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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-methoxy-

RTECS #

KL5775000

CAS #

109-86-4

Updated

July 2016

Molecular Weight

76.11

Molecular Formula

C3H8O2

Synonyms

2-Methoxy-aethanol (German)
2-Methoxyethanol
2-Methoxyethanol (ACGIH:OSHA)
2-Metossietanolo (Italian)
Aethylenglykol-monomethylaether (German)
Dowanol 7
Dowanol EM
EGME
Ether monomethylique de l'ethylene-glycol (French)
Ethylene glycol methyl ether
Ethylene glycol monomethyl ether
Glycol ether EM
Glycol monomethyl ether
Glycolmethyl ether
Jeffersol EM
Methoxyethanol
Methoxyhydroxyethane
Methyl cellosolve
Methyl cellosolve (OSHA)
Methyl cellosolve methyl glycol
Methyl ethoxol
Methyl glycol
Methyl oxitol
Methylcelosolv (Czech)
Methylglykol (German)
Metil cellosolve (Italian)
Metoksyetylowy alkohol (Polish)
Monomethyl ether of ethylene glycol
Poly-Solv EM
Prist

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /guinea pig 10 µg mildJPPMAB 11,150,1959
eye /rabbit 97 mgTXAPA9 19,276,1971
eye /rabbit 500 mg/24H mild85JCAE -,623,1986
skin /rabbit 483 mg/24H mildTXAPA9 19,276,1971

