Cyclohexylamine

RTECS #

GX0700000

CAS #

108-91-8
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

99.20

Molecular Formula

C₆H₁₃N

Synonyms

Aminocyclohexane
Aminohexahydrobenzene
Aniline, hexahydro-
Benzenamine, hexahydro-
CHA
Cyclohexanamine
Cyclohexylamine (ACGIH)
Hexahydroaniline
Hexahydrobenzenamine

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	50 µg/24H	severe	85JCAE -,454,1986
eye /rabbit	100 µL/5M	severe	NTIS** OTS0540890
skin /human	125 mg/48H	severe	AMIHBC 5,311,1952
skin /rabbit	2 mg/24H	severe	85JCAE -,454,1986
skin /rabbit	500 µL	severe	NTIS** OTS0540890

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	leukocyte/human	10 µmol/L/5H	MUREAV 39,1,1976
Cytogenetic Analysis	intraperitoneal/rat	5 mg/kg/5D-continuous	SCIEAS 165,1139,1969
Cytogenetic Analysis	fibroblast/hamster	10 mg/L	MUREAV 39,1,1976
Cytogenetic Analysis	unreported route/domestic animal	50 mg/kg	MUREAV 26,407,1974
Cytogenetic Analysis	kidney/mammal (species unspecified)	50 mg/L/8H-continuous	FCTXAV 8,617,1970
DNA inhibition	HeLa cell/human	100 µg/L	INHEAO 9,188,1971
Dominant Lethal Test	intraperitoneal/mouse	500 mg/kg/5D- intermittent	MUREAV 14,126,1972
host-mediated assay	leukocyte/hamster	450 mg/kg/3D-continuous	MUREAV 31,5,1975
morphological transform	embryo/hamster	60 mg/L	AETODY 1,241,1980
specific locus test	intraperitoneal/mouse	200 mg/kg	PCBRD2 109,339,1982

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	300 mg/kg (1D male)	Reproductive: Effects on fertility: Other measures of fertility	FCTXAV 10,29,1972
intraperitoneal/rat	100 mg/kg (1D male)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	FCTXAV 10,29,1972
intraperitoneal/mouse	61 mg/kg (11D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TJADAB 4,141,1971
intraperitoneal/mouse	77 mg/kg (11D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	TJADAB 4,141,1971
intraperitoneal/mouse	200 mg/kg (10D pregnant)	Reproductive: Effects on fertility: Other measures of fertility	PCBRD2 109,339,1982
oral/mouse	600 mg/kg (6-11D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death	SEIJBO 11,51,1971
oral/mouse	120 mg/kg (6-11D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	SEIJBO 11,51,1971
oral/Dog	14 gm/kg (8W male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	FCTXAV 19,291,1981
oral/Dog	15750 mg/kg (9W male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	FCTXAV 19,291,1981
oral/rat	5600 mg/kg (4W male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	FCTXAV 19,291,1981
parenteral/mouse	250 mg/kg (5D male)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	AMESES 1,33,1970
unreported route/rat	5 mg/kg (1D male)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	AMESES 1,25,1970

