Ethane, 1,1,2-trichloro-1,2,2-trifluoro-

RTECS #

KJ4000000

CAS #

76-13-1
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

187.37

Molecular Formula

C₂Cl₃F₃

Synonyms

1,1,2-Trichloro-1,2,2-trifluoroethane
1,1,2-Trichloro-1,2,2-trifluoroethane (ACGIH:OSHA)
1,1,2-Trichlorotrifluoroethane
1,1,2-Trifluoro-1,2,2-trichloroethane
1,1,2-Trifluorotrichloroethane
1,2,2-Trichlorotrifluoroethane
Arcton 63
Arklone P
Asahifron 113
CFC-113
Chlorofluorethane
Chlorofluorocarbon 113
Daiflon S 3
F 113
FC 113
Fluorocarbon 113
Freon 113
Freon 113, commercial grade
Freon 113, contaminated
Freon 113, specially purified
Freon 113TR-T
Freon F113
Freon TF
Freon-TF
Frigen 113
Frigen 113 TR-T
Frigen 113a
Frigen 113TR
Frigen 113TR-N
Genetron 113
Halocarbon 113
Isceon 113
Kaiser chemicals 11
Khladon 113
Ledon 113
R 113
R 113 (Halocarbon)
Racon 113
Refrigerant 113
Refrigerant R 113

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	500 mg open irritation test	mild	UCDS** 7/10/1970
skin /rabbit	500 mg/24H	mild	85JCAE -,137,1986

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rabbit	20 ppm (8-16D pregnant)	Reproductive: Other effects on female Reproductive: Effects on newborn: Physical	EPASR* #86-890000920S
oral/rabbit	5 gm/kg (8D pregnant)	Reproductive: Other effects on female Reproductive: Effects on fertility: Abortion Reproductive: Effects on embryo or fetus: Fetal death	NTIS** OTS0571230

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lethal concentration (50 percent kill): >12 pph/2H		AMPMAR 29,381,1968
inhalation/guinea pig	Lowest published lethal concentration: 4 pph/60M	Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage	TJIDAH 95,1283,1980
inhalation/human	lowest published toxic concentration: 2500 ppm/90M	Behavioral: Change in psychophysiological tests	AIHAAP 28,43,1967
inhalation/mouse	Lowest published lethal concentration: 230000 mg/m³/2H		VCVGH* -,636,1990
inhalation/mouse	lowest published toxic concentration: 393000 mg/m³/1H	Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement Behavioral: General anesthetic	VCVGH* -,636,1990
inhalation/mouse	lethal concentration (50 percent kill): 260 gm/m³/2H	Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Cyanosis	TLSMA6 75,241,1963
inhalation/rabbit	lethal concentration (50 percent kill): 59500 ppm/2H	Eye: Other eye effects Behavioral: Excitement Lung, Thorax, or Respiration: Respiratory stimulation	NTIS** OTS0520343
inhalation/rabbit	Lowest published lethal concentration: 55120 ppm/2H	Eye: Lacrimation Gastrointestinal: Changes in structure or function of salivary glands	EPASR* #86-890000904S
inhalation/rabbit	lethal concentration (50 percent kill): 59500 ppm/2H	Vascular: Regional or general arteriolar or venous dilation Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Respiratory obstruction	EPASR* #86-890000904S
inhalation/rat	Lowest published lethal concentration: 57500 ppm/4H	Behavioral: Tremor Behavioral: Excitement	EPASR* #86-890000906S
inhalation/rat	Lowest published lethal concentration: 37000 ppm/4H	Behavioral: Tremor Behavioral: Ataxia	EPASR* #86-890000902S
inhalation/rat	lethal concentration (50 percent kill): 38000 ppm/4H		EPASR* #86-890000902S
inhalation/rat	Lowest published lethal concentration: 786000 mg/m³/4H		VCVGH* -,636,1990
inhalation/rat	lethal concentration (50 percent kill): 38500 ppm/4H	Behavioral: General anesthetic Behavioral: Excitement Behavioral: Ataxia	NTIS** OTS0520341
intraperitoneal/mouse	lowest published toxic dose: 23200 mg/kg	Liver: Other changes Biochemical: Metabolism (intermediary): Other proteins	ENVRAL 45,101,1988
intravenous/mouse	lethal dose (50 percent kill): 9 gm/kg	Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Altered sleep time (including change in righting reflex) Skin: After systemic exposure: Dermatitis, other	NTIS** OTS0520355
oral/guinea pig	Lethal dose: >10 gm/kg		NTIS** OTS0520705
oral/rabbit	lowest published lethal dose: 17 gm/kg		AIHAAP 29,521,1968
oral/rat	lethal dose (50 percent kill): 43 gm/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Other changes Skin and Appendages: Other: Hair	JMCMAR 7,378,1964
oral/rat	lethal dose (50 percent kill): 43 gm/kg	Behavioral: General anesthetic	VCVGH* -,636,1990
skin/rabbit	Lethal dose: >11 gm/kg		AIHAAP 29,521,1968
unreported route/mouse	lethal dose (50 percent kill): 40 gm/kg		USXXAM #4164653

