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Registry of Toxic Effects of Chemical Substances (RTECS)

n-Butanethiol

RTECS #

EK6300000

CAS #

109-79-5

Updated

September 2013

Molecular Weight

90.20

Molecular Formula

C4H10S

Synonyms

Butanethiol (OSHA)
Butyl mercaptan
Butyl mercaptan (DOT:OSHA)
n-Butyl mercaptan
n-Butyl mercaptan (ACGIH)
NCI-C60866

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 83 mgAIHAAP 19,171,1958

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/mouse 68 ppm/6H (6-16D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 8,170,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lethal concentration (50 percent kill): 770 ppm/30M85JCAE -,982,1986
inhalation/mouse lethal concentration (50 percent kill): 2500 ppm/4HLung, Thorax, or Respiration: Respiratory stimulation

Behavioral: Somnolence (general depressed activity)

Eye: Lacrimation
AIHAAP 19,171,1958
inhalation/rat lethal concentration (50 percent kill): 4020 ppm/4HLung, Thorax, or Respiration: Respiratory stimulation

Behavioral: Somnolence (general depressed activity)

Eye: Lacrimation
AIHAAP 19,171,1958
intraperitoneal/rat lethal dose (50 percent kill): 399 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Behavioral: Coma
AIHAAP 19,171,1958
oral/mouse lethal dose (50 percent kill): 3 gm/kg85JCAE -,982,1986
oral/rat lethal dose (50 percent kill): 1500 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Behavioral: Coma
AIHAAP 19,171,1958

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1114 ppm/6H/2W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0555470

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESActive registrationRBREV* -,357,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 ppm (1.5 mg/m3)DTLWS* 3,12,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 ppm (1.8 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 ppm (1.5 mg/m3);KZW 0.5 ppm (1.5 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 ppm (1.8 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (1.5 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 ppm (1.9 mg/m3), short term exposure limit 1.5 ppm (5.6 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.5 ppm (1.5 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 0.5 ppm (1.9 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (1.5 mg/m3), NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 0.5 ppm (1.5 mg/m3), JAN1993
Occupational Exposure Limit-KOREAtime-weighted average 0.5 ppm (1.5 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 ppm (1.5 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 ppm (1.8 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0.5 ppm (1.8 mg/m3), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 ppm (1.9 mg/m3), KZG-week 1 ppm (3.8 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1.5 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 10 ppm (35 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 ppm (1.5 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 10 ppm (35 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 10 ppm (35 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 ppm (1.5 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1-BUTANETHIOL-airceiling concentration 0.5 ppm/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 13785; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 8; Total Number of Employees Exposed 106; Total Number of Female Employees Exposed 3
National Occupational Hazard Survey 1974Hazard Code 13785; Number of Industries 2; Total Number of Facilities 71; Number of Occupations 7; Total Number of Employees Exposed 2764

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Mercaptans, 2542
NIOSH Analytical Method, 1996: n-Butyl mercaptan, 2525
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