Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, 1,2,4-trichloro-

RTECS #

DC2100000

CAS #

120-82-1

Updated

July 2014

Molecular Weight

181.44

Molecular Formula

C6H3Cl3

Synonyms

1,2,4-Trichlorobenzene
1,2,4-Trichlorobenzene (ACGIH)
1,2,4-Trichlorobenzol
1,2,5-Trichlorobenzene
1,3,4-Trichlorobenzene
Hostetex L-pec
Trojchlorobenzen (Polish)
unsym-Trichlorobenzene

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 1950 mg/13W- intermittent moderateAEHLAU 30,165,1975

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testintraperitoneal/mouse210 mg/kg/24HMUTAEX 2,111,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 750 mg/kg (3D prior to copulation)Reproductive: Maternal effects: Uterus, cervix, vaginaJTEHD6 8,489,1981
oral/rat 3600 mg/kg (multigeneration)Reproductive: Other effects on male

Reproductive: Other effects on female

Reproductive: Effects on newborn: Other neonatal measures or effects
HPV173 -,-,2002
oral/rat 1800 mg/kg (9-13D pregnant)Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
ENVRAL 31,362,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 2336 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** OTS0571797

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): >2500 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
inhalation/mammal (species unspecified) lowest published toxic concentration: 200 mg/m3Behavioral: Alteration of classical conditioningVCVGK* -,26,1984
intraperitoneal/mouse lethal dose (50 percent kill): 1223 mg/kgMUTAEX 2,111,1987
intraperitoneal/rat lowest published toxic dose: 2 mg/kgKidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 111,69,1991
intraperitoneal/rat lowest published toxic dose: 1 mg/kgLiver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TXAPA9 111,69,1991
oral/mouse lethal dose (50 percent kill): 756 mg/kgVCVGK* -,26,1984
oral/mouse lethal dose (50 percent kill): 300 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
NAIZAM 29,569,1978
oral/rat lethal dose (50 percent kill): 756 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
AOHYA3 12,209,1969
oral/rat lethal dose (50 percent kill): 756 mg/kgHPV173 -,-,2002
skin/rabbit lowest published lethal dose: 6100 mg/kgVCVGK* -,26,1984
skin/rat lethal dose (50 percent kill): 6139 mg/kgHPV173 -,-,2002
skin/rat lethal dose (50 percent kill): 6139 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
AOHYA3 12,209,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 100 mg/m3/4Y- intermittentBehavioral: Headache

Liver: Other changes

Blood: Changes in cell count (unspecified)
VCVGK* -,27,1994
inhalation/mouse lowest published toxic concentration: 500 mg/m3/7H/3W- intermittentLiver: Fatty liver degeneration

Blood: Changes in cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,27,1994
inhalation/rat lowest published toxic concentration: 100 mg/m3/17W- intermittentBlood: Changes in leukocyte (WBC) countVCVGK* -,27,1994
inhalation/rat lowest published toxic concentration: 25 ppm/26W- intermittentLiver: Other changesVCVGK* -,27,1994
oral/mouse lowest published toxic dose: 13104 mg/kg/26W- continuousLiver: Other changes

Liver: Tumors
CMSHAF 1,279,1972
oral/mouse lowest published toxic dose: 6048 mg/kg/12W- continuousLiver: Other changes

Liver: Changes in liver weight
CMSHAF 1,153,1972
oral/rat lowest published toxic dose: 280 mg/kg/14D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesTXAPA9 37,170,1976
oral/rat lowest published toxic dose: 7380 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
DCTODJ 11,11,1988
oral/rat lowest published toxic dose: 280 mg/kg/14D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
BCPCA6 27,361,1978
oral/rat lowest published toxic dose: 181 mg/kg/2W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterasesVCVGK* -,27,1994
skin/mammal (species unspecified) lowest published toxic dose: 840 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
VCVGK* -,26,1994
skin/mammal (species unspecified) lowest published toxic dose: 12600 mg/kg/4W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuseVCVGK* -,26,1994

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 5 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 763,36,2014

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAceiling concentration 5 ppm (37 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 ppm (15.1 mg/m3);KZW 5 ppm (37.8 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (15.1 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 5 ppm (37.8 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (15 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 15.1 mg/m3 (2 ppm);short term exposure limit 37.8 mg/m3 (5 ppm), skin, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 2 ppm (15 mg/m3), short term exposure limit 5 ppm (38 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 2 ppm (15.1 mg/m3), VLE 5 ppm (37.8 mg/m3), Skin, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 15.1 mg/m3, short term exposure limit 37.8 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (15 mg/m3), short term exposure limit 5 ppm (37.8 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAceiling concentration 5 ppm (40 mg/m3), 2006
Occupational Exposure Limit-MEXICOpeak 5 ppm (40 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 5 ppm (37 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (14,8 mg/m3); short term exposure limit 5 ppm (37 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 2 ppm (15 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (38 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 15.1 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm;short term exposure limit 5 ppm, skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,2,4-TRICHLOROBENZENE-airceiling concentration 5 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 83334; Number of Industries 6; Total Number of Facilities 78; Number of Occupations 14; Total Number of Employees Exposed 4033; Total Number of Female Employees Exposed 1463
National Occupational Hazard Survey 1974Hazard Code 83334; Number of Industries 4; Total Number of Facilities 74; Number of Occupations 8; Total Number of Employees Exposed 1687

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polychlorobenzenes, 5517
On EPA IRIS database
TOP