1,2-Ethanediamine
RTECS #
KH8575000
CAS #
Updated
March 2019
Molecular Weight
60.12
Molecular Formula
C2H8N2
Synonyms
1,2-Diaminoaethan (German)
1,2-Diamino-ethaan (Dutch)
1,2-Diaminoethane (OSHA)
1,2-Diamino-ethano (Italian)
1,2-Ethylenediamine
Aethaldiamin (German)
Aethylenediamin (German)
Dimethylenediamine
Ethyleendiamine (Dutch)
Ethylendiamine
Ethylenediamine
Ethylenediamine (ACGIH:OSHA)
Ethylene-diamine (French)
NCI-C60402
1,2-Diamino-ethaan (Dutch)
1,2-Diaminoethane (OSHA)
1,2-Diamino-ethano (Italian)
1,2-Ethylenediamine
Aethaldiamin (German)
Aethylenediamin (German)
Dimethylenediamine
Ethyleendiamine (Dutch)
Ethylendiamine
Ethylenediamine
Ethylenediamine (ACGIH:OSHA)
Ethylene-diamine (French)
NCI-C60402
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 750 µg | severe | AJOPAA 29,1363,1946 |
| eye /rabbit | 750 µg/24H | severe | 85JCAE -,440,1986 |
| skin /rabbit | 450 mg open irritation test | moderate | UCDS** 12/15/1971 |
| skin /rabbit | 10 mg/24H open irritation test | severe | AMIHBC 4,119,1951 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| mutation in microorganisms | /Salmonella typhimurium | 33 µg/plate (+enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | 3200 mg/kg (6-13D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TCMUD8 7,29,1987 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, leukemia cells | Inhibitor Concentration (5 percent kill): 69.1 mg/L/30M | In Vitro Toxicity Studies: Cell counting | TIVIEQ 27,857,2013 |
| In Vitro/Human, leukemia cells | Inhibitor Concentration Low: 54.9 mg/L/30M | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,857,2013 |
| In Vitro/Human, leukemia cells | Inhibitor Concentration (25 percent kill): 271.7 mg/L/24H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 26,1150,2012 |
| In Vitro/Human, leukemia cells | Inhibitor Concentration (50 percent kill): 265.7 mg/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 26,1150,2012 |
| In Vitro/Human, lung | Inhibitor Concentration (20 percent kill): >4 mmol/L | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 30,274,2015 |
| In Vitro/Human, lymphocyte | Inhibitor Concentration (30 percent kill): 58 mg/L/45H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 29,901,2015 |
| In Vitro/Human, lymphocyte | Inhibitor Concentration (50 percent kill): 16 mg/L/45H | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,901,2015 |
| In Vitro/Human, monocyte | Inhibitor Concentration Low: 467 mg/L/2H | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,1233,2013 |
| In Vitro/Human, skin | Inhibitor Concentration (50 percent kill): >2000 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXAPA9 245,281,2010 |
| In Vitro/Human, skin | Inhibitor Concentration (50 percent kill): 99.9 µmol/L/48H | In Vitro Toxicity Studies: Other assays | TXAPA9 245,281,2010 |
| In Vitro/jrd | Inhibitor Concentration (50 percent kill): 132.8 mg/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 28,626,2014 |
| inhalation/human | lowest published toxic concentration: 200 ppm | Peripheral Nerve and Sensation: Paresthesia | AMIHBC 9,223,1954 |
| inhalation/mouse | lethal concentration (50 percent kill): 300 mg/m3 | 85GMAT -,66,1982 | |
| inhalation/rat | Lowest published lethal concentration: 4000 ppm/8H | AMIHBC 4,119,1951 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 200 mg/kg | CHTPBA 4,136,1969 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 76 mg/kg | TXAPA9 21,454,1972 | |
| intravenous/Dog | lowest published lethal dose: 100 mg/kg | HBAMAK 4,1295,1935 | |
| oral/guinea pig | lethal dose (50 percent kill): 470 mg/kg | Behavioral: Somnolence (general depressed activity) Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes | JIHTAB 23,259,1941 |
| oral/mouse | lethal dose (50 percent kill): 1 gm/kg | Behavioral: Ataxia | MTPEEI (1),38,1997 |
| oral/rat | lethal dose (50 percent kill): 1200 mg/kg | Behavioral: Ataxia | MTPEEI (1),38,1997 |
| skin/rabbit | lethal dose (50 percent kill): 730 µL/kg | AMIHBC 4,119,1951 | |
| subcutaneous/rabbit | lowest published lethal dose: 500 mg/kg | HBAMAK 4,1295,1935 | |
