Benzenethiol

RTECS #

DC0525000

CAS #

108-98-5
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

110.18

Molecular Formula

C₆H₆S

Synonyms

Mercaptobenzene
Phenol, thio-
Phenyl mercaptan
Phenyl mercaptan (ACGIH:OSHA)
RCRA waste number P014
Thiofenol (Czech)
Thiophenol
USAF XR-19

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	108 mg	severe	AIHAAP 19,171,1958

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	500 mg/kg (6-15D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Other effects to embryo or fetus	NTIS** PB94-155009
oral/rat	18 mg/kg (multigenerations)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB96-211735
oral/rat	18 mg/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Urogenital system	NTIS** #PB96-211735
oral/rat	315 mg/kg (7D male/7D prior to copulation/21D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB96-211735
oral/rat	5145 mg/kg (21W prior to copulation)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB96-211735
oral/rat	9 mg/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB96-211735
oral/rat	9 mg/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system	NTIS** #PB96-211735
oral/rat	500 mg/kg (6-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	NTIS** #PB94-155009
oral/rat	500 mg/kg (6-15D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	NTIS** #PB94-155009
oral/rat	500 mg/kg (6-15D pregnant)	Reproductive: Other effects to embryo or fetus	NTIS** #PB94-155009
oral/rat	245 mg/kg (7D prior to copulation)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	HPV134 -,-,2004
oral/rat	200 mg/kg (6-15D pregnant)	Reproductive: Other effects on female	HPV134 -,-,2004
oral/rat	350 mg/kg (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	HPV134 -,-,2004
oral/rabbit	140 mg/kg (6-19D pregnant)	Reproductive: Other effects on female	HPV134 -,-,2004

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 0.6 mg/m³/1M	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	TOVEFN (6),38,1995
inhalation/mouse	lethal concentration (50 percent kill): 25 ppm		HPV134 -,-,2004
inhalation/mouse	lethal concentration (50 percent kill): 28 ppm/4H	Lung, Thorax, or Respiration: Respiratory stimulation Behavioral: Somnolence (general depressed activity) Eye: Lacrimation	AIHAAP 19,171,1958
inhalation/mouse	lethal concentration (50 percent kill): 514 mg/m³/2H		TOVEFN (6),38,1995
inhalation/rat	lethal concentration (50 percent kill): 634 mg/m³/4H		TOVEFN (6),38,1995
inhalation/rat	lowest published toxic concentration: 9.4 mg/m³/4H	Behavioral: Alteration of classical conditioning Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Renal function tests depressed	TOVEFN (6),38,1995
inhalation/rat	lowest published toxic concentration: 9.4 mg/m³/4H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	TOVEFN (6),38,1995
inhalation/rat	lowest published toxic concentration: 2.4 mg/m³/4H	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Other changes	TOVEFN (6),38,1995
inhalation/rat	lethal concentration (50 percent kill): 33 ppm/4H	Lung, Thorax, or Respiration: Respiratory stimulation Behavioral: Somnolence (general depressed activity) Eye: Lacrimation	AIHAAP 19,171,1958
intraperitoneal/mouse	lethal dose (50 percent kill): 25 mg/kg		NTIS** AD277-689
intraperitoneal/rat	lethal dose (50 percent kill): 9800 µg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Coma Lung, Thorax, or Respiration: Respiratory depression	AIHAAP 19,171,1958
intraperitoneal/rat	lethal dose (50 percent kill): 9.8 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Coma	HPV134 -,-,2004
intraperitoneal/rat	lethal dose (50 percent kill): 39 mg/kg	Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) Behavioral: Coma	TOVEFN (6),38,1995
intraperitoneal/rat	lethal dose (50 percent kill): 39 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	TOVEFN (6),38,1995
oral/mouse	lethal dose (50 percent kill): 267 mg/kg	Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea	NTIS** OTS0557376
oral/mouse	lethal dose (50 percent kill): 266 mg/kg		GISAAA 1,7,1994
oral/rat	lethal dose (50 percent kill): 200 mg/kg		TOVEFN (6),38,1995
oral/rat	lethal dose (16 percent kill): 140 mg/kg	Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) Behavioral: Coma	TOVEFN (6),38,1995
oral/rat	lethal dose (16 percent kill): 140 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	TOVEFN (6),38,1995
oral/rat	lethal dose (50 percent kill): 355 mg/kg	Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) Behavioral: Coma	TOVEFN (6),38,1995
oral/rat	lethal dose (50 percent kill): 355 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	TOVEFN (6),38,1995
oral/rat	lethal dose (50 percent kill): 46200 µg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Coma Lung, Thorax, or Respiration: Respiratory depression	AIHAAP 19,171,1958
oral/rat	lethal dose (50 percent kill): 46.2 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression	HPV134 -,-,2004
oral/rat	lowest published lethal dose: 302 mg/kg		TOVEFN (6),38,1995
oral/wild bird	lethal dose (50 percent kill): 24 mg/kg		TXAPA9 21,315,1972
skin/rabbit	lethal dose (50 percent kill): 134 mg/kg	Behavioral: Muscle weakness Behavioral: Ataxia Lung, Thorax, or Respiration: Cyanosis	AIHAAP 19,171,1958
skin/rat	lethal dose (50 percent kill): 300 mg/kg	Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression Skin: After topical application: Primary irritation	AIHAAP 19,171,1958
skin/rat	lethal dose (50 percent kill): 300 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Coma	HPV134 -,-,2004

