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Registry of Toxic Effects of Chemical Substances (RTECS)

Diborane(6)

RTECS #

HQ9275000

CAS #

19287-45-7

Updated

September 2013

Molecular Weight

27.68

Molecular Formula

B2H6

Synonyms

Boroethane
Boron hydride
Diborane
Diborane (ACGIH:OSHA)
Diboron hexahydride

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium2000 ppm (+/-enzymatic activation step)MUREAV 307,335,1994
mutation in microorganisms/Salmonella typhimurium5000 ppm (-enzymatic activation step)MUREAV 307,335,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lowest published lethal concentration: 125 ppm/2HBrain and Coverings: Changes in surface EEG

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
AMIHAB 13,346,1956
inhalation/hamster Lowest published lethal concentration: 50 ppm/8HLung, Thorax, or Respiration: Acute pulmonary edemaAMIHAB 21,519,1960
inhalation/mouse lethal concentration (50 percent kill): 29 ppm/4HOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
TXAPA9 4,215,1962
inhalation/rat lethal concentration (50 percent kill): 40 ppm/4H14KTAK -,693,1964
inhalation/rat lethal concentration (50 percent kill): 60 mg/m3/4HVCVN1* -,199,1988

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 5 ppm/6H/4W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
ARTODN 69,397,1995
inhalation/rat lowest published toxic concentration: 100 ppb/6H/8W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Changes in: Na
TXAPA9 138,1977,1996

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCTOXAO 6,497,1973

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 ppm (0.1 mg/m3)DTLVS* 3,72,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 ppm (0.11 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 ppm (0.1 mg/m3);KZW 0.2 ppm (0.2 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.11 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.1 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 ppm (0.11 mg/m3), short term exposure limit 0.3 ppm (0.34 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm (0.1 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.1 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.01 ppm (0.012 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.1 ppm (0.1 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 ppm (0.1 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 ppm (0.11 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0.1 ppm (0.11 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.1 ppm (0.1 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 ppm (0.1 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 ppm (0.1 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 ppm (0.1 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 ppm (0.1 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 ppm (0.1 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 ppm (0.1 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIBORANE-air10H time-weighted average 0.1 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 23650; Number of Industries 4; Total Number of Facilities 24; Number of Occupations 12; Total Number of Employees Exposed 4616; Total Number of Female Employees Exposed 1271
National Occupational Hazard Survey 1974Hazard Code 23650; Number of Industries 2; Total Number of Facilities 24; Number of Occupations 3; Total Number of Employees Exposed 409

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH Analytical Method, 1994: Diborane, 6006
On EPA IRIS database
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