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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzidine, 3,3'-dimethyl-

RTECS #

DD1225000

CAS #

119-93-7

Updated

June 2017

Molecular Weight

212.32

Molecular Formula

C14H16N2

Synonyms

(1,1'-Biphenyl)-4,4'-diamine-3,3'-dimethyl-
2-Tolidin (German)
2-Tolidina (Italian)
2-Tolidine
3,3'-Dimethyl-4,4'-biphenyldiamine
3,3'-Dimethyl-4,4'-diphenyldiamine
3,3'-Dimethylbenzidin
3,3'-Dimethylbenzidine
3,3'-Dimethylbiphenyl-4,4'-diamine
3,3'-Dimethyldiphenyl-4,4'-diamine
3,3'-Tolidine
4,4'-Bi-o-toluidine
4,4'-Diamino-3,3'-dimethylbiphenyl
4,4'-Diamino-3,3'-dimethyldiphenyl
4,4'-Di-o-toluidine
Bianisidine
C.I. 37230
C.I. Azoic Diazo Component 113
Diaminoditolyl
Fast Dark Blue Base R
o,o'-Tolidine
o-Tolidin
o-Tolidine
o-Tolidine (ACGIH)
RCRA waste number U095
Tolidine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat10 µg/plateMUREAV 79,173,1980
Cytogenetic Analysisintraperitoneal/mouse100 mg/kgMUREAV 319,19,1993
Cytogenetic Analysisovary/hamster450 mg/LEMMUEG 10(Suppl 10),1,1987
DNA Damageoral/mouse200 mg/kgMUREAV 440,1,1999
DNA Damagelymphocyte/human500 µmol/L/2HTOSCF2 72,283,2003
DNA inhibitionoral/mouse100 mg/kgMUREAV 46,305,1977
micronucleus testoral/mouse16 mg/kgMUREAV 444,175,1999
morphological transformembryo/rat5 mg/LJNCIAM 51,799,1973
morphological transformkidney/hamster80 µg/LBJCAAI 37,873,1978
morphological transformembryo/mouse1 mg/LJNCIAM 52,1167,1974
mutation in mammalian somatic cellslymphocyte/mouse26 mg/LEMMUEG 12(Suppl 13),37,1988
mutation in microorganisms/Salmonella typhimurium100 nmol/plate (+enzymatic activation step)MUREAV 136,33,1984
mutation in microorganisms/Salmonella typhimurium4 µg/plate (-enzymatic activation step)BJCAAI 37,873,1978
mutation in microorganismslymphocyte/mouse105 mg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),37,1988
mutation in microorganisms/Salmonella typhimurium3 µg/plate (+enzymatic activation step)TOSCF2 56,351,2000
mutation in microorganisms/Salmonella typhimurium300 µg/plate/20M (+enzymatic activation step)MUTAEX 20,217,2005
mutation in microorganisms/Salmonella typhimurium600 µg/plate/48H (+enzymatic activation step)MUTAEX 20,217,2005
other mutation test systemsintraperitoneal/mouse100 mg/kgMUREAV 319,19,1993
sister chromatid exchangeovary/hamster5 mg/LEMMUEG 10(Suppl 10),1,1987
sister chromatid exchangeparenteral/chicken169 µg/kg47JMAE -,137,1982
sister chromatid exchangelymphocyte/rabbit50 mg/LMUREAV 89,197,1981
Unscheduled DNA Synthesisliver/hamster1 µmol/LMUREAV 136,255,1984
Unscheduled DNA SynthesisHeLa cell/human1 µmol/LCNREA8 38,2621,1978
Unscheduled DNA Synthesisliver/rat1 µmol/LMUREAV 136,255,1984

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 5040 mg/kg/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
JNCIAM 45,283,1970
oral/rat lowest published toxic dose: 4500 mg/kg/27D- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 28,924,1968
subcutaneous/rat lowest published toxic dose: 1650 mg/kg/33W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
VOONAW 20(2),53,1974
subcutaneous/rat toxic dose: 9 gm/kg/51W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Ear: Tumors
CANCAR 3,789,1950
subcutaneous/rat toxic dose: 5040 mg/kg/56W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Ear: Tumors

Endocrine: Tumors
GTPZAB 9(7),18,1965
subcutaneous/rat toxic dose: 3240 mg/kg/34W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors

Skin and Appendages: Tumors
JNCIAM 45,283,1970

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published lethal dose: 125 mg/kgCBCCT* 6,64,1954
oral/Dog lowest published lethal dose: 600 mg/kgAEXPBL 58,167,1907

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-skinDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 1,87,1972
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 99,245,2010
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 1,87,1972
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWREPTED 19,547,2005
TOXICOLOGY REVIEWMUREAV 612,58,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUTAEX 31,117,2016
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIACarcinogen, JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 0.003 ppm (0.03 mg/m3);KZW 0.012 ppm (0.12 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMSkin, MAR2002
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAskin, 2006
Occupational Exposure Limit-NEW ZEALANDskin, JAN2002
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.003 ppm (0.03 mg/m3), carc 2, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-TOLIDINE-airCarcinogen ceiling concentration 0.02 mg/m3/60MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84756; Number of Industries 8; Total Number of Facilities 854; Number of Occupations 20; Total Number of Employees Exposed 9640; Total Number of Female Employees Exposed 6005
National Occupational Hazard Survey 1974Hazard Code 84756; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 5; Total Number of Employees Exposed 421

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-71
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