Ethanol, 2-butoxy-

RTECS #

KJ8575000

CAS #

111-76-2
See: NMAM or OSHA Methods

Updated

June 2018

Molecular Weight

118.20

Molecular Formula

C₆H₁₄O₂

Synonyms

2-Butossi-etanolo (Italian)
2-Butoxy-1-ethanol
2-Butoxy-aethanol (German)
2-Butoxyethanol
2-Butoxyethanol (ACGIH:OSHA)
3-Oxa-1-heptanol
BUCS
Butoksyetylowy alkohol (Polish)
Butoxyethanol
Butyl cellosolve
Butyl cellosolve (OSHA)
Butyl oxitol
Butylcelosolv (Czech)
Butylglycol (French,German)
Dowanol EB
Ektasolve EB
Ethylene glycol monobutyl ether
Ethylene glycol n-butyl ether
Ethylene glycol, monobutyl ether
Gafcol EB
Glycol butyl ether
Glycol ether EB
Glycol monobutyl ether
Jeffersol EB
Monobutyl ether of ethylene glycol
Monobutyl glycol ether
n-Butoxyethanol
O-Butyl ethylene glycol
Poly-Solv EB

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 mg	severe	AJOPAA 29,1363,1946
eye /rabbit	100 mg/24H	moderate	85JCAE -,629,1986
skin /rabbit	500 mg open irritation test	mild	UCDS**

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA Damage	unreported route/mouse	3150 mg/kg/7D	TOXID9 66,306,2002
mutation in microorganisms	/Salmonella typhimurium	19 µmol/plate (-enzymatic activation step)	MUREAV 341,281,1995
Unscheduled DNA Synthesis	unreported route/mouse	1575 mg/kg/7D	TOXID9 66,306,2002

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	483 mg/m³/6H (6-15D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Musculoskeletal system	VCVGK* -,167,1994
inhalation/rabbit	483 mg/m³/6H (6-15D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Musculoskeletal system	VCVGK* -,167,1994
inhalation/rat	200 ppm/6H (6-15D pregnant)	Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	EVHPAZ 57,47,1984
inhalation/rat	25 ppm/6H (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	EVHPAZ 57,47,1984
inhalation/rat	12 mg/kg/4H (1-19D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	FAVUAI 21,30,1989
inhalation/rat	200 ppm/6H (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Musculoskeletal system	NTIS** OTS0571237
inhalation/rabbit	200 ppm/6H (6-18D pregnant)	Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	EVHPAZ 57,47,1984
inhalation/rabbit	100 ppm/6H (6-18D pregnant)	Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system	EVHPAZ 57,47,1984
oral/mouse	9440 mg/kg (7-14D pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	EVHPAZ 57,141,1984
oral/rat	6279 mg/kg (13W male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	NTPTR* NIH-93-3349
oral/mouse	9440 mg/kg (7-14D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	EVHPAZ 57,141,1984
oral/mouse	7 gm/kg (8-14D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	TCMUD8 7,55,1987
oral/mouse	9440 mg/kg (6-13D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	TCMUD8 7,29,1987
oral/mouse	25.2 gm/kg (7D male/7D prior to copulation/21D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB85226827
oral/mouse	47.25 gm/kg (7D male/7D prior to copulation/21D pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	NTIS** #PB85226827
oral/mouse	0.72 gm/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB85226827
oral/mouse	0.72 gm/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Hepatobiliary system	NTIS** #PB85226827
oral/mouse	198.45 gm/kg (21W prior to copulation)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB85226827
oral/rat	600 mg/kg (9-11D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	NTIS** #PB89-165849

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 250 ppm/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NTPTR* NTP-TR-484,2000
inhalation/mouse	lowest published toxic concentration: 15600 mg/kg/104W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NTIS** PB#2000-105865
inhalation/mouse	lowest published toxic concentration: 15600 mg/kg/104W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors	NTIS** PB#2000-105865
inhalation/rat	lowest published toxic concentration: 3250 mg/kg/104W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Endocrine: Adrenal cortex tumors	NTIS** PB#2000-105865
inhalation/rat	lowest published toxic concentration: 125 ppm/6H/2Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Endocrine: Tumors	NTPTR* NTP-TR-484,2000

