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Registry of Toxic Effects of Chemical Substances (RTECS)

Cellulose

RTECS #

FJ5691460

CAS #

9004-34-6; 9006-02-4; 39394-43-9; 58968-67-5; 61991-21-7; 61991-22-8; 84503-75-3; 99331-82-5

Updated

June 2017

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

Abicel
alpha-Cellulose
Arbocel
Arbocel BC 200
Arbocell B 600/30
Avicel
Avicel 101
Avicel 102
Avicel CL 611
Avicel PH 101
Avicel PH 105
beta-Amylose
Cellex MX
Cellulose (ACGIH:OSHA)
Cellulose 248
Cellulose crystalline
Celufi
CEPO
Cepo CFM
CEPO S 20
CEPO S 40
Chromedia CC 31
Chromedia CF 11
Cupricellulose
Elcema F 150
Elcema G 250
Elcema P 050
Elcema P 100
Fresenius D 6
Heweten 10
Hydroxycellulose
Kingcot
LA 01
Microcrystalline cellulose
MN-Cellulose
Onozuka P 500
Pyrocellulose
Rayophane
Rayweb Q
Rexcel
Sigmacell
Solka-fil
Solka-floc
Solka-floc BW
Solka-floc BW 100
Solka-floc BW 20
Solka-floc BW 200
Solka-floc BW 2030
Spartose OM-22
Sulfite cellulose
Tomofan
Tunicin
Whatman CC-31

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >5800 mg/m3/4HTOLED5 (Suppl),243,1992
intraperitoneal/rat lethal dose (50 percent kill): >31600 mg/kgFAONAU 50A,83,1972
oral/rat lethal dose (50 percent kill): >5 gm/kgTOLED5 (Suppl),243,1992
oral/rat lowest published toxic dose: 120 gm/kgGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
EPASR* #86940001000,1994
skin/rabbit lethal dose (50 percent kill): >2 gm/kgTOLED5 (Suppl),243,1992

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 420 gm/kg/4W- continuousGastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AJPHAP 188,550,1957
oral/rat lowest published toxic dose: 159 gm/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 90,346,2006
oral/rat lowest published toxic dose: 56000 mg/kg/8W- intermittentBlood: Thrombocytopenia

Blood: Other changes

Blood: Changes in other cell count (unspecified)
TOVEFN (4),34,2007
oral/rat lowest published toxic dose: 56000 mg/kg/8W- intermittentBlood: Thrombocytopenia

Blood: Changes in other cell count (unspecified)
TOVEFN (4),34,2007
oral/rat lowest published toxic dose: 112000 mg/kg/8W- intermittentBlood: Other changesTOVEFN (4),34,2007
oral/rat lowest published toxic dose: 11200 mg/kg/8W- intermittentBlood: Change in clotting factorsTOVEFN (4),34,2007

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFCTOD7 91,42,2016

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3 (inspirable dust), JAN2002
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 3 mg/m3, resp, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3 (inhal. dust), OCT2007
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 4 mg/m3 (resp. dust), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CELLULOSE, respirable fraction-air10H time-weighted average 5 mg/m3NIOSH* DHHS #95-121,1995
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CELLULOSE, total dust-air10H time-weighted average 10 mg/m3NIOSH* DHHS #95-121,1995

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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