| subcutaneous/rat | lethal dose (50 percent kill): 300 mg/kg | 85GMAT -,66,1982 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic dose: 700 µg/m3/17W- intermittent | Brain and Coverings: Other degenerative changes Blood: Changes in spleen Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | VMDKAM 38(2),1932 |
| inhalation/rat | lowest published toxic concentration: 225 ppm/7H/30D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AMIHBC 9,223,1954 |
| oral/rabbit | lowest published toxic dose: 1400 mg/kg/14D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** #PB93-190056 |
| oral/rat | lowest published toxic dose: 540 mg/kg/6W- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Other changes in urine composition | MTPEEI (1),38,1997 |
| oral/rat | lowest published toxic dose: 3500 mg/kg/7D- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0571059 |
| oral/rat | lowest published toxic dose: 39 gm/kg/13W- intermittent | Eye: Other eye effects Blood: Hemorrhage Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0536438 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 ppm (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | JJOMDZ 15,808,1973 | |
| TOXICOLOGY REVIEW | CHHSA* 9,6,2002 | |
| TOXICOLOGY REVIEW | HUTOX* -,649,1996 | |
| TOXICOLOGY REVIEW | DERCL* 27,289,2009 | |
| TOXICOLOGY REVIEW | TXAPA9 243,225,2010 | |
| TOXICOLOGY REVIEW | FCTOD7 55,596,2013 | |
| TOXICOLOGY REVIEW | RTOPDW 55,43,2009 | |
| TOXICOLOGY REVIEW | RTOPDW 60,120,2011 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,308,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 10 ppm (25 mg/m3) | DTLVS* 3,109,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 ppm (25 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 10 ppm (25 mg/m3);KZW 40 ppm (100 mg/m3), skin, sen, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 10 ppm (25 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 10 ppm (25 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 10 ppm (25 mg/m3), short term exposure limit 20 ppm (50 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 10 ppm (25 mg/m3), VLE 15 ppm (35 mg/m3), FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 10 ppm (25 mg/m3), sen, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 10 ppm (25 mg/m3), skin, a2 sen, s2 sen, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 ppm (25 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 ppm (25 mg/m3);short term exposure limit 3 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 ppm (25 mg/m3), skin, sen, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 10 ppm (25 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 10 ppm (25 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 2 mg/m3, MAC(short term exposure limit) 6 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 2 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 10 ppm (25 mg/m3);short term exposure limit 15 ppm (35 mg/m3), Sen, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 10 ppm (25 mg/m3), KZG-week 20 ppm (50 mg/m3), sen, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 18 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 10 ppm (25 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 10 ppm (25 mg/m3), JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 10 ppm (25 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 10 ppm (25 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 10 ppm (25 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 10 ppm (25 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENEDIAMINE-air | 10H time-weighted average 10 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 32220; Number of Industries 77; Total Number of Facilities 6260; Number of Occupations 85; Total Number of Employees Exposed 113007; Total Number of Female Employees Exposed 29888 | |
| National Occupational Hazard Survey 1974 | Hazard Code 32220; Number of Industries 33; Total Number of Facilities 2126; Number of Occupations 35; Total Number of Employees Exposed 15918 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health