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic concentration: 70000 mg/m³/4H/16W- intermittent	Brain and Coverings: Recordings from specific areas of CNS Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	VCVGH* -,636,1990
inhalation/human	lowest published toxic concentration: 4300 mg/m³/5D- intermittent	Brain and Coverings: Recordings from specific areas of CNS	VCVGH* -,637,1990
inhalation/human	lowest published toxic concentration: 178 mg/m³/10Y- intermittent	Behavioral: Headache	VCVGH* -,637,1990
inhalation/rat	lowest published toxic concentration: 20 pph/6H/2Y- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 11,68,1988
inhalation/rat	lowest published toxic concentration: 2000 ppm/6H/2W- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	TXCYAC 18,17,1980
inhalation/rat	lowest published toxic concentration: 17500 ppm/6H/13W - intermittent	Lung, Thorax, or Respiration: Changes in lung weight	EPASR* #86-890000892S
inhalation/rat	lowest published toxic concentration: 20000 ppm/6H/13W - intermittent	Lung, Thorax, or Respiration: Fibrosis (interstitial) Lung, Thorax, or Respiration: Other changes Lung, Thorax, or Respiration: Changes in lung weight	EPASR* #86-890000892S
multiple/guinea pig	lowest published toxic concentration: 60 mL/kg/3W- intermittent	Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TJIDAH 95,1283,1980

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1000 ppm;short term exposure limit 1250 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FAZMAE 18,365,1974
TOXICOLOGY REVIEW		AIHAAP 29,521,1968
TOXICOLOGY REVIEW		ENTOX* -,384,2005
TOXICOLOGY REVIEW		HUTOX* -,577,1996

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 1000 ppm (7600 mg/m³)	DTLVS* 3,267,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1000 ppm (7670 mg/m³), short term exposure limit 1250 ppm (9590 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 500 ppm (3800 mg/m³);KZW 1000 ppm (7600 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1000 ppm (7781 mg/m³), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 1250 ppm (9729 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 500 ppm (3800 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 1000 ppm (7800 mg/m³), short term exposure limit 1300 ppm (10000 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 1000 ppm (7600 mg/m³), VLE 1250 ppm (9500 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 500 ppm (3900 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	Prohibited in Hungary, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 500 ppm (3800 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 500 ppm (3800 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 1000 ppm (7600 mg/m³), short term exposure limit 1250 ppm (9500 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 1000 ppm (1600 mg/m³);short term exposure limit 1250 ppm, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1000 ppm (7670 mg/m³), short term exposure limit 1250 ppm (9590 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 500 ppm (3800 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 1000 ppm (7665 mg/m³); short term exposure limit 1250 ppm (9581 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 5000 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 500 ppm (4000 mg/m³);short term exposure limit 750 ppm (6000 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 500 ppm (3800 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1170 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 1000 ppm (7600 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 1000 ppm (7600 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 1000 ppm (7600 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 1000 ppm (7600 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 1000 ppm (7600 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 1000 ppm (7600 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air	10H time-weighted average 1000 ppm;short term exposure limit 1250 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 74010; Number of Industries 119; Total Number of Facilities 12471; Number of Occupations 103; Total Number of Employees Exposed 250773; Total Number of Female Employees Exposed 79790
National Occupational Hazard Survey 1974	Hazard Code 74010; Number of Industries 175; Total Number of Facilities 19387; Number of Occupations 103; Total Number of Employees Exposed 282795

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1,2-Trichloro-1,2,2-trifluoroethane, 1020
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
On EPA IRIS database
OSHA ANALYTICAL METHOD #113

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health