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Registry of Toxic Effects of Chemical Substances (RTECS)

Arsine

RTECS #

CG6475000

CAS #

7784-42-1

Updated

March 2016

Molecular Weight

77.95

Molecular Formula

AsH3

Synonyms

Arsenic hydrid
Arsenic hydride
Arsenic trihydride
Arseniuretted hydrogen
Arsenous hydride
Arsenowodor (Polish)
Arsenwasserstoff (German)
Arsine (ACGIH:OSHA)
Hydrogen arsenide

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 150 mg/m3/20MHBAMAK 4,1306,1935
inhalation/Dog lethal concentration (50 percent kill): 350 mg/m3/30MNTIS** PB158-508
inhalation/Dog lethal concentration (50 percent kill): 0.5 mg/m3/15MVCVN5* -,87,1993
inhalation/domestic animal lethal concentration (50 percent kill): 1 gm/m3/10MNTIS** PB158-508
inhalation/frog Lowest published lethal concentration: 4500 mg/m3/3HPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Altered sleep time (including change in righting reflex)

Cardiac: Other changes
AEXPBL 80,288,1917
inhalation/human Lowest published lethal concentration: 250 mg/m3/30MLung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Nausea or vomiting
HBTME* -,367,2007
inhalation/human lowest published toxic concentration: 3 ppmBlood: Pigmented or nucleated red blood cells

Blood: Other hemolysis with or without anemia
AMIHAB 21,132,1960
inhalation/human Lowest published lethal concentration: 25 ppm/30MBlood: Other hemolysis with or without anemia

Endocrine: Change in GH
AEHLAU 19,133,1969
inhalation/human Lowest published lethal concentration: 300 ppm/5MTABIA2 3,231,1933
inhalation/man lowest published toxic concentration: 325 µg/m3Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Hematuria
AEHLAU 34,224,1979
inhalation/monkey Lowest published lethal concentration: 600 mg/m3/1HHBAMAK 4,1306,1935
inhalation/mouse lethal concentration (50 percent kill): 250 mg/m3/10MNTIS** PB158-508
inhalation/mouse lethal concentration (50 percent kill): 0.5 mg/m3/2MVCVN5* -,87,1993
inhalation/mouse lethal concentration (50 percent kill): 0.1 mg/m3/15MVCVN5* -,87,1993
inhalation/mouse lethal concentration (50 percent kill): 0.05 gm/m3/2HTPKVAL 9,7,1967
inhalation/mouse lethal concentration (50 percent kill): 17.2 ppm/2HTPKVAL 9,7,1967
inhalation/mouse Lowest published lethal concentration: 0.63 ppm/30MTOXID9 72,160,2003
inhalation/mouse Lowest published lethal concentration: 0.5 ppm/1HTOXID9 72,160,2003
inhalation/mouse Lowest published lethal concentration: 0.13 ppm/4HTOXID9 72,160,2003
inhalation/mouse Lowest published lethal concentration: 0.06 ppm/8HTOXID9 72,160,2003
inhalation/rabbit lethal concentration (50 percent kill): 200 ppm/10MENTOX* -,173,2005
inhalation/rabbit lethal concentration (50 percent kill): 0.4 mg/m3/15MPeripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Gastrointestinal: Necrotic changes

Kidney, Ureter, and Bladder: Hematuria
VCVN5* -,87,1993
inhalation/rabbit lethal concentration (50 percent kill): 650 mg/m3/10MNTIS** PB158-508
inhalation/rat lethal concentration (50 percent kill): 0.3 mg/m3/15MVCVN5* -,87,1993
inhalation/rat lethal concentration (50 percent kill): 390 mg/m3/10MNTIS** PB158-508
inhalation/rat lethal concentration (50 percent kill): 240 ppm/30MLung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria

Blood: Hemorrhage
ENTOX* -,173,2005
inhalation/rat lethal concentration (50 percent kill): 178 ppm/1HLung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria

Blood: Hemorrhage
ENTOX* -,173,2005
inhalation/rat lethal concentration (50 percent kill): 45 ppm/4HLung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria

Blood: Hemorrhage
ENTOX* -,173,2005
inhalation/rat lethal concentration (50 percent kill): 120 ppm/10MLung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria

Blood: Hemorrhage
ENTOX* -,173,2005
intraperitoneal/cat lethal dose (50 percent kill): 2 mg/kgBJPCAL 1,287,1946
intraperitoneal/domestic animal lethal dose (50 percent kill): 3 mg/kgBJPCAL 1,287,1946
intraperitoneal/mouse lethal dose (50 percent kill): 3 mg/kgBJPCAL 1,287,1946
intraperitoneal/rabbit lethal dose (50 percent kill): 2500 µg/kgBJPCAL 1,287,1946

