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Registry of Toxic Effects of Chemical Substances (RTECS)

Butyronitrile

RTECS #

ET8750000

CAS #

109-74-0

Updated

July 2015

Molecular Weight

69.12

Molecular Formula

C4H7N

Synonyms

1-Cyanopropane
Butanenitrile
Butyric acid nitrile
Butyrylonitrile
n-Butanenitrile
n-Butyronitrile
Propyl cyanide
Propylkyanid (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,900,1986
skin /rabbit 395 mg open irritation test mildUCDS** 5/17/1960

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 200 ppm/6H (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FAATDF 20,365,1993
oral/rat 500 mg/kg (10D pregnant)Reproductive: Other effects to embryo or fetusTXAPA9 163,149,2000

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 249 ppm/1HLiver: Other changesCTOXAO 18,991,1981
inhalation/rat Lowest published lethal concentration: 1000 ppm/4HAIHAAP 23,95,1962
inhalation/rat lethal concentration (10 percent kill): 1848 ppm/1HBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands
HPV108 -,-,2003
inhalation/rat lethal concentration (50 percent kill): >1147 ppm/1HHPV108 -,-,2003
intraperitoneal/mouse lethal dose (50 percent kill): 38 mg/kgEye: Corneal damage

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
TXAPA9 59,589,1981
intraperitoneal/rat lethal dose (50 percent kill): 50 mg/kgBehavioral: Convulsions or effect on seizure threshold

Vascular: Regional or general arteriolar or venous dilation

Lung, Thorax, or Respiration: Dyspnea
38MKAJ 2C,4873,1982
intravenous/rabbit lowest published lethal dose: 980 mg/kgCOREAF 153,895,1911
oral/cat lowest published lethal dose: 20 mg/kgZAARAM 19,225,1969
oral/mouse lethal dose (50 percent kill): 27689 µg/kgNEZAAQ 39,423,1984
oral/mouse lowest published lethal dose: 69.11 mg/kgTOLED5 196S,S220,2010
oral/rabbit lowest published lethal dose: 50 mg/kgZAARAM 19,225,1969
oral/rat lethal dose (50 percent kill): 111 mg/kgHPV108 -,-,2003
oral/rat lethal dose (50 percent kill): 50 mg/kgBehavioral: Convulsions or effect on seizure threshold

Vascular: Regional or general arteriolar or venous dilation

Lung, Thorax, or Respiration: Dyspnea
38MKAJ 2C,4873,1982
skin/guinea pig lowest published lethal dose: 100 mg/kgKODAK* 21MAY1971
skin/rabbit lethal dose (50 percent kill): 500 µL/kgUCDS** 5/17/1960
skin/rabbit lethal dose (50 percent kill): 398 mg/kgHPV108 -,-,2003
subcutaneous/frog lowest published lethal dose: 3100 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
AIPTAK 5,161,1899
subcutaneous/guinea pig lowest published lethal dose: 100 mg/kgCOREAF 153,895,1911
subcutaneous/rabbit lowest published lethal dose: 10 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Respiratory stimulation
AIPTAK 5,161,1899

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,370,2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO N-BUTYRONITRILE-air10H time-weighted average 8 ppmNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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