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human150 mmol/LMUREAV 320,125,1994
DNA Damageoral/rat800 mg/kg/4D- intermittentTOXID9 44,114,2005
Dominant Lethal Testoral/rat500 mg/kgENMUDM 6,390,1984
sperm morphologyoral/rat500 mg/kgENMUDM 6,390,1984
sperm morphologyoral/mouse500 mg/kgENMUDM 6,390,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 68 mg/kg/4H (1-19D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
FAVUAI 21,30,1989
inhalation/rat 30 ppm/6H (65D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductFAATDF 3,49,1983
inhalation/rat 100 ppm/6H (6-17D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
TXAPA9 69,43,1983
inhalation/rat 100 ppm/6H (6-17D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXAPA9 69,43,1983
inhalation/rat 30 ppm/6H (13W male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FAATDF 3,80,1983
inhalation/mouse 1000 ppm/6H (11D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductTXAPA9 61,368,1981
inhalation/mouse 500 ppm/7H (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TXAPA9 70,303,1983
inhalation/mouse 50 ppm/6H (6-15D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Urogenital system
TXAPA9 75,409,1984
inhalation/mouse 50 ppm/6H (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
EVHPAZ 57,7,1984
inhalation/rabbit 300 ppm/6H (65D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductFAATDF 3,49,1983
inhalation/rabbit 50 ppm/6H (6-18D pregnant)Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system
TXAPA9 75,409,1984
inhalation/rabbit 50 ppm/6H (6-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EVHPAZ 57,7,1984
inhalation/rabbit 10 ppm/6H (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 75,409,1984
inhalation/rat 933 mg/m3 (6-17D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
VCVGK* -,160,1994
intraperitoneal/rat 330 mg/kg (12D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
TJADAB 29(2),54A,1984
intraperitoneal/rat 190 mg/kg (14D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Urogenital system
JJATDK 4,35,1984
intraperitoneal/rat 190 mg/kg (12D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJJATDK 4,35,1984
intraperitoneal/rat 190 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)JJATDK 4,35,1984
intravenous/mouse 250 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemTOXID9 12,101,1992
oral/monkey 930 mg/kg (20-45D pregnant)Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 35,66A,1987
oral/monkey 633 mg/kg (20-45D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 35,66A,1987
oral/hamster 1562 mg/kg (25D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductEVHPAZ 57,75,1984
oral/mouse 11200 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)EVHPAZ 57,141,1984
oral/guinea pig 6250 mg/kg (25D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductEVHPAZ 57,75,1984
oral/rat 250 mg/kg (13D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 145,415,1997
oral/mouse 175 mg/kg (11D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTJADAB 31,48A,1985
oral/mouse 2 gm/kg (7-14D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system
TXCYAC 20,335,1981
oral/mouse 500 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 80,108,1985
oral/mouse 250 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 80,108,1985
oral/mouse 6250 mg/kg (25D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductSAIGBL 21,29,1979
oral/rat 175 mg/kg (7-13D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) systemTJADAB 32,33,1985
oral/rat 175 mg/kg (7-13D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Biochemical and metabolic
DCTODJ 9,1,1986
oral/rat 15015 mg/kg (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTPTR* NIH-93-3349
oral/rat 100 mg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductTXAPA9 69,385,1983
oral/rat 350 mg/kg (9-15D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
TXAPA9 86,197,1986
oral/rat 1000 mg/kg (6-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
VCVGK* -,160,1994
oral/mouse 1000 mg/kg (6-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
VCVGK* -,160,1994
oral/rabbit 1000 mg/kg (6-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
VCVGK* -,160,1994
oral/rat 350 mg/kg (9-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 82,197,1986
oral/rat 350 mg/kg (9-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
TXAPA9 82,197,1986
oral/mouse 2 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB89152565
oral/mouse 4.45 gm/kg (7D prior to copulation/21D pregnant)Reproductive: Maternal effects: PostpartumNTIS** #PB86163136
oral/rat 5.5 gm/kg (21W male)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)NTIS** #PB90252321/AS
oral/mouse 5.6 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)NTIS** #PB86163136
oral/mouse 7.2 gm/kg (7D male/7D pre-1D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB88192240
oral/mouse 8.4 gm/kg (7D male/7D prior to copulation)Reproductive: Effects on fertility: Other measures of fertilityNTIS** #PB88192240
oral/mouse 11.8 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB86163136
oral/mouse 14 gm/kg (14D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)NTIS** #PB86163136
oral/mouse 14 gm/kg (14D prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)NTIS** #PB86163136
oral/mouse 17.5 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
NTIS** #PB89152565
oral/mouse 35.28 gm/kg (15W prior to copulation)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB86163136
oral/rat 36.75 gm/kg (21W male/21W prior to copulation)Reproductive: Effects on fertility: Other measures of fertilityNTIS** #PB90252321/AS
oral/mouse 43 gm/kg (15W male/15W pre-3W after birth)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB89152565
oral/rat 30 mg/kg (multigenerations)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Sex ratio
NTIS** #PB90252321
oral/rat 37.5 mg/kg (multigenerations)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)NTIS** #PB90252321/AS
oral/mouse 50 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital systemNTIS** #PB89152565
oral/mouse 159 mg/kg (multigenerations)Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
NTIS** #PB86163136
oral/mouse 159 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary systemNTIS** #PB86163136
oral/mouse 170 mg/kg (multigenerations)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)NTIS** #PB89152565
oral/rat 1050 mg/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Sex ratio
NTIS** #PB90252321
oral/rat 3570 mg/kg (17W male)Reproductive: Effects on newborn: Sex ratioNTIS** #PB90252321
oral/mouse 19 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Other measures of fertilityNTIS** #PB88211446
oral/rat 15 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB90252321
oral/mouse 200 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB88211446
oral/rat 262 mg/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)NTIS** #PB90252321
oral/mouse 60 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB88211446
oral/rat 750 mg/kg (18D prior to copulation/0-6D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Other measures of fertility
JTSCDR 34,SP121,2009
oral/rat 2400 mg/kg (17D prior to copulation/0-6D pregnant)Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
JTSCDR 34,SP121,2009
oral/rat 7800 mg/kg (19D prior to copulation/0-6D pregnant)Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
JTSCDR 34,SP121,2009
oral/rat 150 mg/kg (3D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductTOLED5 190,193,2009
skin/rat 11592 mg/kg (6-17D pregnant)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on embryo or fetus: Fetal death
JJATDK 6,165,1986
skin/rat 4375 mg/kg (7D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
TXAPA9 100,145,1989
skin/rat 2 gm/kg (10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FAATDF 15,448,1990
skin/rat 1 gm/kg (12D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Gastrointestinal system
FAATDF 15,448,1990
skin/guinea pig 65 gm/kg (65D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductFAATDF 6,339,1986
skin/rat 2.5 mg/kg (7-16D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
VCVGK* -,159,1994
subcutaneous/mouse 1200 mg/kg (7-13D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOLED5 50,263,1990
subcutaneous/mouse 3200 mg/kg (7-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TOLED5 50,263,1990
subcutaneous/mouse 250 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TJADAB 54,219,1996
subcutaneous/rat 600 mg/kg (6-20D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
EVHPAZ 57,199,1984
subcutaneous/rat 440 mg/kg (7-17D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)TCMUD8 7,73,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 414 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Rat, embryo Inhibitor Concentration Low: 200 mmol/L/48HReproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TIVIEQ 7,777,1993
In Vitro/Rat, embryo Inhibitor Concentration Low: 50 mmol/L/48HReproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
TIVIEQ 7,777,1993
In Vitro/Rat, embryo Inhibitor Concentration Low: 50 mmol/L/48HReproductive: Other effects to embryo or fetusTIVIEQ 7,777,1993
inhalation/human lowest published toxic concentration: 25 ppmBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
JIHTAB 20,134,1938
inhalation/mouse lethal concentration (50 percent kill): 1480 ppm/7HBehavioral: Analgesia

