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Registry of Toxic Effects of Chemical Substances (RTECS)

Copper oxide

RTECS #

GL7900000

CAS #

1317-38-0

Updated

June 2017

Molecular Weight

79.54

Molecular Formula

CuO

Synonyms

Black copper oxide
C.I. 77403
C.I. Pigment Black 15
Copper Brown
Copper monooxide
Copper monoxide
Copper(2+) oxide
Copper(II) oxide
Cupric oxide

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelung/human20 µg/disk/4HTOLED5 188,112,2009

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, ovary Inhibitor Concentration Low: 27 ppm/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 197,169,2010
In Vitro/Hamster, ovary Inhibitor Concentration Low: 4.5 ppm/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 197,169,2010
In Vitro/Human, HeLa cell Inhibitor Concentration Low: 4.5 ppm/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 197,169,2010
In Vitro/Human, HeLa cell Inhibitor Concentration Low: 4.5 ppm/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 197,169,2010
In Vitro/ppfInhibitor Concentration Low: 20 µg/well/2HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
TIVIEQ 27,1287,2013
inhalation/guinea pig lowest published toxic concentration: 1.6 mg/m3Lung, Thorax, or Respiration: Other changesHBTME* -,529,2007
intraperitoneal/mouse lethal dose (50 percent kill): 273 mg/kgVCVN1* -,67,1998
intraperitoneal/mouse lowest published toxic dose: 45.4 mg/kgBehavioral: Excitement

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN1* -,67,1998
intratracheal/rat lethal dose (50 percent kill): 250 mg/kgVCVN1* -,68,1998
intratracheal/rat lowest published lethal dose: 278 mg/kgTPKVAL 11,47,1969
intratracheal/rat lowest published toxic dose: 100 µg/kgLung, Thorax, or Respiration: SputumHBTME* -,529,2007
oral/rat lethal dose (50 percent kill): 470 mg/kgVCVN1* -,67,1998

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/woman lowest published toxic dose: 0.7 mg/kg/7D- continuousGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
EVHPAZ 109,949,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWHUTOX* -,661,1996
TOXICOLOGY REVIEWMUREAV 727,72,2011
TOXICOLOGY REVIEWMUTAEX 32,203,2017

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,305,1998
Occupational Exposure Limit-FINLANDtime-weighted average 1 mg(Cu)/m3, NOV2011
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Cu)/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg(Cu)/m3, short term exposure limit 4 mg(Cu)/m3, SEP2000
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg(Cu)/m3;time-weighted average 0.2 mg(Cu)/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Cu)/m3, KZG-week 0.2 mg(Cu)/m3, inhal, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81787; Number of Industries 16; Total Number of Facilities 1104; Number of Occupations 33; Total Number of Employees Exposed 17248; Total Number of Female Employees Exposed 4024
National Occupational Hazard Survey 1974Hazard Code 81787; Number of Industries 15; Total Number of Facilities 378; Number of Occupations 27; Total Number of Employees Exposed 13362

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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