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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclohexane, methyl-

RTECS #

GV6125000

CAS #

108-87-2

Updated

September 2013

Molecular Weight

98.21

Molecular Formula

C7H14

Synonyms

Cyclohexylmethane
Hexahydrotoluene
Methylcyclohexane
Methylcyclohexane (ACGIH:OSHA)
Metylocykloheksan (Polish)
Sextone B
Toluene hexahydride
Toluene, hexahydro-

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL/24H mildNTIS** OTS0556748
skin /rabbit 500 µL/24H mildNTIS** OTS0556749

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (16 percent kill): 35000 mg/m3/2HVCVGH* -,84,1990
inhalation/mouse lethal concentration (50 percent kill): 36900 mg/m3/2HVCVGH* -,84,1990
inhalation/mouse lethal concentration (84 percent kill): 47000 mg/m3/2HVCVGH* -,84,1990
inhalation/rabbit Lowest published lethal concentration: 60000 mg/m3/70MEye: Conjunctiva irritation

Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold
VCVGH* -,84,1990
inhalation/rabbit lethal concentration (50 percent kill): 15227 ppm/1HBehavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
JIHTAB 25,323,1943
inhalation/rat Lowest published lethal concentration: 82 gm/m3/1HBehavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
NTIS** OTS0556685
oral/mouse lethal dose (16 percent kill): 1.28 gm/kgVCVGH* -,85,1990
oral/mouse lethal dose (50 percent kill): 1.2 gm/kgVCVGH* -,85,1990
oral/mouse lethal dose (84 percent kill): 3.4 gm/kgVCVGH* -,85,1990
oral/rabbit lowest published lethal dose: 4 gm/kgGastrointestinal: Hypermotility, diarrheaJIHTAB 25,199,1943
oral/rat lethal dose (50 percent kill): >3200 mg/kgNTIS** OTS0556685
skin/rabbit Lethal dose: >86700 mg/kgJIHTAB 25,199,1943

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lowest published toxic concentration: 10054 ppm/6H/2W- intermittentEye: Conjunctiva irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 25,323,1943
inhalation/rat lowest published toxic concentration: 11 gm/m3/6H/5D- intermittentBehavioral: General anestheticNTIS** OTS0556685

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 400 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 500 ppm (2000 mg/m3)DTLVS* 3,162,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 400 ppm (1610 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 400 ppm (1600 mg/m3);KZW 1600 ppm (6400 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 400 ppm (1633 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 200 ppm (805 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 400 ppm (1600 mg/m3), short term exposure limit 500 ppm (2000 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 400 ppm (1600 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 200 ppm (810 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 200 ppm (805 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 400 ppm (1600 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 400 ppm (1600 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 400 ppm (1600 mg/m3);short term exposure limit 500 ppm (2000 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 400 ppm (1610 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 400 ppm (1606 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 500 mg/m3, MAC(short term exposure limit) 2000 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 50 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 400 ppm (1600 mg/m3), KZG-week 800 ppm (3200 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1600 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 500 ppm (2000 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 500 ppm (2000 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 500 ppm (2000 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 500 ppm (2000 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 500 ppm (2000 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 500 ppm (2000 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLCYCLOHEXANE-air10H time-weighted average 400 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 47030; Number of Industries 12; Total Number of Facilities 1175; Number of Occupations 11; Total Number of Employees Exposed 10076; Total Number of Female Employees Exposed 14
National Occupational Hazard Survey 1974Hazard Code 47030; Number of Industries 11; Total Number of Facilities 1733; Number of Occupations 9; Total Number of Employees Exposed 6292

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
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