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria
JIHTAB 25,157,1943
inhalation/mouse lethal concentration (50 percent kill): 4600 ppmENTOX* -,63,2005
inhalation/rat lowest published toxic concentration: 625 ppm/4HReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)ATSUDG 7,167,1984
inhalation/rat lowest published toxic concentration: 1000 ppm/4HReproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
ATSUDG 7,167,1984
inhalation/rat lethal concentration (50 percent kill): 1500 ppm/7HNPIRI* 1,57,1974
intraperitoneal/mouse lethal dose (50 percent kill): 2147 mg/kgKidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in spleen

Blood: Other changes
FEPRA7 6,342,1947
intraperitoneal/rat lethal dose (50 percent kill): 2500 mg/kgNPIRI* 1,57,1974
intraperitoneal/rat lowest published toxic dose: 50 mg/kgReproductive: Effects on fertility: Other measures of fertilityREPTED 14,45,2000
intraperitoneal/rat lowest published toxic dose: 150 mg/kgReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVGK* -,159,1984
intravenous/rat lethal dose (50 percent kill): 2068 mg/kgBlood: Other hemolysis with or without anemiaAMIHAB 14,114,1956
oral/guinea pig lethal dose (50 percent kill): 950 mg/kgBehavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/guinea pig lowest published toxic dose: 200 mg/kgReproductive: Paternal effects: Testes, epididymis, sperm ductEXMPA6 61,119,1994
oral/guinea pig lowest published toxic dose: 300 mg/kgBlood: Other changesEXMPA6 61,119,1994
oral/human lowest published lethal dose: 3380 mg/kgGastrointestinal: Gastritis

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 28,267,1946
oral/human lowest published lethal dose: 143 mg/kgVCVGK* -,159,1984
oral/mouse lethal dose (50 percent kill): 2800 mg/kgBehavioral: Somnolence (general depressed activity)

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,159,1984
oral/mouse lethal dose (50 percent kill): 2560 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Cardiac: Other changes
GTPZAB 32(3),48,1988
oral/rabbit lethal dose (50 percent kill): 890 mg/kgBehavioral: General anesthetic

Blood: Other hemolysis with or without anemia
AMIHAB 14,114,1956
oral/rabbit lethal dose (50 percent kill): 890 mg/kgBehavioral: Somnolence (general depressed activity)

