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Registry of Toxic Effects of Chemical Substances (RTECS)

1,3-Cyclopentadiene, 1,2,3,4,5,5-hexachloro-

RTECS #

GY1225000

CAS #

77-47-4

Updated

June 2017

Molecular Weight

272.75

Molecular Formula

C5Cl6

Synonyms

1,2,3,4,5,5-Hexachloro-1,3-cyclopentadiene
C-56
Graphlox
Hexachlorcyklopentadien (Czech)
Hexachloro-1,3-cyclopentadiene
Hexachlorocyclopentadiene
Hexachlorocyclopentadiene (ACGIH)
HRS 1655
NCI-C55607
Perchlorocyclopentadiene
RCRA waste number U130

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,149,1986
eye /rabbit 100 mg/5M severeVELPB* #50101-2,1976
skin /guinea pig 20 mg mildAMIHAB 11,459,1955
skin /monkey 10 mg severeAMIHAB 11,459,1955
skin /rabbit 500 mg/4H severeVELPB* #50101-2,1976
skin /rabbit 500 µL/24H severeNTIS** OTS0537036

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisother cell types/hamster27.5 µmol/LMUREAV 608,28,2006

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rabbit 975 mg/kg (6-18D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTXAPA9 53,497,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 84 mg/m3/7HVCVGH* -,551,1990
inhalation/Dog Lowest published lethal concentration: 840 mg/m3/30MVCVGH* -,551,1990
inhalation/guinea pig Lowest published lethal concentration: 139 mg/m3/3HVCVGH* -,551,1990
inhalation/guinea pig Lowest published lethal concentration: 3200 ppb/7HAMIHAB 11,459,1955
inhalation/mouse Lowest published lethal concentration: 139 mg/m3/3HVCVGH* -,551,1990
inhalation/mouse Lowest published lethal concentration: 1500 ppb/7HTXAPA9 53,497,1980
inhalation/rabbit Lowest published lethal concentration: 1500 ppb/7HTXAPA9 53,497,1980
inhalation/rabbit Lowest published lethal concentration: 139 mg/m3/3HVCVGH* -,551,1990
inhalation/rat lethal concentration (50 percent kill): 23 mg/m3/2HVCVGH* -,551,1990
inhalation/rat Lowest published lethal concentration: 139 mg/m3/3HVCVGH* -,551,1990
inhalation/rat lethal concentration (50 percent kill): 1600 ppb/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
JTEHD6 9,743,1982
oral/mouse lethal dose (50 percent kill): 505 mg/kgJAFCAU 23,967,1975
oral/rabbit lowest published lethal dose: 420 mg/kgPCOC** -,586,1966
oral/rabbit lethal dose (50 percent kill): 620 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
ENTOX* -,517,2005
oral/rat lethal dose (50 percent kill): 420 mg/kgLung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea
ENTOX* -,517,2005
oral/rat lethal dose (50 percent kill): 200 mg/kgVCVGH* -,552,1990
skin/rabbit lowest published lethal dose: 300 mg/kgVCVGH* -,552,1990
skin/rabbit lethal dose (50 percent kill): 430 mg/kg34ZIAG -,308,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 340 ppb/7H/6W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHAB 11,459,1955
inhalation/mouse lowest published toxic concentration: 150 ppb/6H/13W- intermittentLung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 6,57,1986
inhalation/mouse lowest published toxic concentration: 340 ppb/7H/6W- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 11,459,1955
inhalation/rabbit lowest published toxic concentration: 340 ppb/7H/6W- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 11,459,1955
inhalation/rat lowest published toxic concentration: 100 ppb/6H/30W- intermittentEndocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0539137
inhalation/rat lowest published toxic concentration: 500 ppb/6H/2W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTEHD6 9,743,1982
inhalation/rat lowest published toxic concentration: 400 ppb/6H/13W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in lung weight
NTPTR* NTP-TR-437,1994
oral/mouse lowest published toxic dose: 2470 mg/kg/13W- intermittentGastrointestinal: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight
JJATDK 4,75,1984
oral/rat lowest published toxic dose: 2470 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JJATDK 4,75,1984

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWENTOX* -,517,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWTOLED5 204,148,2011
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.01 ppm (0.11 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.01 ppm (0.11 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 ppm (0.1 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.01 ppm (0.11 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.01 ppm (0.1 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.01 ppm (0.1 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.01 ppm (0.1 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.01 ppm (0.1 mg/m3);short term exposure limit 0.03 ppm (0.3 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.01 ppm (0.11 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 ppm (0.1 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,01 ppm (0,11 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.01 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.01 ppm (0.1 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 1 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXACHLOROCYCLOPENTADIENE-air10H time-weighted average 0.01 ppmNIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code T0175; Number of Industries 2; Total Number of Facilities 61; Number of Occupations 14; Total Number of Employees Exposed 1427

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/166670)
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat
NIOSH Analytical Method, 1994: Hexachloro-1,3-cyclopentadiene, 2518
NTP Carcinogenesis studies (inhalation);no evidence:rat NTPTR* NTP-TR-437,1994
On EPA IRIS database
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