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Registry of Toxic Effects of Chemical Substances (RTECS)

Bacillus subtilis carlsberg

RTECS #

CO9550000

CAS #

9014-01-1

Updated

September 2013

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

Alcalase
ALK-enzyme
Bacillopeptidase A
Bacillopeptidase B
Bioprase
Colistinase
E.C. 3.4.21.14
E.C. 3.4.4.16
Maxatase
Nagarse
SP 266
Subtilisin (9CI)
Subtilisin (ACGIH)
Subtilisin bpn'
Subtilisin carlsburg
Subtilisin NOVO
Subtilisins
Subtilopeptidase A
Subtilopeptidase B
Subtilopeptidase bpn'
Subtilopeptidase C
Thermoase PC-10

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 3 mg moderateFCTXAV 7,581,1969

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intratracheal/guinea pig lowest published toxic dose: 20 µg/kgImmunological Including Allergic: Increase in humoral responseTOXID9 60,175,2001
oral/rat lethal dose (50 percent kill): 3700 mg/kgFCTXAV 7,581,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 0.1 pph/3D- intermittentLung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Increase in humoral response
TOXID9 60,10,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 0.00006 mg/m3DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.0003 mg/m3DTLVS* 3,236,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.00006 mg/m3, JUL2008
Occupational Exposure Limit-DENMARKceiling concentration 0.00006 mg/m3, MAY2011
Occupational Exposure Limit-ICELANDshort term exposure limit 0.0006 mg/m3, sen, NOV2011
Occupational Exposure Limit-MEXICOpeak 0.00006 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 0.00006 mg/m3, sen, JAN2002
Occupational Exposure Limit-PERUshort term exposure limit 0,00006 mg/m3, JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 1 glycine unit/m3, ceiling concentration 3 glycine unit/m3, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.00006 mg/m3, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.04 µg/m3, sen, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SUBTILISINS-airshort term exposure limit 0.00006 mg/m3/60MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X1796; Number of Industries 3; Total Number of Facilities 225; Number of Occupations 5; Total Number of Employees Exposed 5548; Total Number of Female Employees Exposed 1814

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8800
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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