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Registry of Toxic Effects of Chemical Substances (RTECS)

Arsenic acid, calcium salt (2:3)

RTECS #

CG0830000

CAS #

7778-44-1; 1333-25-1

Updated

March 2016

Molecular Weight

398.08

Molecular Formula

As2O8·3Ca

Synonyms

Arseniate de calcium (French)
Calcium arsenate
Calcium orthoarsenate
Calciumarsenat
Chip-Cal granular
Cucumber dust
Fencal
Kalziumarseniat (German)
Kilmag
Pencal
Spra-cal
Tricalcium arsenate
Tricalciumarsenat (German)
Turf-cal

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intratracheal/hamster lowest published toxic dose: 120 mg/kg/15W- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CALEDQ 27,99,1985
intratracheal/hamster toxic dose: 214 mg/kg/15W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
IJCNAW 40,220,1987
intratracheal/rat lowest published toxic dose: 1600 µg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
IJCNAW 24,786,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/Dog lethal dose (50 percent kill): 38 mg/kg85DPAN -,-,1971/1976
oral/mouse lethal dose (50 percent kill): 794 mg/kgAMRL** TR-72-62,1972
oral/rabbit lowest published lethal dose: 50 mg/kgJPETAB 39,246,1930
oral/rat lethal dose (50 percent kill): 20 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Dehydration
AFDOAQ 15,122,1951
skin/rat lethal dose (50 percent kill): 2400 mg/kg28ZEAL 5,35,1976

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 24 gm/kg/2Y- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
PHRPA6 56,1610,1941

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg(As)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 23,39,1980
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMSUDL 7,100,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 100C,85,2012
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 23,39,1980
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMSUDL 7,100,1987
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 100C,85,2012
TOXICOLOGY REVIEW85DHAX As,-,1977
TOXICOLOGY REVIEWTOLED5 133,1,2002

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,160,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(As)/m3DTLVS* 3,16,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 mg/m3, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 1 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg(As)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(As)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit-POLANDtime-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(As)/m3, carc 1, inhal, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(As)/m3, carc, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA)-cancer hazardCFRGBR 29,1910.1018,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-airCarcinogen ceiling concentration 0.002 mg(As)/m3/15MNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen
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