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Registry of Toxic Effects of Chemical Substances (RTECS)

m-Cresol, 4,4'-thiobis(6-tert-butyl-

RTECS #

GP3150000

CAS #

96-69-5

Updated

September 2013

Molecular Weight

358.58

Molecular Formula

C22H30O2S

Synonyms

1,1'-Thiobis(2-methyl-4-hydroxy-5-tert-butylbenzene)
4,4'-Thiobis
4,4'-Thiobis(2-(1,1-dimethylethyl)-5-methylphenol)
4,4'-Thiobis(2-tert-butyl-5-methylphenol)
4,4'-Thiobis(3-methyl-6-tert-butylphenol)
4,4'-Thiobis(6-tert-butyl-3-methylphenol)
4,4'-Thiobis(6-tert-butyl-m-cresol)
4,4'-Thiobis(6-tert-butyl-m-cresol) (ACGIH,OSHA)
Antage Crystal
Antioxidant AO
Antioxidant TMB 6
AO 4
Bis(3-tert-butyl-4-hydroxy-6-methylphenyl) sulfide
Bis(4-hydroxy-5-tert-butyl-2-methylphenyl) sulfide
Disperse MB-61
Nocrac 300
Nonflex BPS
Phenol, 4,4'-thiobis(2-(1,1-dimethylethyl)-5-methyl- (9CI)
Santonox
Santonox BM
Santonox R
Santowhite crystals
Santox
Sumilizer WX
Sumilizer WX-R
Thioalkofen BM 4
Thioalkofen BMCH
Thioalkofen MBCH
Thioalkophene BM-4
USAF B-15
Yoshinox S
Yoshinox SR

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 5508.3 mg/kg (61D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
ARTODN 80,225,2006
oral/mouse 25803 mg/kg (61D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
ARTODN 80,225,2006
oral/rat 11742.5 mg/kg (61D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
ARTODN 80,225,2006
oral/rabbit 26 mg/kg (6-18D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
HPV260 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 50 mg/kgNTIS** AD277-689
oral/rabbit lethal dose (50 percent kill): 3200 mg/kgIPSTB3 3,93,1976
oral/rat lethal dose (50 percent kill): 4150 mg/kgBehavioral: Food intake (animal)

Gastrointestinal: Gastritis

Liver: Other changes
HPV260 -,-,2001
oral/rat lethal dose (50 percent kill): 2345 mg/kgIPSTB3 3,93,1976
skin/rabbit lethal dose (50 percent kill): >5010 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
HPV260 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 1400 mg/kg/14D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FAATDF 10,691,1988
oral/mouse lowest published toxic dose: 5915 mg/kg/13W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight
NTPTR* NTP-TR-435,1994
oral/mouse lowest published toxic dose: 5508.3 mg/kg/61D- intermittentRelated to Chronic Data: Changes in testicular weightARTODN 80,225,2006
oral/mouse lowest published toxic dose: 10980 mg/kg/61D- intermittentEndocrine: AndrogenicARTODN 80,225,2006
oral/mouse lowest published toxic dose: 25803 mg/kg/61D- intermittentLiver: Changes in liver weight

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
ARTODN 80,225,2006
oral/mouse lowest published toxic dose: 18239 mg/kg/61D- intermittentNutritional and Gross Metabolic: Body temperature decrease

Related to Chronic Data: Changes in uterine weight
ARTODN 80,225,2006
oral/mouse lowest published toxic dose: 2730 mg/kg/2Y- intermittentLiver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
HPV260 -,-,2001
oral/mouse lowest published toxic dose: 10920 mg/kg/2Y- intermittentLiver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count
HPV260 -,-,2001
oral/mouse lowest published toxic dose: 10920 mg/kg/13W- intermittentBlood: Changes in erythrocyte (RBC) countHPV260 -,-,2001
oral/mouse lowest published toxic dose: 27300 mg/kg/13W- intermittentLiver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
HPV260 -,-,2001
oral/mouse lowest published toxic dose: 4500 mg/kg/15D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV260 -,-,2001
oral/mouse lowest published toxic dose: 9000 mg/kg/15D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV260 -,-,2001
oral/rat lowest published toxic dose: 36500 mg/kg/2Y- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in erythrocyte (RBC) count
HPV260 -,-,2001
oral/rat lowest published toxic dose: 3750 mg/kg/15D- intermittentGastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV260 -,-,2001
oral/rat lowest published toxic dose: 7500 mg/kg/15D- intermittentGastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV260 -,-,2001
oral/rat lowest published toxic dose: 4550 mg/kg/13W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Other changes
HPV260 -,-,2001
oral/rat lowest published toxic dose: 5475 mg/kg/15D- continuousGastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in leukocyte (WBC) count
NTPTR* NTP-TR-435,1994
oral/rat lowest published toxic dose: 15015 mg/kg/13W- continuousLiver: Changes in liver weight

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
NTPTR* NTP-TR-435,1994
oral/rat lowest published toxic dose: 11742.5 mg/kg/61D- intermittentBlood: Changes in spleen

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
ARTODN 80,225,2006
subcutaneous/mouse lowest published toxic dose: 150 mg/kg/3D- intermittentRelated to Chronic Data: Changes in uterine weightARTODN 80,225,2006
subcutaneous/mouse lowest published toxic dose: 240 mg/kg/4D- intermittentRelated to Chronic Data: Changes in uterine weightARTODN 80,225,2006

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg/m3 (inhal)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWTOPADD 33,517,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 mg/m3, MAY2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 10 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL), dust-airtime-weighted average 10 mg/m3NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL)-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84755; Number of Industries 10; Total Number of Facilities 1286; Number of Occupations 11; Total Number of Employees Exposed 12349; Total Number of Female Employees Exposed 2177
National Occupational Hazard Survey 1974Hazard Code 84755; Number of Industries 51; Total Number of Facilities 4402; Number of Occupations 47; Total Number of Employees Exposed 36695

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9277;8EHQ-0892-9283
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat
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