Crotonaldehyde

RTECS #
GP9499000
CAS #
4170-30-3
See: NMAM or OSHA Methods
Updated
October 2015
Molecular Weight
70.10
Molecular Formula
C4H6O
Synonyms
1-Formylpropene
2-Butenal
2-Butenal (9CI)
2-Butenaldehyde
beta-Methylacrolein
Crotonal
Crotonaldehyde (ACGIH:OSHA)
Crotonic aldehyde
Krotonaldehyd (Czech)
Methylpropenal
RCRA waste number U053

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster1600 µg/LEMMUEG 10(Suppl 10),1,1987
DNA adductlymphocyte/mammal (species unspecified)21500 mg/L/16HCNREA8 44,990,1984
DNA adductfibroblast/human100 µmol/LCRNGDP 12,1483,1991
DNA adductother cell types/cattle0.4 mmol/plate/96HCRTOEC 14,423,2001
heritable translocation testoral/Drosophila melanogaster25 mmol/L/48HFCTOD7 53,221,2013
heritable translocation testparenteral/Drosophila melanogaster3500 ppmENMUDM 7,677,1985
micronucleus testovary/hamster66.9 µmol/L/3H (+enzymatic activation step)MUREAV 751,1,2013
micronucleus testovary/hamster22.3 µmol/L/24H (-enzymatic activation step)MUREAV 630,1,2007
mutation in microorganisms/Saccharomyes cerevisiae85.2 mg/L/16HMUTAEX 20,105,2004
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)EMMUEG 14,146,1989
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms/Escherichia coli75 nmol/plateMUREAV 516,81,2002
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster3500 ppmENMUDM 7,677,1985
sister chromatid exchangeovary/hamster500 µg/LEMMUEG 10(Suppl 10),1,1987
specific locus testother cell types/mouse25 µmol/L/4H (-enzymatic activation step)MUREAV 726,98,2011

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 2664 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
CNREA8 46,1285,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, lung Inhibitor Concentration Low: 150 µmol/L/3HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 195,90,2010
In Vitro/Human, lung Inhibitor Concentration Low: 70 µmol/L/9HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 195,90,2010
In Vitro/Human, lung Inhibitor Concentration Low: 10 µmol/L/3HIn Vitro Toxicity Studies: Other assaysTOLED5 195,90,2010
In Vitro/Human, lung Inhibitor Concentration Low: 70 µmol/L/3HIn Vitro Toxicity Studies: Apoptosis in vitroTOLED5 195,90,2010
inhalation/human lowest published toxic concentration: 25 mg/m3Olfaction: Other olfaction effectsVCVGK* -,390,1984
inhalation/human lowest published toxic concentration: 40 mg/m3/10SEye: Conjunctiva irritationVCVGK* -,390,1984
inhalation/human lowest published toxic concentration: 8 mg/m3Eye: Conjunctiva irritationVCVGK* -,390,1984
inhalation/mouse lethal concentration (50 percent kill): 580 mg/m3/2HGTPZAB 26(8),53,1982
inhalation/rat lethal concentration (50 percent kill): 200 mg/m3/2HGTPZAB 26(8),53,1982
inhalation/rat lethal concentration (50 percent kill): 9600 mg/m3/5MVCVGK* -,390,1984
inhalation/rat lethal concentration (50 percent kill): 4800 mg/m3/10MVCVGK* -,390,1984
inhalation/rat lethal concentration (50 percent kill): 2400 mg/m3/15MVCVGK* -,390,1984
inhalation/rat lethal concentration (50 percent kill): 1700 mg/m3/30MVCVGK* -,390,1984
inhalation/rat lethal concentration (50 percent kill): 1100 mg/m3/60MVCVGK* -,390,1984
inhalation/rat lethal concentration (50 percent kill): 300 mg/m3/4HVCVGK* -,390,1984
inhalation/rat lowest published toxic concentration: 87 mg/kg/4HCardiac: Other changes

Blood: Other changes
TOLED5 135,S143,2002
inhalation/rat lowest published toxic concentration: 5 mg/m3/4HVascular: Other changes

Lung, Thorax, or Respiration: Other changes
TOVEFN (6),36,1998
intravenous/cat lowest published lethal dose: 30 mg/kgBlood: Other changesAPTOA6 8,275,1952
oral/mouse lethal dose (50 percent kill): 104 mg/kgGTPZAB 26(8),53,1982
oral/rat lethal dose (50 percent kill): 80 mg/kgCardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Body temperature decrease
GISAAA 62(3),3,1997
skin/guinea pig lethal dose (50 percent kill): 30 µL/kgJIHTAB 26,269,1944
skin/rabbit lethal dose (50 percent kill): 380 µL/kgUCDS** 4/21/1967

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 20 mg/m3/7H/8W- intermittentLiver: Other changes

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other proteins
GTPZAB 18(6),55,1974
intratracheal/rat lowest published toxic dose: 5 mg/m3/13W- intermittentLung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,390,1994

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 0.3 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 63,373,1995
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 63,373,1995
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 63,373,1995
TOXICOLOGY REVIEWMUREAV 544,115,2003
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUTAEX 19,169,2004
TOXICOLOGY REVIEWMUREAV 659,56,2008
TOXICOLOGY REVIEWMUREAV 659,68,2008
TOXICOLOGY REVIEWMUREAV 690,3,2010
TOXICOLOGY REVIEWMUREAV 711,13,2011
TOXICOLOGY REVIEWEMMUEG 55,77,2014

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 2 ppm (6 mg/m3)DTLVS* 3,62,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (5.7 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 0.34 ppm (1 mg/m3);KZW 1.36 ppm (4 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.3 ppm (0.87 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (6 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 ppm (0.29 mg/m3), short term exposure limit 0.3 ppm (0.87 mg/m3), NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (6 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 2 ppm (6 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 2 ppm (6 mg/m3);short term exposure limit 6 ppm (18 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (5.7 mg/m3), skin, JAN2002
Occupational Exposure Limit-POLANDtime-weighted average 6 mg/m3, short term exposure limit 12 mg/m3, JAN1999
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 2 ppm (6 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 2 ppm (6 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 2 ppm (6 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 2 ppm (6 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 2 ppm (6 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X6304; Number of Industries 2; Total Number of Facilities 6; Number of Occupations 2; Total Number of Employees Exposed 387; Total Number of Female Employees Exposed 17

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Crotonaldehyde, 3516
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
Page last reviewed: November 16, 2018