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Registry of Toxic Effects of Chemical Substances (RTECS)

Diisopropylamine

RTECS #

IM4025000

CAS #

108-18-9

Updated

September 2013

Molecular Weight

101.22

Molecular Formula

C6H15N

Synonyms

2-Propanamine, N-(1-methylethyl)- (9CI)
Diisopropylamine (ACGIH:OSHA)
N-(1-Methylethyl)-2-propanamine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium1 µg/plate (+/-enzymatic activation step)NUCADQ 3,129,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 2207 ppm/72MBehavioral: Coma

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands
JIHTAB 31,142,1949
inhalation/guinea pig Lowest published lethal concentration: 2207 ppm/82MBehavioral: Coma

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands
JIHTAB 31,142,1949
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 4200 mg/m3TPKVAL 14,80,1975
inhalation/mammal (species unspecified) lowest published toxic concentration: 2.4 gm/m3Eye: Conjunctiva irritationTPKVAL 7,56,1965
inhalation/mouse lethal concentration (50 percent kill): 4200 mg/m3/2H85GMAT -,54,1982
inhalation/rabbit Lowest published lethal concentration: 2207 ppm/2.5HBehavioral: Coma

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands
JIHTAB 31,142,1949
inhalation/rat lethal concentration (50 percent kill): 4800 mg/m3/2H85GMAT -,54,1982
oral/guinea pig lethal dose (50 percent kill): 2800 mg/kgGISAAA 45(3),79,1980
oral/mouse lethal dose (50 percent kill): 2120 mg/kgGISAAA 45(3),79,1980
oral/rabbit lethal dose (50 percent kill): 4700 mg/kgGISAAA 45(3),79,1980
oral/rat lethal dose (50 percent kill): 770 mg/kgUCDS** 12/15/1971
skin/rabbit lethal dose (50 percent kill): >10 gm/kgUCDS** 12,15,1971
subcutaneous/guinea pig lowest published lethal dose: 1400 mg/kgJIHTAB 31,142,1949
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 600 mg/kgTPKVAL 14,80,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 597 ppm/7H/9D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJIHTAB 31,142,1949
inhalation/mouse lowest published toxic concentration: 48300 ppb/6H/14D- intermittentOlfaction: Other olfaction effectsJJATDK 15,207,1995
inhalation/pig lowest published toxic concentration: 3.2 gm/m3/2D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,56,1965
inhalation/rabbit lowest published toxic concentration: 261 ppm/7H/54D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJIHTAB 31,142,1949
inhalation/rabbit lowest published toxic concentration: 597 ppm/7H/9D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJIHTAB 31,142,1949
inhalation/rabbit lowest published toxic concentration: 3.2 gm/m3/2D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,56,1965

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCHHSA* 9,6,2002

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 ppm (20 mg/m3) (skin)DTLVS* 3,87,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 ppm (21 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (20 mg/m3);KZW 10 ppm (40 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (21 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (20 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 5 ppm (21 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 5 ppm (20 mg/m3), Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (20 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (20 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 ppm (20 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (21 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (21 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 5 ppm (20 mg/m3);short term exposure limit 10 ppm (40 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (20 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 20 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 ppm (20 mg/m3), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 ppm (21 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 ppm (20 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 ppm (20 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 ppm (20 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 ppm (20 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIISOPROPYLAMINE-air10H time-weighted average 5 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 25850; Number of Industries 3; Total Number of Facilities 30; Number of Occupations 7; Total Number of Employees Exposed 4577; Total Number of Female Employees Exposed 745
National Occupational Hazard Survey 1974Hazard Code 25850; Number of Industries 91; Total Number of Facilities 6803; Number of Occupations 99; Total Number of Employees Exposed 91123

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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