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, neuroblastoma	Inhibitor Concentration Low: 25 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 36,153,2016
In Vitro/Human, neuroblastoma	Inhibitor Concentration Low: 1 mmol/L/24H	In Vitro Toxicity Studies: Other assays Biochemical: Metabolism (intermediary): Effect on mitochondrial function	TIVIEQ 36,153,2016
In Vitro/Human, neuroblastoma	Inhibitor Concentration Low: 10 mmol/L/24H	In Vitro Toxicity Studies: Apoptosis in vitro	TIVIEQ 36,153,2016
In Vitro/Rabbit, ocular	Inhibitor Concentration Low: 5 pph/5M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 25,1425,2011
In Vitro/Rat, embryo	Inhibitor Concentration Low: 12.5 mmol/L/48H	Reproductive: Other effects to embryo or fetus	TIVIEQ 7,777,1993
In Vitro/Rat, embryo	Inhibitor Concentration Low: 25 mmol/L/48H	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TIVIEQ 7,777,1993
In Vitro/Rat, embryo	Inhibitor Concentration Low: 12.5 mmol/L/48H	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Other developmental abnormalities	TIVIEQ 7,777,1993
inhalation/guinea pig	Lethal concentration: >633 ppm/1H		NTIS** OTS0572613
inhalation/human	lowest published toxic concentration: 195 ppm/8H	Gastrointestinal: Nausea or vomiting	AMIHAB 14,114,1956
inhalation/human	lowest published toxic concentration: 100 ppm	Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Other changes	NPIRI* 1,50,1974
inhalation/human	lowest published toxic concentration: 1500 mg/m³	Eye: Conjunctiva irritation Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,166,1984
inhalation/mouse	lethal concentration (50 percent kill): 3380 mg/m³/7H	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other hemolysis with or without anemia	VCVGK* -,166,1984
inhalation/mouse	lethal concentration (50 percent kill): 700 ppm/7H	Behavioral: Analgesia Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria	JIHTAB 25,157,1943
inhalation/rat	lethal concentration (50 percent kill): 450 ppm/4H	Behavioral: Ataxia Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXAPA9 68,405,1983
inhalation/rat	lethal concentration (50 percent kill): 2900 mg/m³/7H	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other hemolysis with or without anemia	VCVGK* -,166,1984
inhalation/rat	Lowest published lethal concentration: 1800 mg/m³/7H	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other hemolysis with or without anemia	VCVGK* -,166,1984
intraperitoneal/mammal (species unspecified)	lowest published toxic dose: 100 mg/kg	Endocrine: Change in gonadotropins	VCVGK* -,166,1984
intraperitoneal/mouse	lethal dose (50 percent kill): 536 mg/kg		SCCUR* -,2,1961
intraperitoneal/rabbit	lethal dose (50 percent kill): 220 mg/kg		85GMAT -,67,1982
intraperitoneal/rat	lethal dose (50 percent kill): 220 mg/kg		85GMAT -,67,1982
intravenous/mouse	lethal dose (50 percent kill): 1130 mg/kg		AMIHAB 14,114,1956
intravenous/rabbit	lethal dose (50 percent kill): 252 mg/kg		AMIHAB 14,114,1956
intravenous/rat	lethal dose (50 percent kill): 307 mg/kg		AMIHAB 14,114,1956
oral/guinea pig	lethal dose (50 percent kill): 1200 mg/kg	Behavioral: General anesthetic Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes	JIHTAB 23,259,1941
oral/human	lowest published lethal dose: 143 mg/kg		VCVGK* -,166,1984
oral/man	lowest published toxic dose: 132 mg/kg	Behavioral: Sleep Kidney, Ureter, and Bladder: Hematuria Nutritional and Gross Metabolic: Changes in: Metabolic acidosis	JTCTDW 41,57,2003
oral/mouse	lethal dose (50 percent kill): 1167 mg/kg	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other hemolysis with or without anemia	VCVGK* -,166,1984
oral/mouse	lethal dose (50 percent kill): 1230 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair	AMIHAB 14,114,1956
oral/rabbit	lethal dose (50 percent kill): 320 mg/kg	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other hemolysis with or without anemia	VCVGK* -,166,1984
oral/rabbit	lethal dose (50 percent kill): 300 mg/kg		YKYUA6 32,1241,1981
oral/rat	lethal dose (50 percent kill): 917 mg/kg	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other hemolysis with or without anemia	VCVGK* -,166,1984
oral/rat	lethal dose (90 percent kill): 1500 mg/kg	Kidney, Ureter, and Bladder: Hematuria Blood: Other changes	TXAPA9 225,102,2007
oral/rat	lowest published lethal dose: 1500 mg/kg	Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance	TOXID9 90,61,2006
oral/rat	lethal dose (50 percent kill): 250 mg/kg		ENTOX* -,290,2005
oral/rat	lowest published toxic dose: 500 mg/kg	Blood: Other hemolysis with or without anemia	TOXID9 44,172,2005
oral/woman	lowest published toxic dose: 600 mg/kg	Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Changes in: Metabolic acidosis	HUTODJ 7,187,1988
oral/woman	lowest published toxic dose: 7813 µL/kg	Behavioral: Coma Vascular: BP lowering not characterized in autonomic section Nutritional and Gross Metabolic: Changes in: Metabolic acidosis	HUTODJ 8,243,1989
skin/guinea pig	lethal dose (50 percent kill): 230 µL/kg		TXAPA9 7,559,1965
skin/rabbit	lethal dose (50 percent kill): 220 mg/kg		DOWCC* MSD-46
skin/rabbit	lowest published toxic dose: 0.56 mL/kg/1H	Blood: Other hemolysis with or without anemia Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,167,1984
subcutaneous/mouse	lowest published lethal dose: 500 mg/kg		JPETAB 42,355,1931
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 1500 mg/kg		GISAAA 51(5),61,1986
unreported route/mouse	lethal dose (50 percent kill): 1050 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Lung, Thorax, or Respiration: Other changes	GISAAA 41(11),7,1976
unreported route/rat	lethal dose (50 percent kill): 917 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Lung, Thorax, or Respiration: Other changes	GISAAA 41(11),7,1976
unreported route/rat	lowest published toxic dose: 250 mg/kg	Blood: Change in clotting factors	TOXID9 44,172,2005

