Carbamoyl chloride, dimethyl-

RTECS #

FD4200000

CAS #

79-44-7
See: NMAM or OSHA Methods

Updated

March 2018

Molecular Weight

107.55

Molecular Formula

C₃H₆ClNO

Synonyms

(Dimethylamino)carbonyl chloride
Carbamic acid, dimethyl- (9CI)
Carbamyl chloride, N,N-dimethyl-
Chlorid kyseliny dimethylkarbaminove (Czech)
Chloroformic acid dimethylamide
Dimethyl carbamoyl chloride
Dimethyl carbamoyl chloride (ACGIH)
Dimethylamid kyseliny chlormravenci (Czech)
Dimethylcarbamic acid chloride
Dimethylcarbamic chloride
Dimethylcarbamidoyl chloride
Dimethylcarbamoyl chloride
Dimethylcarbamyl chloride
Dimethylchloroformamide
Dimethylkarbamoylchlorid (Czech)
N,N-Dimethylaminocarbonyl chloride
N,N-Dimethylcarbamic acid chloride
N,N-Dimethylcarbamidoyl chloride
N,N-Dimethylcarbamoyl chloride
N,N-Dimethylcarbamyl chloride
RCRA waste number U097
TL 389

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	ovary/hamster	33 µL/L	PMRSDJ 1,551,1981
DNA repair	/Escherichia coli	10 mg/L	JJIND8 62,873,1979
DNA repair	/Saccharomyes cerevisiae	136 µmol/L	CNJGA8 24,771,1982
DNA repair	/Schizosaccharomyces pombe	136 µmol/L	CNJGA8 24,771,1982
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	2 gm/L	PMRSDJ 1,481,1981
host-mediated assay	Salmonella typhimurium/mouse	1 gm/kg	JJIND8 62,911,1979
micronucleus test	intraperitoneal/mouse	1400 µg/kg	PMRSDJ 1,698,1981
morphological transform	kidney/hamster	80 µg/L	BJCAAI 37,873,1978
morphological transform	embryo/hamster	100 µg/L	IJCNAW 19,642,1977
mutation in mammalian somatic cells	lymphocyte/mouse	1200 mg/L	PMRSDJ 1,580,1981
mutation in microorganisms	lymphocyte/mouse	187 mg/L (+enzymatic activation step)	MUREAV 97,49,1982
mutation in microorganisms	/Saccharomyes cerevisiae	89 mg/L (+enzymatic activation step)	PMRSDJ 1,414,1981
mutation in microorganisms	/Schizosaccharomyces pombe	2 mg/L (+/-enzymatic activation step)	PMRSDJ 1,424,1981
mutation in microorganisms	/Salmonella typhimurium	33 µg/plate (+enzymatic activation step)	ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms	/Salmonella typhimurium	300 ng/plate (-enzymatic activation step)	ENMUDM 6(Suppl 2),1,1984
mutation in microorganisms	/Escherichia coli	100 µg/plate (+/-enzymatic activation step)	ENMUDM 6(Suppl 2),1,1984
other mutation test systems	/Escherichia coli	540 pmol/tube	MUREAV 147,79,1985
phage inhibition capacity	/Escherichia coli	500 µL/L	PMRSDJ 1,224,1981
sex chromosome loss and nondisjunction	parenteral/Drosophila melanogaster	10 pph	ENMUDM 7,349,1985
sex chromosome loss and nondisjunction	/Saccharomyes cerevisiae	100 mg/L	PMRSDJ 1,468,1981
sister chromatid exchange	ovary/hamster	100 µmol/L	MUREAV 118,103,1983
sister chromatid exchange	lung/hamster	100 µmol/L	MUREAV 118,103,1983
Unscheduled DNA Synthesis	fibroblast/human	32 µg/L	PMRSDJ 1,528,1981

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
inhalation/hamster	lowest published toxic concentration: 1 ppm/6H/89W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JEPTDQ 4(1),107,1980
inhalation/hamster	toxic concentration: 1 ppm/6H/2Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Olfaction: Tumors	JEPTDQ 4(1),107,1980
inhalation/rat	toxic concentration: 1 ppm/6H/6W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors	PAACA3 21,106,1980
inhalation/rat	toxic concentration: 1 ppm	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Olfaction: Tumors	OHSLAM 6,5,1976
inhalation/rat	lowest published toxic concentration: 1 ppm/6H/6W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors	CALEDQ 33,175,1986
intraperitoneal/mouse	lowest published toxic dose: 2560 mg/kg/64W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Tumors at site of application	JNCIAM 53,695,1974
skin/mouse	lowest published toxic dose: 17280 mg/kg/72W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application	JACTDZ 6(4),479,1987
skin/mouse	toxic dose: 13 gm/kg/55W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors	JNCIAM 48,1539,1972
skin/mouse	toxic dose: 13 gm/kg/55W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application	JNCIAM 53,695,1974
subcutaneous/mouse	toxic dose: 8 gm/kg/40W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Tumorigenic: Tumors at site of application	JNCIAM 53,695,1974
subcutaneous/mouse	toxic dose: 5200 mg/kg/26W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Tumors at site of application	JNCIAM 48,1539,1972
subcutaneous/mouse	lowest published toxic dose: 894 mg/kg/52W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application	JACTDZ 6(4),479,1987

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	Lowest published lethal concentration: 1000 mg/m³/10M		NDRC** NDCrc-132,OCT1942
inhalation/rat	lethal concentration (50 percent kill): 180 ppm/6H		JEPTDQ 4(1),107,1980
intraperitoneal/mouse	lethal dose (50 percent kill): 300 mg/kg	Behavioral: Somnolence (general depressed activity)	ZAARAM 24,71,1974
oral/rat	lethal dose (50 percent kill): 1 gm/kg	Behavioral: Somnolence (general depressed activity)	ZAARAM 24,71,1974

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.005 ppm (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Suspected human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 12,77,1976
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 71,531,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 12,77,1976
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 71,531,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2A	IMEMDT 71,531,1999
TOXICOLOGY REVIEW		FCTOD7 44,1699,2006
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		MUREAV 802,1,2016

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	Carcinogen, JUL2008
Occupational Exposure Limit-JAPAN	2A carc, MAY2012
Occupational Exposure Limit-SWITZERLAND	carc 2, JAN2011

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLCARBAMOYLCHLORIDE-air	Carcinogen lowest feasible conc.	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 11, 1976
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health