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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzidine, 3,3'-dimethoxy-

RTECS #

DD0875000

CAS #

119-90-4

Updated

March 2016

Molecular Weight

244.32

Molecular Formula

C14H16N2O2

Synonyms

3,3'-Dianisidine
3,3'-Dimethoxybenzidin (Czech)
3,3'-Dimethoxybenzidine
3,3'-Dimetossibenzodina (Italian)
4,4'-Diamino-3,3'-dimethoxybiphenyl
Acetamine Diazo Black RD
Acetamine Diazo Navy RD
Amacel Developed Navy SD
Azoene Fast Blue Base
Azogene Fast Blue B
Blue Base irga B
Blue Base NB
Blue BN Base
Brentamine Fast Blue B Base
C.I. 24110
C.I. Azoic Diazo Component 48
C.I. Disperse Black 6
Cellitazol B
Cibacete Diazo Navy Blue 2B
Diacel Navy DC
Diacelliton Fast Grey G
Dianisidine
Diato Blue Base B
Diazo Fast Blue B
DMB
Fast Blue B Base
Fast Blue DSC Base
Hiltonil Fast Blue B Base
Kayaku Blue B Base
Lake Blue B Base
Meisei Teryl Diazo Blue HR
Mitsui Blue B Base
Naphthanil Blue B Base
o,o'-Dianisidine
o-Dianisidin (Czech, German)
o-Dianisidina (Italian)
o-Dianisidine
RCRA waste number U091
Setacyl Diazo Navy R
Spectrolene Blue B

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/mouse100 mg/kgMUREAV 319,19,1993
DNA adductother cell types/Dog100 µmol/LCNREA8 44,1893,1984
DNA Damageliver/rat56 µmol/LTOSCF2 53,71,2000
DNA Damageliver/human100 µmol/LTOSCF2 53,71,2000
DNA Damageother cell types/human100 µmol/LTOSCF2 53,71,2000
DNA Damageoral/rat960 mg/kgTOSCF2 53,71,2000
DNA Damagelymphocyte/human200 µmol/L/2HTOSCF2 72,283,2003
DNA Damageoral/mouse600 mg/kgMUREAV 440,1,1999
micronucleus testliver/rat180 µmol/LTOSCF2 53,71,2000
morphological transformkidney/hamster80 µg/LBJCAAI 37,873,1978
mutation in microorganisms/Salmonella typhimurium1 µg/plate (-enzymatic activation step)IGAYAY 123,18,1982
mutation in microorganisms/Salmonella typhimurium0.1 mg/plate/40H (+enzymatic activation step)MUTAEX 24,433,2009
mutation in microorganisms/Salmonella typhimurium3 µg/plate (+enzymatic activation step)TOSCF2 56,351,2000
other mutation test systemsintraperitoneal/mouse100 mg/kgMUREAV 319,19,1993
other mutation test systemsother cell types/Dog100 µmol/LCNREA8 44,1893,1984
phage inhibition capacity/Escherichia coli100 mmol/LMDMIAZ 31,11,1979
sister chromatid exchangeovary/hamster500 µg/LENMUDM 7,1,1985
Unscheduled DNA SynthesisHeLa cell/human100 nmol/LCNREA8 38,2621,1978
Unscheduled DNA Synthesisliver/rat500 µmol/LENMUDM 3,11,1981

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/hamster lowest published toxic dose: 588 gm/kg/70W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
PAACA3 10,78,1969
oral/rat lowest published toxic dose: 12 gm/kg/56W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Ear: Tumors

Skin and Appendages: Tumors
GTPZAB 9(7),18,1965

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published lethal dose: 600 mg/kgAEXPBL 58,167,1907
oral/rat lowest published toxic dose: 960 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOSCF2 53,71,2000
oral/rat lethal dose (50 percent kill): 1920 mg/kg85JCAE -,723,1986

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 4,41,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 99,245,2010
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMSUDL 7,198,1987
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,198,1987
TOXICOLOGY REVIEWAEHLAU 23,6,1971
TOXICOLOGY REVIEWADCSAJ 13,271,1970
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWREPTED 19,547,2005
TOXICOLOGY REVIEWTCMUD8 23(Suppl 1),187,2003
TOXICOLOGY REVIEWMUREAV 612,58,2006
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIATRK-TMW 0.003 ppm (0.03 mg/m3);KZW 0.012 ppm (0.12 mg/m3), skin, 2007
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.003 ppm (0.03 mg/m3), carc 2, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-DIANISIDINE-BASED DYES-airCarcinogen lowest feasible conc.NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 80274; Number of Industries 4; Total Number of Facilities 92; Number of Occupations 11; Total Number of Employees Exposed 2481; Total Number of Female Employees Exposed 866
National Occupational Hazard Survey 1974Hazard Code 80274; Number of Industries 2; Total Number of Facilities 49; Number of Occupations 3; Total Number of Employees Exposed 122

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #ID-71
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