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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2,2'-iminodi-

RTECS #

KL2975000

CAS #

111-42-2

Updated

October 2016

Molecular Weight

105.16

Molecular Formula

C4H11NO2

Synonyms

2-(2-Hydroxyethylamino)ethanol
2,2'-Dihydroxydiethylamine
2,2'-Iminobisethanol
2,2'-Iminodiethanol
Bis(2-hydroxyethyl)amine
DEA
Di(2-hydroxyethyl)amine
Diaethanolamin (German)
Diethanolamin (Czech)
Diethanolamine
Diethanolamine (ACGIH)
Diethylamine, 2,2'-dihydroxy-
Diethylolamine
Diolamine
NCI-C55174

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5500 mg severeAJOPAA 29,1363,1946
eye /rabbit 750 µg/24H severe85JCAE -,685,1986
skin /rabbit 50 mg open irritation test mildUCDS** 12/29/1971
skin /rabbit 500 mg/24H mild85JCAE -,685,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
specific locus testother cell types/human90 mg/L/16H (-enzymatic activation step)MUREAV 724,76,2011
Unscheduled DNA Synthesisliver/rat10 mg/L/24HTOXID9 72,238,2003
Unscheduled DNA Synthesisliver/mouse10 mg/L/24HTOXID9 72,238,2003

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 200 mg/m3/6H (6-15D pregnant)Reproductive: Other effects on femaleNTIS** OTS0538412
oral/rat 2800 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
BDERB* 74,243,2005
oral/rat 1750 mg/kg (6-19D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Other postnatal measures or effects
BDERB* 74,243,2005
oral/rat 18382 mg/kg (14D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTPTR* NIH-92-3343
skin/rat 15 gm/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on newborn: Other postnatal measures or effects
RTOPDW 30,169,1999
skin/rabbit 4550 mg/kg (6-18D pregnant)Reproductive: Other effects on femaleRTOPDW 30,169,1999
skin/rat 15000 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemRTOPDW 30,169,1999

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 21 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-478,1999
skin/mouse lowest published toxic dose: 57680 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB99-167553
skin/mouse lowest published toxic dose: 28840 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB99-167553
skin/mouse lowest published toxic dose: 20857 mg/kg/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
CBINA8 146,251,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 14 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
intramuscular/rat lethal dose (50 percent kill): 1500 mg/kgEVSSAV 2,289,1968
intraperitoneal/mouse lethal dose (50 percent kill): 210 mg/kgNTIS** OTS0516742
intraperitoneal/rat lethal dose (50 percent kill): 120 mg/kgEVSSAV 2,289,1968
intravenous/rat lethal dose (50 percent kill): 778 mg/kgEVSSAV 2,289,1968
oral/guinea pig lethal dose (50 percent kill): 2 gm/kg85INA8 5,197,1986
oral/mammal (species unspecified) lowest published lethal dose: 3 gm/kgNTIS** OTS0520710
oral/mouse lethal dose (50 percent kill): 3300 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
GISAAA 29(11),25,1964
oral/rabbit lethal dose (50 percent kill): 2200 mg/kgEVSSAV 2,289,1968
oral/rat lethal dose (50 percent kill): 620 µL/kgEye: Lacrimation

Behavioral: Tremor

Skin and Appendages: Other: Hair
NTIS** OTS0516797
skin/guinea pig lethal dose (50 percent kill): 11900 µL/kgNTIS** OTS0516742
skin/rabbit lethal dose (50 percent kill): 7640 µL/kgBehavioral: Ataxia

Musculoskeletal: Other changes

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0516797
subcutaneous/rat lethal dose (50 percent kill): 2200 mg/kgEVSSAV 2,289,1968

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 400 mg/m3/6H/98D- intermittentBrain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 46,2173,2008
inhalation/rat lowest published toxic concentration: 400 mg/m3/6H/98D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in erythrocyte (RBC) count
FCTOD7 46,2173,2008
inhalation/rat lowest published toxic concentration: 150 mg/m3/6H/98D- intermittentGastrointestinal: Ulceration or bleeding from stomach

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
FCTOD7 46,2173,2008
inhalation/rat lowest published toxic concentration: 150 mg/m3/6H/98D- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 46,2173,2008
inhalation/rat lowest published toxic concentration: 150 mg/m3/6H/98D- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FCTOD7 46,2173,2008
inhalation/rat lowest published toxic concentration: 15 mg/m3/6H/98D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 46,2173,2008
inhalation/rat lowest published toxic concentration: 8 mg/m3/6H/103D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 46,2173,2008
inhalation/rat lowest published toxic concentration: 8 mg/m3/6H/103D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 46,2173,2008
oral/mouse lowest published toxic dose: 4800 mg/kg/8D- intermittentLiver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* IMM-9801
oral/mouse lowest published toxic dose: 8400 mg/kg/14D- intermittentBlood: Normocytic anemia

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
NTPTR* IMM-9801
oral/mouse lowest published toxic dose: 8400 mg/kg/14D- intermittentImmunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-9801
oral/mouse lowest published toxic dose: 4200 mg/kg/14D- intermittentImmunological Including Allergic: Decreased immune responseNTPTR* IMM-9801
oral/mouse lowest published toxic dose: 30366 mg/kg/14D- continuousLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
NTPTR* NIH-92-3343
oral/mouse lowest published toxic dose: 38402 mg/kg/13W- continuousCardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTPTR* NIH-92-3343
oral/rat lowest published toxic dose: 52 gm/kg/14D- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
NTPTR* NIH-92-3343
oral/rat lowest published toxic dose: 8827 mg/kg/13W- continuousKidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia

