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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-(diethylamino)-

RTECS #

KK5075000

CAS #

100-37-8

Updated

December 2015

Molecular Weight

117.22

Molecular Formula

C6H15NO

Synonyms

2-(Diethylamino)ethanol
2-Diethylaminoethanol
2-Diethylaminoethanol (ACGIH:OSHA)
2-Hydroxytriethylamine
2-N-Diethylaminoethanol
beta-Diethylaminoethanol
beta-Diethylaminoethyl alcohol
DEAE
Diaethylaminoaethanol (German)
Diethylethanolamine
N,N-Diethylethanolamine
N,N-Diethyl-N-(beta-hydroxyethyl)amine
N-Diethylaminoethanol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 mg severeUCDS** 6/11/1963
skin /rabbit 10 mg/24H open irritation testJIHTAB 26,269,1944
skin /rabbit 500 mg open irritation test mildUCDS** 6/11/1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rabbit, ocular Inhibitor Concentration Low: 5 pph/5MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 25,1425,2011
inhalation/human lowest published toxic concentration: 200 ppmGastrointestinal: Nausea or vomiting34ZIAG -,216,1969
inhalation/mouse lethal concentration (50 percent kill): 5000 mg/m3Brain and Coverings: Recordings from specific areas of CNS

Eye: Conjunctiva irritation

Behavioral: Convulsions or effect on seizure threshold
GTPZAB 14(11),52,1970
inhalation/rat Lowest published lethal concentration: 4500 mg/m3/4HBrain and Coverings: Recordings from specific areas of CNS

Eye: Conjunctiva irritation

Behavioral: Convulsions or effect on seizure threshold
GTPZAB 14(11),52,1970
intramuscular/mouse lethal dose (50 percent kill): 416 mg/kgARZNAD 9,31,1959
intraperitoneal/mouse lethal dose (50 percent kill): 192 mg/kgBehavioral: AtaxiaJPETAB 94,249,1948
intraperitoneal/rat lethal dose (50 percent kill): 1220 mg/kgTXAPA9 12,486,1968
intravenous/mouse lethal dose (50 percent kill): 188 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
ARZNAD 9,31,1959
oral/rat lethal dose (50 percent kill): 1300 mg/kgJIHTAB 26,269,1944
skin/guinea pig lethal dose (50 percent kill): 1 mL/kgJIHTAB 26,269,1944
skin/rabbit lethal dose (50 percent kill): 1260 µL/kgUCDS** 6/11/1963
subcutaneous/mouse lethal dose (50 percent kill): 650 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes
ARZNAD 9,31,1959
unreported route/mammal (species unspecified) lowest published lethal dose: 1300 mg/kg34ZIAG -,216,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 500 ppm/6H/5D- intermittentEye: Other eye effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 26,479,1965
inhalation/rat lowest published toxic concentration: 200 ppm/6H/26W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldAIHAAP 26,479,1965
inhalation/rat lowest published toxic concentration: 76 ppm/6H/14W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 18,418,1992
inhalation/rat lowest published toxic concentration: 301 ppm/6H/2W- intermittentBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 18,418,1992
oral/Dog lowest published toxic dose: 21559 mg/kg/1Y- continuousBrain and Coverings: Other degenerative changes

Behavioral: Ataxia

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
NTIS** OTS0530455-1
oral/Dog lowest published toxic dose: 4875 mg/kg/39D- intermittentBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0536945

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFCTOD7 55,596,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 ppm (50 mg/m3) (skin)DTLVS* 3,85,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (48 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (24 mg/m3);KZW 5 ppm (24 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (9.7 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (9.6 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 10 ppm (49 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 10 ppm (50 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 5 ppm (24 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (9.6 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (50 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (50 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (48 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (9.6 mg/m3), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 50 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 2 ppm (10 mg/m3);short term exposure limit 10 ppm (50 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (50 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 9.6 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 10 ppm (50 mg/m3), Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 10 ppm (50 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 10 ppm (50 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 10 ppm (50 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 10 ppm (50 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-DIETHYLAMINOETHANOL-air10H time-weighted average 10 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 24930; Number of Industries 115; Total Number of Facilities 11825; Number of Occupations 68; Total Number of Employees Exposed 106878; Total Number of Female Employees Exposed 20564
National Occupational Hazard Survey 1974Hazard Code 24930; Number of Industries 71; Total Number of Facilities 7801; Number of Occupations 39; Total Number of Employees Exposed 23770

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aminoethanol compounds I, 2007
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