Asphalt
RTECS #
CI9900000
CAS #
Updated
December 2018
Molecular Weight
N/R
Molecular Formula
N/R
Synonyms
Asphalt fumes (ACGIH)
Asphalt, petroleum
Asphaltum
Bitumen
Bitumen fumes
Judean pitch
Mineral pitch
Petroleum asphalt
Petroleum bitumen
Petroleum pitch
Petroleum roofing tar
Road asphalt
Asphalt, petroleum
Asphaltum
Bitumen
Bitumen fumes
Judean pitch
Mineral pitch
Petroleum asphalt
Petroleum bitumen
Petroleum pitch
Petroleum roofing tar
Road asphalt
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA adduct | skin/mouse | 600 mg/kg | CRNGDP 9,1253,1988 |
| DNA Damage | other cell types/rat | 641 µg/L | MUREAV 557,137,2004 |
| micronucleus test | other cell types/rat | 57.8 µg/L | MUREAV 557,137,2004 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intramuscular/mouse | lowest published toxic dose: 12 gm/kg/12W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Tumorigenic: Tumors at site of application | ARPAAQ 70,372,1960 |
| intramuscular/rat | lowest published toxic dose: 5400 mg/kg/24W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Tumorigenic: Facilitates action of known carcinogens | ARPAAQ 70,372,1960 |
| skin/mouse | lowest published toxic dose: 130 gm/kg/81W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors | HYSAAV 33(4-6),180,1968 |
| skin/mouse | toxic dose: 69 gm/kg/43W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors | HYSAAV 33(4-6),180,1968 |
| skin/mouse | lowest published toxic dose: 905 gm/kg/2Y- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors | IMSUAI 34,255,1965 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lethal concentration (50 percent kill): >94.4 mg/m3 | HPV123 -,-,2002 | |
| oral/rat | lethal dose (50 percent kill): >5000 mg/kg | Gastrointestinal: Hypermotility, diarrhea | HPV123 -,-,2002 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/human | lowest published toxic dose: 10 mg/m3/5.5Y- intermittent | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough Gastrointestinal: Changes in structure or function of salivary glands | ARTODN 81,35,2007 |
| inhalation/human | lowest published toxic dose: 10 mg/m3/9Y- intermittent | Lung, Thorax, or Respiration: Other changes Gastrointestinal: Changes in structure or function of salivary glands Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | ARTODN 81,35,2007 |
| inhalation/mouse | lowest published toxic concentration: 35 mg/m3/10D- intermittent | Immunological Including Allergic: Decrease in humoral immune response | TOXID9 60,27,2001 |
| inhalation/rat | lowest published toxic concentration: 100 mg/m3/14W- intermittent | Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | HPV123 -,-,2002 |
| inhalation/rat | lowest published toxic concentration: 100 mg/m3/6H/14W- intermittent | Olfaction: Tumors Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOLED5 135,S140,2002 |
| intratracheal/rat | lowest published toxic dose: 1.35 mg/kg/3D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | JJTHEC 65,1247,2002 |
| intratracheal/rat | lowest published toxic dose: 26.64 mg/kg/3D- intermittent | Blood: Changes in bone marrow not included in above | JJTHEC 65,1247,2002 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.5 mg/m3 (inhal) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 35,39,1985 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,133,1987 |
| TOXICOLOGY REVIEW | TOLED5 254,52,2016 | |
| TOXICOLOGY REVIEW | RTOPDW 59,270,2011 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,101,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 mg/m3 (fume) | DTLVS* 3,19,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 5 mg/m3, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 mg/m3, JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 mg/m3 (fume), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 1 mg/m3, MAY2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 mg/m3, NOV2011 | |
| Occupational Exposure Limit-JAPAN | 2B carc, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 mg/m3 (fume), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.5 mg/m3, JUL2005 | |
| Occupational Exposure Limit-POLAND | time-weighted average 5 mg/m3 (fume), short term exposure limit 15 mg/m3 (fume), JAN1999 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 10 mg/m3, carc 3, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 5 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 5 mg/m3;short term exposure limit 10 mg/m3, OCT2007 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ASPHALT FUMES-air | Carcinogen ceiling concentration 5 mg/m3/15M | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 90320; Number of Industries 177; Total Number of Facilities 26349; Number of Occupations 109; Total Number of Employees Exposed 471039; Total Number of Female Employees Exposed 18959 | |
| National Occupational Hazard Survey 1974 | Hazard Code 90320; Number of Industries 175; Total Number of Facilities 38326; Number of Occupations 111; Total Number of Employees Exposed 573807 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health