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Registry of Toxic Effects of Chemical Substances (RTECS)

Borane, trifluoro-

RTECS #

ED2275000

CAS #

7637-07-2

Updated

September 2013

Molecular Weight

67.81

Molecular Formula

BF3

Synonyms

Boron fluoride
Boron trifluoride
Boron trifluoride (ACGIH:OSHA)
Fluorure de bore (French)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lethal concentration: >1000 ppm/3HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression
NTIS** OTS0546539
inhalation/guinea pig lethal concentration (50 percent kill): 109 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Blood: Hemorrhage
FATOAO 35,369,1972
inhalation/guinea pig Lowest published lethal concentration: 2100 mg/m3/5HEye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,201,1988
inhalation/guinea pig lethal concentration (50 percent kill): 110 mg/m3Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,201,1988
inhalation/mammal (species unspecified) lowest published toxic concentration: 8 mg/m3Lung, Thorax, or Respiration: CoughVCVN1* -,201,1988
inhalation/mouse lethal concentration (50 percent kill): 3460 mg/m3Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,201,1988
inhalation/mouse Lowest published lethal concentration: 2100 mg/m3/5HEye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,201,1988
inhalation/mouse lethal concentration (50 percent kill): 3460 mg/m3/2HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Blood: Hemorrhage
FATOAO 35,369,1972
inhalation/rat lethal concentration (50 percent kill): 1180 mg/m3/4H85GMAT -,27,1982
inhalation/rat Lowest published lethal concentration: 2100 mg/m3/5HEye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,201,1988
inhalation/rat lethal concentration (50 percent kill): 1180 mg/m3Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,201,1988

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 12800 ppb/7H/65D- intermittentLung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Nutritional and Gross Metabolic: Changes in: Other metals

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 22,263,1961
inhalation/guinea pig lowest published toxic concentration: 3 mg/m3/4H/17W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count
FATOAO 35(3),369,1972
inhalation/guinea pig lowest published toxic concentration: 30 mg/m3/15D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,201,1988
inhalation/guinea pig lowest published toxic concentration: 10 mg/m3/4H/16W- intermittentLung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count
VCVN1* -,202,1988
inhalation/guinea pig lowest published toxic concentration: 34 mg/m3/7H/61D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count
VCVN1* -,202,1988
inhalation/mouse lowest published toxic concentration: 30 mg/m3/15D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,201,1988
inhalation/rabbit lowest published toxic concentration: 10 mg/m3/4H/16W- intermittentLung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count
VCVN1* -,202,1988
inhalation/rabbit lowest published toxic concentration: 34 mg/m3/7H/61D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count
VCVN1* -,202,1988
inhalation/rat lowest published toxic concentration: 34 mg/m3/7H/61D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count
VCVN1* -,202,1988
inhalation/rat lowest published toxic concentration: 10 mg/m3/4H/16W- intermittentLung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count
VCVN1* -,202,1988
inhalation/rat lowest published toxic concentration: 12800 ppb/7H/65D- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 22,263,1961
inhalation/rat lowest published toxic concentration: 10 mg/m3/4H/17W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count
FATOAO 35(3),369,1972

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 1 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2.5 mg(F)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDair-ceiling concentration 1 ppm (3 mg/m3)DTLVS* 3,26,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit-AUSTRALIAceiling concentration 1 ppm (2.8 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 ppm (3 mg/m3);KZW 1 ppm (3 mg/m3), 2007
Occupational Exposure Limit-BELGIUMshort term exposure limit 1 ppm (3 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 1 ppm (3 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 2.5 mg(F)/m3, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (2.8 mg/m3), short term exposure limit 3 ppm (8.4 mg/m3), NOV2011
Occupational Exposure Limit-FINLANDtime-weighted average 2.5 mg(F)/m3, NOV2011
Occupational Exposure Limit-FRANCEVLE 1 ppm (3 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDshort term exposure limit 1 ppm (3 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.3 ppm (0.83 mg/m3), MAY2012
Occupational Exposure Limit-KOREAceiling concentration 1 ppm (3 mg/m3), 2006
Occupational Exposure Limit-MEXICOpeak 1 ppm (3 mg/m3), 2004
Occupational Exposure Limit-MEXICOtime-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 1 ppm (2.8 mg/m3), JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit-PERUshort term exposure limit 1 ppm (3 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDceiling concentration 1 ppm (3 mg/m3), JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg(F)/m3, KZG-week 4 mg(F)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-C 3 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINESshort term exposure limit 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2.5 mg(F)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 1 ppm (3 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 1 ppm (3 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 1 ppm (3 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 1 ppm (3 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BORON TRIFLUORIDE-airceiling concentration 1 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 12980; Number of Industries 6; Total Number of Facilities 79; Number of Occupations 10; Total Number of Employees Exposed 3819; Total Number of Female Employees Exposed 524
National Occupational Hazard Survey 1974Hazard Code 12980; Number of Industries 10; Total Number of Facilities 271; Number of Occupations 13; Total Number of Employees Exposed 4021

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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