Related to Chronic Data: Changes in testicular weight
NTPTR* NIH-92-3343
oral/rat lowest published toxic dose: 49 gm/kg/7W- continuousLiver: Other changes

Blood: Normocytic anemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 17,308,1970
oral/rat lowest published toxic dose: 2800 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** #PB2001-103718
oral/rat lowest published toxic dose: 2100 mg/kg/7D- intermittentBehavioral: Sleep

Behavioral: Tremor

Skin and Appendages: Other: Hair
NTIS** #PB2001-103718
oral/rat lowest published toxic dose: 500 mg/kg/4D- intermittentBehavioral: Fluid intakeNTIS** #PB2001-103718
oral/rat lowest published toxic dose: 1750 mg/kg/14D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightNTIS** #PB2001-103718
oral/rat lowest published toxic dose: 1400 mg/kg/7D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainBDERB* 74,243,2005
oral/rat lowest published toxic dose: 800 mg/kg/4D- intermittentBehavioral: Food intake (animal)BDERB* 74,243,2005
oral/rat lowest published toxic dose: 1000 mg/kg/4D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainBDERB* 74,243,2005
oral/rat lowest published toxic dose: 875 mg/kg/7D- intermittentBehavioral: Fluid intakeBDERB* 74,243,2005
oral/rat lowest published toxic dose: 1600 mg/kg/8D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* IMM-20303
oral/rat lowest published toxic dose: 2800 mg/kg/14D- intermittentBlood: Normocytic anemia

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
NTPTR* IMM-20303
oral/rat lowest published toxic dose: 2800 mg/kg/14D- intermittentBlood: Changes in cell count (unspecified)

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-20303
skin/mouse lowest published toxic dose: 70 mg/kg/1W- intermittentLiver: Changes in liver weightFCTOD7 42,127,2004
skin/mouse lowest published toxic dose: 910 mg/kg/13W- intermittentTumorigenic: Cells (cultured) transformedFCTOD7 42,127,2004
skin/mouse lowest published toxic dose: 280 mg/kg/1W- intermittentLiver: Other changesFCTOD7 42,127,2004
skin/mouse lowest published toxic dose: 1120 mg/kg/1W- intermittentLiver: Changes in liver weight

Tumorigenic: Cells (cultured) transformed
FCTOD7 42,127,2004
skin/mouse lowest published toxic dose: 4410 mg/kg/1W- intermittentSkin: After topical application: CorrosiveFCTOD7 42,127,2004
skin/mouse lowest published toxic dose: 1120 mg/kg/1W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOXID9 60,287,2001
skin/mouse lowest published toxic dose: 30 gm/kg/16D- intermittentLiver: Changes in liver weight

Skin: After systemic exposure: Dermatitis, other

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NIH-92-3343
skin/mouse lowest published toxic dose: 40950 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTPTR* NIH-92-3343
skin/rat lowest published toxic dose: 1008 mg/kg/16D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
NTPTR* NIH-92-3343
skin/rat lowest published toxic dose: 8125 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia
NTPTR* NIH-92-3343

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 101,136,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 101,136,2013
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 101,136,2013
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWENTOX* -,266,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWTOPADD 33,517,2005
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUREAV 566,49,2004
TOXICOLOGY REVIEWMUREAV 672,10,2009
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWMUREAV 653,99,2008
TOXICOLOGY REVIEWEMMUEG 49,9,2008
TOXICOLOGY REVIEWMUREAV 786-788,14,2015
TOXICOLOGY REVIEWREPTED 58,252,2015
TOXICOLOGY REVIEWMUREAV 795,7,2016

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 3 ppm (13 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.46 ppm (2 mg/m3);KZW 0.92 ppm (4 mg/m3), skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.46 ppm (2 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.46 ppm (2 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.46 ppm (2 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 3 ppm (15 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 1 mg/m3, inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.46 ppm (2 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 3 ppm (15 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 3 ppm (13 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 3 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.46 ppm (2 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 3 ppm (15 mg/m3);short term exposure limit 6 ppm (30 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 1 mg/m3, inhal, skin, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 2 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHANOLAMINE-air10H time-weighted average 3 ppmNIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code 24615; Number of Industries 249; Total Number of Facilities 46466; Number of Occupations 171; Total Number of Employees Exposed 828471; Total Number of Female Employees Exposed 218923
National Occupational Hazard Survey 1974Hazard Code T0517; Number of Industries 3; Total Number of Facilities 315; Number of Occupations 2; Total Number of Employees Exposed 857
National Occupational Hazard Survey 1974Hazard Code 24615; Number of Industries 147; Total Number of Facilities 18443; Number of Occupations 118; Total Number of Employees Exposed 186455

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8736;8EHQ-0293-8746
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (derm);clear evidence:mouse
NCI Carcinogenesis Studies (derm);no evidence:rat
NIOSH Analytical Method, 1994: Aminoethanol compounds II, 3509
NTP Toxicity studies, RPT# TOX-20, October 2000
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