse 9800 mg/kg (6-13D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)TCMUD8 7,29,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 6 gm/m3/7HEye: Lacrimation

Behavioral: Food intake (animal)

Gastrointestinal: Changes in structure or function of salivary glands
AGGHAR 5,1,1933
inhalation/human lowest published toxic concentration: 1000 mg/m3Eye: Lacrimation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes
AGGHAR 5,1,1933
inhalation/mammal (species unspecified) lowest published toxic concentration: 1014 mg/m3/4HBehavioral: Alteration of classical conditioning

Kidney, Ureter, and Bladder: Other changes in urine composition
TOVEFN (1),28,1996
inhalation/rat Lowest published lethal concentration: 7000 ppm/4HJIHTAB 30,63,1948
intraperitoneal/rat lowest published lethal dose: 1200 mg/kgBehavioral: General anesthetic

Behavioral: Muscle weakness

Kidney, Ureter, and Bladder: Renal function tests depressed
JPPMAB 11,150,1959
oral/guinea pig lethal dose (50 percent kill): 1250 mg/kgBehavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/mouse lethal dose (50 percent kill): 3100 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),27,1996
oral/mouse lethal dose (50 percent kill): 3100 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),28,1996
oral/rat lethal dose (50 percent kill): 2900 mg/kgTOVEFN (1),28,1996
oral/rat lethal dose (16 percent kill): 2600 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),28,1996
oral/rat lowest published lethal dose: 3200 mg/kgTOVEFN (1),28,1996
oral/rat lethal dose (50 percent kill): 2900 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),27,1996
skin/rabbit lethal dose (50 percent kill): 5250 µL/kgUCDS** 3/20/1973
subcutaneous/cat lowest published lethal dose: 3 gm/kgBehavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
AGGHAR 5,1,1933
subcutaneous/guinea pig lowest published lethal dose: 5 gm/kgBehavioral: Somnolence (general depressed activity)AGGHAR 5,1,1933

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCRTXB2 30,307,2000
TOXICOLOGY REVIEWFCTOD7 55,596,2013
TOXICOLOGY REVIEWREPTED 58,252,2015

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 25 ppm (120 mg/m3) (skin)DTLVS* 3,159,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 ppm (24 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (25 mg/m3);KZW 20 ppm (100 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (24 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (24 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 ppm (2.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 5 ppm (24 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 1 ppm (4.9 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 25 mg/m3, short term exposure limit 100 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (24 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 ppm (0.48 mg/m3), skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (24 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 ppm (16 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (24 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (24 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 25 mg/m3, MAC(short term exposure limit) 100 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (4.9 mg/m3), KZG-week 8 ppm (39.2 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1.5 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 25 ppm (120 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 25 ppm (120 mg/m3), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 ppm (25 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 25 ppm (120 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 25 ppm (120 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 25 ppm (120 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 25 ppm (120 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EGMEA-air10H time-weighted average 0.1 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 46935; Number of Industries 20; Total Number of Facilities 658; Number of Occupations 27; Total Number of Employees Exposed 9892; Total Number of Female Employees Exposed 2801
National Occupational Hazard Survey 1974Hazard Code 46935; Number of Industries 45; Total Number of Facilities 2907; Number of Occupations 49; Total Number of Employees Exposed 20492

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl cellosolve acetate, 1451
OSHA ANALYTICAL METHOD #53
OSHA ANALYTICAL METHOD #79
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