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lowest published toxic concentration: 415 ppm/7H/12W- intermittent	Blood: Microcytosis with or without anemia Kidney, Ureter, and Bladder: Other changes in urine composition	JIHTAB 25,409,1943
inhalation/Dog	lowest published toxic concentration: 385 ppm/7H/28D- intermittent	Blood: Other changes Blood: Changes in erythrocyte (RBC) count Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHAB 14,114,1956
inhalation/Dog	lowest published toxic concentration: 2000 mg/m³/7H/12W- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	VCVGK* -,167,1994
inhalation/guinea pig	lowest published toxic concentration: 2500 mg/m³/8H/12D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,167,1994
inhalation/guinea pig	lowest published toxic concentration: 376 ppm/7H/30D- intermittent	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AMIHAB 14,114,1956
inhalation/monkey	lowest published toxic concentration: 500 mg/m³/7H/12W- intermittent	Blood: Normocytic anemia Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	VCVGK* -,167,1994
inhalation/mouse	lowest published toxic concentration: 396 ppm/7H/30D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Hematuria Blood: Other changes	AMIHAB 14,114,1956
inhalation/mouse	lowest published toxic concentration: 401 ppm/7H/90D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Hematuria Blood: Other changes	AMIHAB 14,114,1956
inhalation/rat	lowest published toxic concentration: 1540 mg/m³/7H/5W- intermittent	Blood: Changes in erythrocyte (RBC) count	JIHTAB 25,374,1943
inhalation/rat	lowest published toxic concentration: 432 ppm/7H/30D- intermittent	Kidney, Ureter, and Bladder: Hematuria Blood: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHAB 14,114,1956
inhalation/rat	lowest published toxic concentration: 245 ppm/6H/9D- intermittent	Liver: Changes in liver weight Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count	TXAPA9 68,405,1983
inhalation/rat	lowest published toxic concentration: 10 mg/m³/24H/13W- continuous	Endocrine: Hypoglycemia Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	GISAAA 41(11),7,1976
inhalation/rat	lowest published toxic concentration: 421 mg/m³/13W- intermittent	Blood: Other hemolysis with or without anemia	VCVGK* -,167,1994
inhalation/rat	lowest published toxic concentration: 516 mg/m³/30D- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,167,1994
inhalation/rat	lowest published toxic concentration: 10 mg/m³/90D- continuous	Endocrine: Hypoglycemia Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,167,1994
inhalation/rat	lowest published toxic concentration: 900 mg/m³/4H/25D- intermittent	Brain and Coverings: Increased intracranial pressure Kidney, Ureter, and Bladder: Changes primarily in glomeruli Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,167,1994
oral/mouse	lowest published toxic dose: 198.45 gm/kg/21W- continuous	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** #PB85226827
oral/mouse	lowest published toxic dose: 37.8 gm/kg/4W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #PB85226827
oral/mouse	lowest published toxic dose: 20.16 gm/kg/4W- continuous	Behavioral: Fluid intake	NTIS** #PB85226827
oral/mouse	lowest published toxic dose: 198.45 gm/kg/21W- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #PB85226827
oral/mouse	lowest published toxic dose: 198.45 gm/kg/21W- continuous	Kidney, Ureter, and Bladder: Changes in kidney weight Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #PB85226827
oral/mouse	lowest published toxic dose: 5180 mg/kg/2W- continuous	Endocrine: Changes in thymus weight	NTPTR* NIH-93-3349
oral/mouse	lowest published toxic dose: 9440 mg/kg/8D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	EVHPAZ 57,141,1984
oral/mouse	lowest published toxic dose: 5 gm/kg/10D- intermittent	Gastrointestinal: Gastritis	TXCYAC 180,257,2002
oral/mouse	lowest published toxic dose: 2250 mg/kg/7D- intermittent	Liver: Changes in liver weight Blood: Other hemolysis with or without anemia Blood: Changes in spleen	TOSCF2 70,252,2002
oral/mouse	lowest published toxic dose: 51429 mg/kg/90D- intermittent	Liver: Other changes Blood: Other changes Nutritional and Gross Metabolic: Conditioned vitamin deficiency	TOXID9 60,287,2001
oral/mouse	lowest published toxic dose: 51429 mg/kg/90D- intermittent	Biochemical: Metabolism (intermediary): Other	TOXID9 60,287,2001
oral/mouse	lowest published toxic dose: 6300 mg/kg/7D- intermittent	Liver: Other changes	TOXID9 -,333,2009