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,159,1984
oral/rat lethal dose (50 percent kill): 2460 mg/kgBehavioral: Somnolence (general depressed activity)

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,159,1984
oral/rat lowest published toxic dose: 250 mg/kgRelated to Chronic Data: Changes in prostate weightREPTED 6,491,1992
oral/rat lethal dose (50 percent kill): 2370 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Other changes
VHTODE 29,361,1987
oral/rat lowest published toxic dose: 2000 mg/kgReproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTSCDR 32,515,2007
oral/rat lowest published toxic dose: 50 mg/kgReproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JTSCDR 32,515,2007
oral/rat lowest published toxic dose: 200 mg/kgBlood: Normocytic anemia

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
EXMPA6 61,119,1994
oral/rat lowest published toxic dose: 150 mg/kgReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JOAND3 5,369,1984
oral/rat lowest published toxic dose: 200 mg/kgReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TOXID9 44,114,2005
skin/rabbit lethal dose (50 percent kill): 2000 mg/kgKidney, Ureter, and Bladder: Urine volume decreased or anuriaVCVGK* -,159,1984
skin/rabbit lethal dose (50 percent kill): 1280 mg/kgNPIRI* 1,57,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 750 ppm/7H/12W- intermittentBlood: Microcytosis with or without anemia

Blood: Other changes
JIHTAB 25,409,1943
inhalation/Dog lowest published toxic concentration: 2500 mg/m3/7H/60D- intermittentBlood: Changes in spleen

Blood: Microcytosis with or without anemia
VCVGK* -,160,1994
inhalation/mammal (species unspecified) lowest published toxic concentration: 1240 mg/m3/6H/5D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Brain and Coverings: Other degenerative changes
VCVGK* -,159,1994
inhalation/mouse lowest published toxic concentration: 3680 mg/m3/6H/9D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductVCVGK* -,159,1994
inhalation/mouse lowest published toxic concentration: 1000 ppm/6H/11D- intermittentBlood: Changes in leukocyte (WBC) count

Related to Chronic Data: Changes in testicular weight
TXAPA9 61,368,1981
inhalation/mouse lowest published toxic concentration: 3680 mg/m3/6H/9D- intermittentSpinal Cord: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,159,1994
inhalation/rabbit lowest published toxic concentration: 300 ppm/6H/13W- intermittentEndocrine: Changes in thymus weight

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Changes in testicular weight
FAATDF 3,49,1983
inhalation/rat lowest published toxic concentration: 300 ppm/6H/13W- intermittentBlood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
FAATDF 3,49,1983
inhalation/rat lowest published toxic concentration: 970 mg/m3/7H/5W- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in spleen
JIHTAB 25,374,1943
inhalation/rat lowest published toxic concentration: 1000 ppm/6H/11D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in bone marrow not included in above

Blood: Changes in leukocyte (WBC) count
TXAPA9 61,368,1981
inhalation/rat lowest published toxic concentration: 400 ppm/6H/2W- intermittentBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ENVRAL 22,423,1980
inhalation/rat lowest published toxic concentration: 3680 mg/m3/6H/9D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductVCVGK* -,159,1994
inhalation/rat lowest published toxic concentration: 3680 mg/m3/6H/9D- intermittentSpinal Cord: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,159,1994
inhalation/rat lowest published toxic concentration: 1100 mg/m3/10D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
VCVGK* -,160,1994
intraperitoneal/rat lowest published toxic dose: 450 mg/kg/16D- intermittentBlood: Changes in other cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TIHEEC 9,617,1993
oral/guinea pig lowest published toxic dose: 600 mg/kg/3D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)EXMPA6 61,119,1994
oral/mouse lowest published toxic dose: 12110 mg/kg/2W- continuousEndocrine: Changes in thymus weight

Related to Chronic Data: Changes in testicular weight
NTPTR* NIH-93-3349
oral/mouse lowest published toxic dose: 82 gm/kg/13W- continuousEndocrine: Effect on menstrual cycle

