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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-butoxy-, acetate

RTECS #

KJ8925000

CAS #

112-07-2

Updated

September 2013

Molecular Weight

160.24

Molecular Formula

C8H16O3

Synonyms

2-Butoxyethanol acetate
2-Butoxyethyl acetate
2-Butoxyethylester kyseliny octove (Czech)
Acetic acid, 2-butoxyethyl ester
Butyl cellosolve acetate
Butylcelosolvacetat (Czech)
Butylglycol acetate
Ektasolve EB acetate
Ethylene glycol monobutyl ether acetate
Glycol monobutyl ether acetate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,713,1986
skin /rabbit 500 mg open irritation test mildUCDS** 1/31/1966

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 3042.8 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
oral/mouse lethal dose (50 percent kill): 3200 mg/kgKODAK* 21MAY1971
oral/rat lethal dose (50 percent kill): 2400 mg/kgKidney, Ureter, and Bladder: Hematuria

Kidney, Ureter, and Bladder: Other changes in urine composition
TXAPA9 51,117,1979
skin/guinea pig lowest published lethal dose: 5 mL/kgKODAK* 21MAY1971
skin/rabbit lethal dose (50 percent kill): 1500 mg/kgKidney, Ureter, and Bladder: Hematuria

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Normocytic anemia
TXAPA9 51,117,1979

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 4060 mg/kg/2W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
ARTODN 73,229,1999

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 20 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 20 ppm (133 mg/m3), short term exposure limit 50 ppm (333 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (133 mg/m3);KZW 40 ppm (270 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 20 ppm (133 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 50 ppm (333 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 20 ppm (130 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 133 mg/m3 (20 ppm);short term exposure limit 333 mg/m3 (50 ppm), skin, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 20 ppm (130 mg/m3), short term exposure limit 50 ppm (330 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 2 ppm (13.3 mg/m3), VLE 30 ppm (199.8 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 10 ppm (66 mg/m3), skin, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 133 mg/m3, short term exposure limit 333 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 20 ppm (133 mg/m3), short term exposure limit 50 ppm (333 mg/m3), skin, NOV2011
Occupational Exposure Limit-PERUtime-weighted average 20 ppm (131 mg/m3); short term exposure limit 50 ppm, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 100 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (70 mg/m3);short term exposure limit 20 ppm (140 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (66 mg/m3), KZG-week 20 ppm (132 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 135 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 20 ppm (133 mg/m3);short term exposure limit 50 ppm (332 mg/m3), skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EGBEA-air10H time-weighted average 5 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 81350; Number of Industries 116; Total Number of Facilities 15329; Number of Occupations 70; Total Number of Employees Exposed 150893; Total Number of Female Employees Exposed 38379
National Occupational Hazard Survey 1974Hazard Code 81350; Number of Industries 50; Total Number of Facilities 4676; Number of Occupations 41; Total Number of Employees Exposed 36527

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/102527/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #83
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