oral/mouse	lowest published toxic dose: 2250 mg/kg/7D- intermittent	Liver: Other changes Endocrine: Changes in spleen weight	TXCYAC 270,131,2010
oral/mouse	lowest published toxic dose: 4500 mg/kg/7D- intermittent	Liver: Changes in liver weight Endocrine: Changes in spleen weight Blood: Other hemolysis with or without anemia	TXCYAC 270,131,2010
oral/rat	lowest published toxic dose: 46.5 mg/kg/60D- continuous	Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,167,1994
oral/rat	lowest published toxic dose: 500 mg/kg/2D- intermittent	Blood: Other changes	ARTODN 77,465,2003
oral/rat	lowest published toxic dose: 500 mg/kg/4D- intermittent	Vascular: Thromobosis distant from injection site Blood: Other hemolysis with or without anemia	ETPAEK 58,311,2007
oral/rat	lowest published toxic dose: 3500 mg/kg/7D- intermittent	Blood: Other changes	TXAPA9 230,338,2008
oral/rat	lowest published toxic dose: 1575 mg/kg/7D- intermittent	Liver: Other changes Blood: Other hemolysis with or without anemia Blood: Changes in spleen	TOSCF2 70,252,2002
oral/rat	lowest published toxic dose: 14000 mg/kg/4W- intermittent	Endocrine: Changes in thymus weight Blood: Changes in bone marrow not included in above Related to Chronic Data: Changes in ovarian weight	VCVGK* -,166,1994
oral/rat	lowest published toxic dose: 2170 mg/kg/4W- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in erythrocyte (RBC) count	VCVGK* -,166,1994
oral/rat	lowest published toxic dose: 13290 mg/kg/6W- intermittent	Liver: Changes in liver weight Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	FAATDF 6,349,1986
oral/rat	lowest published toxic dose: 139 gm/kg/90D- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AMIHAB 14,114,1956
oral/rat	lowest published toxic dose: 9324 mg/m³/21D- continuous	Behavioral: Fluid intake Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 16,830,1991
oral/rat	lowest published toxic dose: 1500 mg/kg/12D- intermittent	Blood: Pigmented or nucleated red blood cells Blood: Other changes Blood: Changes in erythrocyte (RBC) count	TXAPA9 112,198,1992
oral/rat	lowest published toxic dose: 300 mg/kg/3D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Changes in spleen weight	NTIS** #PB89-165849
oral/rat	lowest published toxic dose: 300 mg/kg/3D- intermittent	Blood: Normocytic anemia Blood: Other hemolysis with or without anemia	NTIS** #PB89-165849
oral/rat	lowest published toxic dose: 1000 mg/kg/4D- intermittent	Cardiac: Cardiomyopathy including infarction Vascular: Thromobosis distant from injection site Blood: Changes in bone marrow not included in above	TOXID9 72,30,2003
skin/mouse	lowest published toxic dose: 6000 mg/kg/4D- continuous	Endocrine: Changes in spleen weight Blood: Changes in spleen	IJTOFN 20,383,2001
skin/mouse	lowest published toxic dose: 2000 mg/kg/4D- continuous	Immunological Including Allergic: Decrease in cellular immune response	IJTOFN 20,383,2001
skin/mouse	lowest published toxic dose: 6 gm/kg/4D- intermittent	Endocrine: Changes in spleen weight Blood: Changes in spleen Immunological Including Allergic: Decreased immune response	TOXID9 42,209,1998
skin/rabbit	lowest published toxic dose: 6.3 mL/kg/2W- continuous	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,167,1994
skin/rabbit	lowest published toxic dose: 4500 µL/kg/9D- intermittent	Liver: Changes in liver weight Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count	NTIS** OTS0516797
skin/rat	lowest published toxic dose: 17.5 mL/kg/10D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,167,1994
subcutaneous/rat	lowest published toxic dose: 2955 mg/kg/4W- intermittent	Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain	ARTODN 82,125,2008
unreported route/rat	lowest published toxic dose: 1000 mg/kg/4D- intermittent	Blood: Change in clotting factors Musculoskeletal: Other changes	TOXID9 44,172,2005
unreported route/rat	lowest published toxic dose: 500 mg/kg/4D- intermittent	Blood: Other changes Biochemical: Metabolism (intermediary): Other proteins	TOXID9 90,341,2006
unreported route/rat	lowest published toxic dose: 1000 mg/kg/4D- intermittent	Blood: Other hemolysis with or without anemia Blood: Other changes Biochemical: Metabolism (intermediary): Other proteins	TOXID9 90,341,2006
unreported route/rat	lowest published toxic dose: 750 mg/kg/3D- intermittent	Eye: Retinal changes pigmentary deposition, retinitis, other) Eye: Changes in circulation	TOXID9 72,311,2003

