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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, divinyl-

RTECS #

CZ9370000

CAS #

1321-74-0

Updated

December 2014

Molecular Weight

130.20

Molecular Formula

C10H10

Synonyms

Benzene, diethenyl- (9CI)
Diethenylbenzene
Divinyl benzene
Divinyl benzene (ACGIH)
Divinylbenzene
Vinylstyrene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisinhalation/mouse53 ppm/6H/3D-continuousMUREAV 370,107,1996
micronucleus testinhalation/mouse53 ppm/6H/3D-continuousMUREAV 370,107,1996
sister chromatid exchangeinhalation/mouse53 ppm/6H/3D-continuousMUREAV 370,107,1996

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published lethal dose: 10 mL/kgLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
AMIHAB 19,403,1959
oral/rat lethal dose (50 percent kill): 5 mL/kgVCVGH* -,189,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse : 200 ppm/6H/2D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-534
inhalation/mouse : 100 ppm/6H/17D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-534
inhalation/mouse : 25 ppm/6H/17D- intermittentOlfaction: Other olfaction effects

Endocrine: Changes in thymus weight
NTPTR* NTP-TR-534
inhalation/mouse : 25 ppm/6H/17D- intermittentOlfaction: Other olfaction effects

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
NTPTR* NTP-TR-534
inhalation/mouse : 200 ppm/6H/17D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Multiple effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
NTPTR* NTP-TR-534
inhalation/mouse : 200 ppm/6H/14W- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-534
inhalation/mouse : 25 ppm/6H/14W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-534
inhalation/mouse : 100 ppm/6H/14W- intermittentBehavioral: Sleep

Behavioral: Somnolence (general depressed activity)
NTPTR* NTP-TR-534
inhalation/mouse : 100 ppm/6H/105W- intermittentLung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-534
inhalation/mouse : 30 ppm/6H/105W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-534
inhalation/mouse : 10 ppm/6H/105W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma
NTPTR* NTP-TR-534
inhalation/mouse : 10 ppm/6H/105W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes
NTPTR* NTP-TR-534
inhalation/rat : 400 ppm/6H/16D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-534
inhalation/rat : 50 ppm/6H/16D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightNTPTR* NTP-TR-534
inhalation/rat : 200 ppm/6H/16D- intermittentLiver: Changes in liver weightNTPTR* NTP-TR-534
inhalation/rat : 100 ppm/6H/16D- intermittentOlfaction: Other olfaction effects

Eye: Other eye effects
NTPTR* NTP-TR-534
inhalation/rat : 400 ppm/6H/105W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-534
inhalation/rat : 400 ppm/6H/53W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-534
inhalation/rat : 400 ppm/6H/105W- intermittentKidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Kidney tumors

Skin and Appendages: Tumors
NTPTR* NTP-TR-534
inhalation/rat : 400 ppm/6H/105W- intermittentLung, Thorax, or Respiration: Other changesNTPTR* NTP-TR-534
inhalation/rat : 200 ppm/6H/105W- intermittentKidney, Ureter, and Bladder: Kidney tumorsNTPTR* NTP-TR-534
inhalation/rat : 100 ppm/6H/105W- intermittentBrain and Coverings: TumorsNTPTR* NTP-TR-534
inhalation/rat : 100 ppm/6H/105W- intermittentOlfaction: Other olfaction effectsNTPTR* NTP-TR-534
inhalation/rat : 50 ppm/6H/14W- intermittentOlfaction: Other olfaction effects

Eye: Other eye effects
NTPTR* NTP-TR-534
inhalation/rat : 25 ppm/6H/14W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
NTPTR* NTP-TR-534
inhalation/rat : 200 ppm/6H/14W- intermittentCardiac: Changes in heart weight

Related to Chronic Data: Changes in testicular weight
NTPTR* NTP-TR-534
inhalation/rat : 100 ppm/6H/14W- intermittentOlfaction: Other olfaction effectsNTPTR* NTP-TR-534

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWTOLED5 204,148,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (53 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 9 ppm (50 mg/m3);KZW 18 ppm (100 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (54 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (50 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 2 ppm (11 mg/m3), NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (50 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (50 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (53 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 ppm (53 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (50 mg/m3), JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIVINYL BENZENE-air10H time-weighted average 10 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 83286; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 11
National Occupational Hazard Survey 1974Hazard Code 83286; Number of Industries 5; Total Number of Facilities 164; Number of Occupations 14; Total Number of Employees Exposed 12271

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000
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