Endocrine: Other changes

Blood: Changes in spleen
NTPTR* NIH-93-3349
oral/mouse lowest published toxic dose: 11200 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEVHPAZ 57,141,1984
oral/mouse lowest published toxic dose: 8820 mg/kg/21W- continuousKidney, Ureter, and Bladder: Changes in kidney weightNTIS** #PB88211446
oral/mouse lowest published toxic dose: 29400 mg/kg/21W- continuousLiver: Changes in liver weightNTIS** #PB88211446
oral/mouse lowest published toxic dose: 80850 mg/kg/21W- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
NTIS** #PB88211446
oral/mouse lowest published toxic dose: 8820 mg/kg/21W- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** #PB88211446
oral/mouse lowest published toxic dose: 126000 mg/kg/15W- continuousReproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB89152565
oral/mouse lowest published toxic dose: 17850 mg/kg/15W- continuousLiver: Changes in liver weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
NTIS** #PB89152565
oral/mouse lowest published toxic dose: 6300 mg/kg/15W- continuousLiver: Changes in liver weightNTIS** #PB88192240
oral/mouse lowest published toxic dose: 4200 mg/kg/7D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB88192240
oral/mouse lowest published toxic dose: 4200 mg/kg/7D- continuousReproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
NTIS** #PB88192240
oral/mouse lowest published toxic dose: 9800 mg/kg/49D- continuousLiver: Changes in liver weight

Reproductive: Maternal effects: Ovaries, fallopian tubes
NTIS** #PB88192240
oral/mouse lowest published toxic dose: 21665 mg/kg/28D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB86163136
oral/mouse lowest published toxic dose: 35280 mg/kg/15W- continuousReproductive: Maternal effects: Menstrual cycle changes or disordersNTIS** #PB86163136
oral/rat lowest published toxic dose: 1400 mg/kg/1W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJTSCDR 25,259,2000
oral/rat lowest published toxic dose: 2800 mg/kg/2W- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
JTSCDR 25,259,2000
oral/rat lowest published toxic dose: 200 mg/kg/2D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)EXMPA6 40,169,1984
oral/rat lowest published toxic dose: 600 mg/kg/3D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)EXMPA6 61,119,1994
oral/rat lowest published toxic dose: 900 mg/kg/3D- intermittentReproductive: Maternal effects: Menstrual cycle changes or disordersTXAPA9 142,328,1997
oral/rat lowest published toxic dose: 4500 mg/kg/15D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightTXAPA9 142,328,1997
oral/rat lowest published toxic dose: 1050 mg/kg/2W- continuousReproductive: Maternal effects: Oogenesis

Reproductive: Effects on fertility: Other measures of fertility
REPTED 14,45,2000
oral/rat lowest published toxic dose: 29484 mg/kg/13W- continuousEndocrine: Changes in thymus weight

Blood: Changes in platelet count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NIH-93-3349
oral/rat lowest published toxic dose: 10206 mg/kg/21D- continuousEndocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
FAATDF 16,830,1991
oral/rat lowest published toxic dose: 500 mg/kg/10D- intermittentEndocrine: Changes in thymus weight

Immunological Including Allergic: Decreased immune response
TXAPA9 109,494,1991
oral/rat lowest published toxic dose: 500 mg/kg/10D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
VCVGK* -,160,1994
oral/rat lowest published toxic dose: 4200 mg/kg/60D- intermittentEndocrine: Changes in thymus weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
HPV004 -,-,2001
oral/rat lowest published toxic dose: 40500 mg/kg/60D- intermittentEndocrine: Changes in thymus weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV004 -,-,2001
oral/rat lowest published toxic dose: 4200 mg/kg/2W- intermittentEndocrine: Changes in adrenal weight

Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders
JTSCDR 34,SP121,2009
oral/rat lowest published toxic dose: 2800 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in adrenal weight