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 20 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review: Group 3	IMEMDT 88,400,2006
TOXICOLOGY REVIEW		FAATDF 13,747,1989
TOXICOLOGY REVIEW		MUREAV 543,201,2003
TOXICOLOGY REVIEW		EMMUEG 39,69,2002
TOXICOLOGY REVIEW		ENTOX* -,290,2005
TOXICOLOGY REVIEW		ENTOX* -,451,2005
TOXICOLOGY REVIEW		IJTOFN 24,1,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		TOPADD 33,517,2005
TOXICOLOGY REVIEW		JTEHD6 7,385,2004
TOXICOLOGY REVIEW		REPTED 25,192,2008
TOXICOLOGY REVIEW		MUREAV 566,49,2004
TOXICOLOGY REVIEW		HUTOX* -,623,1996
TOXICOLOGY REVIEW		HUTOX* -,649,1996
TOXICOLOGY REVIEW		TOLED5 180,100,2008
TOXICOLOGY REVIEW		MUREAV 751,49,2012
TOXICOLOGY REVIEW		TXAPA9 254,86,2011
TOXICOLOGY REVIEW		TOLED5 199,203,2010
TOXICOLOGY REVIEW		MUREAV 783,66,2015
TOXICOLOGY REVIEW		REPTED 58,252,2015

