Arsine

RTECS #

CG6475000

CAS #

7784-42-1
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

77.95

Molecular Formula

AsH₃

Synonyms

Arsenic hydrid
Arsenic hydride
Arsenic trihydride
Arseniuretted hydrogen
Arsenous hydride
Arsenowodor (Polish)
Arsenwasserstoff (German)
Arsine (ACGIH:OSHA)
Hydrogen arsenide

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	Lowest published lethal concentration: 150 mg/m³/20M		HBAMAK 4,1306,1935
inhalation/Dog	lethal concentration (50 percent kill): 350 mg/m³/30M		NTIS** PB158-508
inhalation/Dog	lethal concentration (50 percent kill): 0.5 mg/m³/15M		VCVN5* -,87,1993
inhalation/domestic animal	lethal concentration (50 percent kill): 1 gm/m³/10M		NTIS** PB158-508
inhalation/frog	Lowest published lethal concentration: 4500 mg/m³/3H	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Altered sleep time (including change in righting reflex) Cardiac: Other changes	AEXPBL 80,288,1917
inhalation/human	Lowest published lethal concentration: 250 mg/m³/30M	Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Nausea or vomiting	HBTME* -,367,2007
inhalation/human	lowest published toxic concentration: 3 ppm	Blood: Pigmented or nucleated red blood cells Blood: Other hemolysis with or without anemia	AMIHAB 21,132,1960
inhalation/human	Lowest published lethal concentration: 25 ppm/30M	Blood: Other hemolysis with or without anemia Endocrine: Change in GH	AEHLAU 19,133,1969
inhalation/human	Lowest published lethal concentration: 300 ppm/5M		TABIA2 3,231,1933
inhalation/man	lowest published toxic concentration: 325 µg/m³	Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Hematuria	AEHLAU 34,224,1979
inhalation/monkey	Lowest published lethal concentration: 600 mg/m³/1H		HBAMAK 4,1306,1935
inhalation/mouse	lethal concentration (50 percent kill): 250 mg/m³/10M		NTIS** PB158-508
inhalation/mouse	lethal concentration (50 percent kill): 0.5 mg/m³/2M		VCVN5* -,87,1993
inhalation/mouse	lethal concentration (50 percent kill): 0.1 mg/m³/15M		VCVN5* -,87,1993
inhalation/mouse	lethal concentration (50 percent kill): 0.05 gm/m³/2H		TPKVAL 9,7,1967
inhalation/mouse	lethal concentration (50 percent kill): 17.2 ppm/2H		TPKVAL 9,7,1967
inhalation/mouse	Lowest published lethal concentration: 0.63 ppm/30M		TOXID9 72,160,2003
inhalation/mouse	Lowest published lethal concentration: 0.5 ppm/1H		TOXID9 72,160,2003
inhalation/mouse	Lowest published lethal concentration: 0.13 ppm/4H		TOXID9 72,160,2003
inhalation/mouse	Lowest published lethal concentration: 0.06 ppm/8H		TOXID9 72,160,2003
inhalation/rabbit	lethal concentration (50 percent kill): 200 ppm/10M		ENTOX* -,173,2005
inhalation/rabbit	lethal concentration (50 percent kill): 0.4 mg/m³/15M	Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia Gastrointestinal: Necrotic changes Kidney, Ureter, and Bladder: Hematuria	VCVN5* -,87,1993
inhalation/rabbit	lethal concentration (50 percent kill): 650 mg/m³/10M		NTIS** PB158-508
inhalation/rat	lethal concentration (50 percent kill): 0.3 mg/m³/15M		VCVN5* -,87,1993
inhalation/rat	lethal concentration (50 percent kill): 390 mg/m³/10M		NTIS** PB158-508
inhalation/rat	lethal concentration (50 percent kill): 240 ppm/30M	Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria Blood: Hemorrhage	ENTOX* -,173,2005
inhalation/rat	lethal concentration (50 percent kill): 178 ppm/1H	Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria Blood: Hemorrhage	ENTOX* -,173,2005
inhalation/rat	lethal concentration (50 percent kill): 45 ppm/4H	Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria Blood: Hemorrhage	ENTOX* -,173,2005
inhalation/rat	lethal concentration (50 percent kill): 120 ppm/10M	Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria Blood: Hemorrhage	ENTOX* -,173,2005
intraperitoneal/cat	lethal dose (50 percent kill): 2 mg/kg		BJPCAL 1,287,1946
intraperitoneal/domestic animal	lethal dose (50 percent kill): 3 mg/kg		BJPCAL 1,287,1946
intraperitoneal/mouse	lethal dose (50 percent kill): 3 mg/kg		BJPCAL 1,287,1946
intraperitoneal/rabbit	lethal dose (50 percent kill): 2500 µg/kg		BJPCAL 1,287,1946