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, skin	Inhibitor Concentration Low: 0.08 mL/well/3M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 28,616,2014
inhalation/guinea pig	Lowest published lethal concentration: 1200 ppm/7H	Lung, Thorax, or Respiration: Other changes	IMSUAI 19,317,1950
inhalation/mouse	lethal concentration (50 percent kill): 1070 mg/m³	Behavioral: Excitement Behavioral: Muscle contraction or spasticity	GTPZAB 7(11),51,1963
inhalation/rabbit	Lowest published lethal concentration: 150 ppm/7H		IMSUAI 19,317,1950
inhalation/rat	lethal concentration (50 percent kill): 7500 mg/m³	Behavioral: Excitement Behavioral: Muscle contraction or spasticity	GTPZAB 7(11),51,1963
intraperitoneal/mammal (species unspecified)	lethal dose (50 percent kill): 200 mg/kg	Brain and Coverings: Other degenerative changes Vascular: Shock Liver: Other changes	AMIHBC 5,311,1952
intraperitoneal/mouse	lethal dose (50 percent kill): 129 mg/kg		PCJOAU 22,469,1988
intraperitoneal/rat	lethal dose (50 percent kill): 300 mg/kg	Eye: Mydriasis (pupilliary dilation) Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	NYKZAU 65(1),53S,1969
intravenous/Dog	lethal dose (50 percent kill): 200 mg/kg	Behavioral: Convulsions or effect on seizure threshold	NYKZAU 65(1),53S,1969
intravenous/mouse	lethal dose (50 percent kill): 200 mg/kg		IPSTB3 3,93,1976
oral/mouse	lethal dose (50 percent kill): 224 mg/kg		85GMAT -,41,1982
oral/rat	lethal dose (50 percent kill): 11 mg/kg	Behavioral: Food intake (animal) Lung, Thorax, or Respiration: Pulmonary emboli Gastrointestinal: Other changes	NTIS** OTS0534836
parenteral/rabbit	lowest published lethal dose: 500 mg/kg	Behavioral: Convulsions or effect on seizure threshold	IECHAD 29,1247,1937
skin/rabbit	lethal dose (50 percent kill): 320 µL/kg		AIHAAP 30,470,1969
subcutaneous/mouse	lethal dose (50 percent kill): 1150 mg/kg		VOONAW 4,659,1958
unreported route/mouse	lethal dose (50 percent kill): 770 mg/kg		TXAPA9 14,654,1969

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 700 mg/m³/2H/9W- intermittent	Cardiac: Changes in heart weight Kidney, Ureter, and Bladder: Changes in bladder weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	GTPZAB 7(11),51,1963
inhalation/rat	lowest published toxic concentration: 100 mg/m³/4H/22W- intermittent	Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in cell count (unspecified) Nutritional and Gross Metabolic: Other changes	GTPZAB 7(11),51,1963
oral/rat	lowest published toxic dose: 1200 mg/kg/3D- continuous	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	EXMPA6 52,155,1990
oral/rat	lowest published toxic dose: 2800 mg/kg/1W- continuous	Related to Chronic Data: Changes in testicular weight	EXMPA6 52,155,1990
oral/rat	lowest published toxic dose: 8400 mg/kg/3W- continuous	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	EXMPA6 52,155,1990
oral/rat	lowest published toxic dose: 35700 mg/kg/1Y- continuous	Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VOONAW 4,659,1958

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 10 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMSUDL 7,178,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Animal NO EVIDENCE	IMEMDT 22,55,1980
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMSUDL 22,55,1980
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMSUDL 7,178,1987
TOXICOLOGY REVIEW		MUREAV 39,1,1976
TOXICOLOGY REVIEW		NBREV* 17,313,1993
TOXICOLOGY REVIEW		FCTOD7 55,596,2013
TOXICOLOGY REVIEW		RTOPDW 55,43,2009

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 ppm (41 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 10 ppm (40 mg/m³);KZW 10 ppm (40 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 10 ppm (42 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 10 ppm (40 mg/m³), skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 1 ppm (4.1 mg/m³), short term exposure limit 10 ppm (41 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 10 ppm (40 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 2 ppm (8.2 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 40 mg/m³, short term exposure limit 40 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 10 ppm (40 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 10 ppm (40 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 ppm (40 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 ppm (41 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 10 ppm (41 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	time-weighted average 40 mg/m³, short term exposure limit 80 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 1 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 5 ppm (20 mg/m³);short term exposure limit 10 ppm (40 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 2 ppm (8.2 mg/m³), KZG-week 4 ppm (16.4 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 5 mg/m³, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 10 ppm (41 mg/m³), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXYLAMINE-air	10H time-weighted average 10 ppm	NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983	Hazard Code 84526; Number of Industries 83; Total Number of Facilities 4729; Number of Occupations 47; Total Number of Employees Exposed 64346; Total Number of Female Employees Exposed 2914
National Occupational Hazard Survey 1974	Hazard Code 84526; Number of Industries 63; Total Number of Facilities 3468; Number of Occupations 25; Total Number of Employees Exposed 9450

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Cytogenetics-male germ cell
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health