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,241,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 50 ppm (240 mg/m³) (skin)	DTLVS* 3,29,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 20 ppm (96.9 mg/m³), short term exposure limit 50 ppm (242 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 20 ppm (98 mg/m³);KZW 40 ppm (200 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 20 ppm (98 mg/m³), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 50 ppm (246 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 20 ppm (98 mg/m³), skin, MAY2011
Occupational Exposure Limit-EC	time-weighted average 98 mg/m³ (20 ppm);short term exposure limit 246 mg/m³ (50 ppm), skin, JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 20 ppm (98 mg/m³), short term exposure limit 50 ppm (250 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 2 ppm (9.8 mg/m³), VLE 30 ppm (147.6 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 10 ppm (49 mg/m³), skin, 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 98 mg/m³, short term exposure limit 246 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 20 ppm (100 mg/m³), short term exposure limit 50 ppm (246 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 25 ppm (120 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 26 ppm (120 mg/m³);short term exposure limit 75 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 25 ppm (121 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 20 ppm (100 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 20 ppm (97 mg/m³); short term exposure limit 50 ppm (242 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 100 mg/m³, MAC(short term exposure limit) 360 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 10 ppm (50 mg/m³);short term exposure limit 20 ppm (100 mg/m³), Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 ppm (49 mg/m³), KZG-week 20 ppm (98 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 100 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 50 ppm (240 mg/m³), Skin, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 50 ppm (240 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 25 ppm (123 mg/m³);short term exposure limit 50 ppm (246 mg/m³), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 50 ppm (240 mg/m³) (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 50 ppm (240 mg/m³) (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 50 ppm (240 mg/m³) (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 50 ppm (240 mg/m³) (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENE GLYCOL MONOBUTYL ETHER-air	10H time-weighted average 5 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 29930; Number of Industries 402; Total Number of Facilities 130413; Number of Occupations 239; Total Number of Employees Exposed 2139297; Total Number of Female Employees Exposed 585932
National Occupational Hazard Survey 1974	Hazard Code 29930; Number of Industries 398; Total Number of Facilities 141929; Number of Occupations 199; Total Number of Employees Exposed 1547951

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/102527/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);equivocal evidence:mouse,rat
NIOSH Analytical Method, 1994: Alcohols IV, 1403
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Carcinogenisis Studies (inhalation):some evidence:mouse NTPTR* NTP-TR-484,2000
NTP Toxicity studies, RPT# TOX-26, October 2000
On EPA IRIS database
OSHA ANALYTICAL METHOD #83

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health