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rabbit	lowest published toxic dose: 420 mg/kg/14D- intermittent	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #PB94-201183
oral/rabbit	lowest published toxic dose: 700 mg/kg/14D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** #PB94-155009
oral/rabbit	lowest published toxic dose: 80 mg/kg/8D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV134 -,-,2004
oral/rat	lowest published toxic dose: 200 mg/kg/10D- intermittent	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #PB94-155009
oral/rat	lowest published toxic dose: 500 mg/kg/10D- intermittent	Behavioral: Fluid intake Liver: Changes in liver weight	NTIS** #PB94-155009
oral/rat	lowest published toxic dose: 27 mg/kg/30D- intermittent	Cardiac: EKG changes not diagnostic of above Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	GISAAA 1,7,1994
oral/rat	lowest published toxic dose: 1.825 mg/kg/26W- intermittent	Behavioral: Change in motor activity (specific assay) Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	GISAAA 1,7,1994
oral/rat	lowest published toxic dose: 18.25 mg/kg/26W- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	GISAAA 1,7,1994
oral/rat	lowest published toxic dose: 5145 mg/kg/21W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #PB96-211735
oral/rat	lowest published toxic dose: 1323 mg/kg/21W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight	NTIS** #PB96-211735
oral/rat	lowest published toxic dose: 1323 mg/kg/21W- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Changes in kidney weight	NTIS** #PB96-211735
oral/rat	lowest published toxic dose: 1323 mg/kg/21W- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	NTIS** #PB96-211735
oral/rat	lowest published toxic dose: 2646 mg/kg/21W- intermittent	Liver: Other changes Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	NTIS** #PB96-211735
skin/rabbit	lowest published toxic dose: 500 µL/kg/5D- intermittent	Skin: After systemic exposure: Dermatitis, other	NTIS** OTS0557376

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 ppm (skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		REPTED 25,192,2008
TOXICOLOGY REVIEW		RTOPDW 54,247,2009

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.5 ppm (2.3 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.4 ppm (2 mg/m³);KZW 0.8 ppm (4 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.5 ppm (2.3 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.5 ppm (2.3 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	short term exposure limit 0.5 ppm (2.3 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.5 ppm (2 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.5 ppm (2.3 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.5 ppm (2 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.5 ppm (2 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.5 ppm (2.3 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.5 ppm (2 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,5 ppm (2,3 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.2 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.5 ppm (2.3 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 2 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BENZENETHIOL-air	ceiling concentration 0.1 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code X4092; Number of Industries 1; Total Number of Facilities 24; Number of Occupations 2; Total Number of Employees Exposed 879; Total Number of Female Employees Exposed 187

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health