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lowest published toxic concentration: 2500 ppm/6H/28D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Other changes
FAATDF 14,776,1990
inhalation/mouse lowest published toxic concentration: 5 ppm/6H/14D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified)
FAATDF 14,776,1990
inhalation/mouse lowest published toxic concentration: 500 ppb/12W- intermittentEndocrine: Changes in spleen weight

Blood: Changes in spleen

Blood: Changes in leukocyte (WBC) count
TXAPA9 97,173,1989
inhalation/mouse lowest published toxic concentration: 2.5 ppm/10D- intermittentEndocrine: Changes in spleen weightNTPTR* ##TER87038
inhalation/rat lowest published toxic concentration: 2500 ppm/6H/14D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Other changes
FAATDF 14,776,1990
inhalation/rat lowest published toxic concentration: 500 ppm/6H/28D- intermittentEndocrine: Changes in spleen weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
FAATDF 14,776,1990
inhalation/rat lowest published toxic concentration: 500 ppm/6H/90D- intermittentEndocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count
FAATDF 14,776,1990
inhalation/rat lowest published toxic concentration: 0.3 mg/m3/24H/13W- continuousKidney, Ureter, and Bladder: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in leukocyte (WBC) count
VCVN5* -,92,1989
inhalation/rat lowest published toxic concentration: 2.5 ppm/10D- intermittentEndocrine: Changes in spleen weight

Blood: Changes in cell count (unspecified)
NTPTR* ##TER87038
inhalation/rat lowest published toxic concentration: 5 ppm/12D- intermittentBlood: Other changesNTPTR* ##TER87038
intraperitoneal/mouse lowest published toxic dose: 12 mg/kg/10D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldBJPCAL 1,287,1946
intraperitoneal/rabbit lowest published toxic dose: 5500 µg/kg/11D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldBJPCAL 1,287,1946

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.005 ppmDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 23,39,1980
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 100C,85,2012
TOXICOLOGY REVIEWNEJMAG 291,1171,1974
TOXICOLOGY REVIEWAMIHAB 21,132,1960
TOXICOLOGY REVIEWPTPAD4 1,189,1976
TOXICOLOGY REVIEWAJMEAZ 38,409,1965
TOXICOLOGY REVIEWJTEHD6 46,399,1995
TOXICOLOGY REVIEWENTOX* -,173,2005
TOXICOLOGY REVIEWREPTED 23,428,2007
TOXICOLOGY REVIEWHBTME* ,367,2007
TOXICOLOGY REVIEWHTOPA* 1,701,2002
TOXICOLOGY REVIEWBLREV* 3,71,1989
TOXICOLOGY REVIEWHTCWA* 2,109,

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.05 ppm (0.2 mg/m3)DTLVS* 3,16,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.05 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 ppm (0.16 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.05 ppm (0.2 mg/m3);KZW 0.25 ppm (1 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 ppm (0.16 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 ppm (0.03 mg/m3), carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.01 mg(As)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.05 ppm (0.2 mg/m3), VLE 0.2 ppm (0.8 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.2 mg/m3, short term exposure limit 0.8 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.01 ppm (0.03 mg(As)/m3), carc, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.01 ppm (0.032 mg/m3), MAY2012
Occupational Exposure Limit-JAPANceiling concentration 0.1 ppm (0.32 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.05 ppm (0.2 mg/m3), 2006
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg(As)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.05 ppm (0.2 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 ppm (0.16 mg/m3), JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.003 ppm (0.01 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,05 ppm (0,16 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.2 mg/m3, MAC(short term exposure limit) 0.6 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.02 ppm (0.05 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 ppm (0.16 mg/m3), JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.05 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.2 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.05 ppm (0.5 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.05 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.05 ppm (0.16 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.05 ppm (0.2 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.05 ppm (0.2 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.05 ppm (0.2 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.05 ppm (0.2 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSINE-airCarcinogen ceiling concentration 0.002 mg/m3/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 07580; Number of Industries 5; Total Number of Facilities 293; Number of Occupations 11; Total Number of Employees Exposed 3933; Total Number of Female Employees Exposed 1254
National Occupational Hazard Survey 1974Hazard Code 07580; Number of Industries 4; Total Number of Facilities 55; Number of Occupations 5; Total Number of Employees Exposed 586

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Arsine, 6001
NIOSH CURRENT INTELLIGENCE BULLETIN 32, 1979, BULLETIN 14, 1976, AND BULLETIN 23, 1978
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-125G
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