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Registry of Toxic Effects of Chemical Substances (RTECS)

Beryllium

RTECS #

DS1750000

CAS #

7440-41-7

Updated

April 2017

Molecular Weight

9.01

Molecular Formula

Be

Synonyms

Beryllium (ACGIH:OSHA)
Beryllium-9
Glucinium
Glucinum
RCRA waste number P015

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adduct/Escherichia coli30 µmol/LMUREAV 89,95,1981
DNA adductHeLa cell/human30 µmol/LMUREAV 89,95,1981
DNA adductAscites tumor/mouse30 µmol/LMUREAV 89,95,1981
DNA inhibitionintravenous/non-mammalian species30 µmol/kgPHMCAA 12,298,1970

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intratracheal/rat lowest published toxic dose: 13 mg/kgTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma
ENVRAL 21,63,1980
intravenous/rabbit lowest published toxic dose: 20 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors
LANCAO 1,463,1950

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 0.8 mg/m3/50MLung, Thorax, or Respiration: Fibrosis (interstitial)

Blood: Hemorrhage

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
HBTME* -,415,2007
inhalation/rat Lowest published lethal concentration: 0.8 mg/m3/50MHBTME* -,415,2007
intratracheal/rat lethal dose (50 percent kill): 51 mg/kgSTGNBT -,23,1999
intravenous/rat lethal dose (50 percent kill): 496 µg/kgLiver: Hepatitis (hepatocellular necrosis), zonalLAINAW 15,176,1966

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 2 µg/m3/8H/26W- intermittentLung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes
FEREAC 67,70707,2002
inhalation/mammal (species unspecified) lowest published toxic concentration: 20 ng/m3/1H/17W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
STGNBT -,23,1999
inhalation/rat lowest published toxic concentration: 20 ng/m3/8H/26W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other proteins
STGNBT -,23,1999
oral/mouse lowest published toxic dose: 4000 µg/kg/20W- intermittentLung, Thorax, or Respiration: Other changesTOXID9 -,223,2008

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.00005 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 1,17,1972
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 23,143,1980
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 23,143,1980
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 100C,116,2012
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 100C,116,2012
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 100C,116,2012
TOXICOLOGY REVIEWCRTXB2 1,235,1972
TOXICOLOGY REVIEW85CVA2 5,63,1970
TOXICOLOGY REVIEWCTOXAO 6,497,1973
TOXICOLOGY REVIEWAEMBAP 40,239,1973
TOXICOLOGY REVIEWAJMEAZ 38,409,1965
TOXICOLOGY REVIEWNTIS** CONF-691001
TOXICOLOGY REVIEWAMTODM 3,209,1977
TOXICOLOGY REVIEWSCIEAS 201,298,1978
TOXICOLOGY REVIEWTOLED5 127,63,2002
TOXICOLOGY REVIEWTXAPA9 197,144,2004
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWENTOX* -,265,2005
TOXICOLOGY REVIEWMUREAV 544,313,2003
TOXICOLOGY REVIEWHTOPA* 1,701,2002
TOXICOLOGY REVIEWMUREAV 674,73,2009
TOXICOLOGY REVIEWTXAPA9 258,151,2012
TOXICOLOGY REVIEWEMMUEG 55,278,2014
TOXICOLOGY REVIEWFCTOD7 86,298,2015

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.002 mg/m3DTLVS* 3,24,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.002 mg/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.002 mg/m3, Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 0.005 mg/m3;KZW 0.02 mg/m3, polishing, inhal, sen, 2007
Occupational Exposure Limit-AUSTRIATRK-TMW 0.002 mg/m3;KZW 0.008 mg/m3, inhal, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.002 mg/m3, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.001 mg/m3 (dust), carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.001 mg/m3, NOV2011
Occupational Exposure Limit-HUNGARYceiling concentration 0.002 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.001 mg(Be)/m3 (dust), carc, sen, NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 0.002 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.002 mg/m3, 2A carc, a1 sen, s2 sen, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.002 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.002 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.002 mg/m3, carcinogen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.001 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.002 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.001 mg/m3, MAC(short term exposure limit) 0.003 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.001 mg/m3, short term exposure limit 0.003 mg/m3, Carcinogen, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.002 mg/m3, Carcinogen, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.002 mg/m3, carc 1, inhal, sen, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.002 mg/m3, short term exposure limit 0.005 mg/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.002 mg/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.002 mg/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.002 mg/m3, carc, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-airCarcinogen not to exceed 0.0005 mg(Be)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 11770; Number of Industries 22; Total Number of Facilities 421; Number of Occupations 29; Total Number of Employees Exposed 13938; Total Number of Female Employees Exposed 739
National Occupational Hazard Survey 1974Hazard Code 11770; Number of Industries 8; Total Number of Facilities 344; Number of Occupations 17; Total Number of Employees Exposed 10510

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182392/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Beryllium and compounds, as Be, 7102
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID125G
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