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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Butanone, 3-methyl-

RTECS #

EL9100000

CAS #

563-80-4

Updated

September 2013

Molecular Weight

86.15

Molecular Formula

C5H10O

Synonyms

2-Acetyl propane
3-Methyl-2-butanone
3-Methylbutanone
Isopropyl methyl ketone
Methyl isopropyl ketone
Methyl isopropyl ketone (ACGIH)
MIPK

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H mildFCTXAV 16,819,1978
eye /rabbit 500 mg/24H mild85JCAE -,282,1986
skin /rabbit 500 mg/24H moderateFCTXAV 16,819,1978
skin /rabbit 500 mg open irritation test mildFCTXAV 16,637,1978

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
gene conversion and mitotic recombination/Saccharomyes cerevisiae12300 ppmMUREAV 149,339,1985

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 2500 mg/m3 (16D pre-19D pregnant)Reproductive: Other effects on female

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
HPV040 -,-,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 30000 mg/m3Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,422,1994
inhalation/rat Lowest published lethal concentration: 5700 ppm/4HTXAPA9 28,313,1974
inhalation/rat lethal concentration (50 percent kill): 6377 ppm/6HBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands
HPV040 -,-,2002
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kg38MKAJ 2C,4737,1982
intraperitoneal/rat lethal dose (50 percent kill): 800 mg/kg38MKAJ 2C,4737,1982
oral/mouse lethal dose (50 percent kill): 2572 mg/kgTOLED5 30,13,1986
oral/mouse lethal dose (50 percent kill): 3000 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,422,1994
oral/rat lethal dose (50 percent kill): 3078 mg/kgACMIK* 1988
oral/rat lethal dose (50 percent kill): 3000 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,422,1994
oral/rat lethal dose (50 percent kill): 3078 mg/kgBehavioral: AtaxiaHPV040 -,-,2002
skin/rabbit lethal dose (50 percent kill): 6350 mg/kgFCTXAV 16,819,1978

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1500 ppm/28D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV040 -,-,2002

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 20 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 200 ppm (705 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 200 ppm (700 mg/m3);KZW 400 ppm (1400 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 200 ppm (715 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 200 ppm (705 mg/m3), MAY2011
Occupational Exposure Limit-FRANCEVME 200 ppm (705 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 200 ppm (705 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 200 ppm (705 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 200 ppm (705 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 100 ppm (350 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 200 ppm (705 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 200 ppm (720 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 705 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ISOPROPYL KETONE-air10H time-weighted average 200 ppmNIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 83768; Number of Industries 3; Total Number of Facilities 68; Number of Occupations 7; Total Number of Employees Exposed 1055

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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