Reproductive: Maternal effects: Menstrual cycle changes or disorders
JTSCDR 34,SP121,2009
oral/rat lowest published toxic dose: 840 mg/kg/4W- intermittentEndocrine: Changes in adrenal weightJTSCDR 34,SP121,2009
oral/rat lowest published toxic dose: 1400 mg/kg/2W- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaJTSCDR 34,SP121,2009
oral/rat lowest published toxic dose: 7800 mg/kg/26D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJTSCDR 34,SP121,2009
oral/rat lowest published toxic dose: 3900 mg/kg/13D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJTSCDR 34,SP121,2009
oral/rat lowest published toxic dose: 700 mg/kg/7D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Changes in: Ca

Related to Chronic Data: Changes in uterine weight
TXAPA9 82,197,1986
oral/rat lowest published toxic dose: 1200 mg/kg/8D- intermittentRelated to Chronic Data: Changes in testicular weightJOAND3 5,369,1984
skin/guinea pig lowest published toxic dose: 65 gm/kg/13W- intermittentBlood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
FAATDF 6,339,1986
skin/rat lowest published toxic dose: 3200 mg/kg/4D- intermittentEndocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
TXCYAC 98,215,1995
skin/rat lowest published toxic dose: 20 gm/kg/4W- intermittentBlood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Changes in testicular weight
TXCYAC 57,209,1989
subcutaneous/rat lowest published toxic dose: 1902.75 mg/kg/4W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainARTODN 82,125,2008
subcutaneous/rat lowest published toxic dose: 3805.5 mg/kg/4W- intermittentBlood: Luekopenia

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARTODN 82,125,2008
unreported route/rat lowest published toxic dose: 150 mg/kg/3D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Other
TOXID9 90,219,2006

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFAATDF 13,747,1989
TOXICOLOGY REVIEWCRTXB2 30,307,2000
TOXICOLOGY REVIEWJTSCDR 25,1,2000
TOXICOLOGY REVIEWCRTXB2 33,137,2003
TOXICOLOGY REVIEWENTOX* -,451,2005
TOXICOLOGY REVIEWENTOX* -,63,2005
TOXICOLOGY REVIEWHUTOX* -,623,1996
TOXICOLOGY REVIEWJTSCDR 34,SP1,2009
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWREPTED 33,269,2012
TOXICOLOGY REVIEWREPTED 58,252,2015

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,241,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 25 ppm (80 mg/m3) (skin)DTLVS* 3,158,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 ppm (16 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (15 mg/m3);KZW 20 ppm (60 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (16 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (16 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 ppm (1.6 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 5 ppm (16 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 1 ppm (3.2 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 15 mg/m3, short term exposure limit 60 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (16 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 ppm (0.31 mg/m3), skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (16 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 25 ppm (80 mg/m3);short term exposure limit 35 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (16 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (16 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (16 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 15 mg/m3, MAC(short term exposure limit) 60 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 5 ppm, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (3.2 mg/m3), KZG-week 8 ppm (25.6 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 25 ppm (80 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 25 ppm (80 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 ppm (16 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 25 ppm (80 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 25 ppm (80 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 25 ppm (80 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 25 ppm (80 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENEGLYCOL MONOMETHYL ETHER-air10H time-weighted average 0.1 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 46240; Number of Industries 89; Total Number of Facilities 8042; Number of Occupations 86; Total Number of Employees Exposed 168180; Total Number of Female Employees Exposed 53403
National Occupational Hazard Survey 1974Hazard Code 46240; Number of Industries 128; Total Number of Facilities 11165; Number of Occupations 102; Total Number of Employees Exposed 103424

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9101
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols IV, 1403
NIOSH CURRENT INTELLIGENCE BULLETIN, #39
NTP Toxicity studies, RPT# TOX-26, October 2000
On EPA IRIS database
OSHA ANALYTICAL METHOD #53
OSHA ANALYTICAL METHOD #79
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