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/hamster	lowest published toxic concentration: 2500 ppm/6H/28D- intermittent	Liver: Changes in liver weight Endocrine: Changes in spleen weight Blood: Other changes	FAATDF 14,776,1990
inhalation/mouse	lowest published toxic concentration: 5 ppm/6H/14D- intermittent	Liver: Changes in liver weight Endocrine: Changes in spleen weight Blood: Changes in other cell count (unspecified)	FAATDF 14,776,1990
inhalation/mouse	lowest published toxic concentration: 500 ppb/12W- intermittent	Endocrine: Changes in spleen weight Blood: Changes in spleen Blood: Changes in leukocyte (WBC) count	TXAPA9 97,173,1989
inhalation/mouse	lowest published toxic concentration: 2.5 ppm/10D- intermittent	Endocrine: Changes in spleen weight	NTPTR* ##TER87038
inhalation/rat	lowest published toxic concentration: 2500 ppm/6H/14D- intermittent	Liver: Changes in liver weight Endocrine: Changes in spleen weight Blood: Other changes	FAATDF 14,776,1990
inhalation/rat	lowest published toxic concentration: 500 ppm/6H/28D- intermittent	Endocrine: Changes in spleen weight Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	FAATDF 14,776,1990
inhalation/rat	lowest published toxic concentration: 500 ppm/6H/90D- intermittent	Endocrine: Changes in spleen weight Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count	FAATDF 14,776,1990
inhalation/rat	lowest published toxic concentration: 0.3 mg/m³/24H/13W- continuous	Kidney, Ureter, and Bladder: Other changes Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in leukocyte (WBC) count	VCVN5* -,92,1989
inhalation/rat	lowest published toxic concentration: 2.5 ppm/10D- intermittent	Endocrine: Changes in spleen weight Blood: Changes in cell count (unspecified)	NTPTR* ##TER87038
inhalation/rat	lowest published toxic concentration: 5 ppm/12D- intermittent	Blood: Other changes	NTPTR* ##TER87038
intraperitoneal/mouse	lowest published toxic dose: 12 mg/kg/10D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	BJPCAL 1,287,1946
intraperitoneal/rabbit	lowest published toxic dose: 5500 µg/kg/11D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	BJPCAL 1,287,1946

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.005 ppm	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Human Sufficient Evidence	IMEMDT 23,39,1980
International Agency for Research on Cancer (IARC)	Cancer Review:Group 1	IMEMDT 100C,85,2012
TOXICOLOGY REVIEW		NEJMAG 291,1171,1974
TOXICOLOGY REVIEW		AMIHAB 21,132,1960
TOXICOLOGY REVIEW		PTPAD4 1,189,1976
TOXICOLOGY REVIEW		AJMEAZ 38,409,1965
TOXICOLOGY REVIEW		JTEHD6 46,399,1995
TOXICOLOGY REVIEW		ENTOX* -,173,2005
TOXICOLOGY REVIEW		REPTED 23,428,2007
TOXICOLOGY REVIEW		HBTME* ,367,2007
TOXICOLOGY REVIEW		HTOPA* 1,701,2002
TOXICOLOGY REVIEW		BLREV* 3,71,1989
TOXICOLOGY REVIEW		HTCWA* 2,109,
TOXICOLOGY REVIEW		FCTOD7 107,406,2017
TOXICOLOGY REVIEW		RTOPDW 54,247,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.05 ppm (0.2 mg/m³)	DTLVS* 3,16,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 0.05 ppm (0.2 mg/m³), JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.05 ppm (0.16 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.05 ppm (0.2 mg/m³);KZW 0.25 ppm (1 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.05 ppm (0.16 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.01 ppm (0.03 mg/m³), carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.01 mg(As)/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.05 ppm (0.2 mg/m³), VLE 0.2 ppm (0.8 mg/m³), FEB2006
Occupational Exposure Limit-HUNGARY	time-weighted average 0.2 mg/m³, short term exposure limit 0.8 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.01 ppm (0.03 mg(As)/m³), carc, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.01 ppm (0.032 mg/m³), MAY2012
Occupational Exposure Limit-JAPAN	ceiling concentration 0.1 ppm (0.32 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.05 ppm (0.2 mg/m³), 2006
Occupational Exposure Limit-KOREA	time-weighted average 0.2 mg(As)/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.05 ppm (0.2 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.05 ppm (0.16 mg/m³), JAN2002
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.05 mg(As)/m³, carcinogen, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.003 ppm (0.01 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,05 ppm (0,16 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0.2 mg/m³, MAC(short term exposure limit) 0.6 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.1 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.02 ppm (0.05 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.05 ppm (0.16 mg/m³), JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 0.05 ppm (0.2 mg/m³), JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.2 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.05 ppm (0.5 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.05 ppm (0.2 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.05 ppm (0.16 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.05 ppm (0.2 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.05 ppm (0.2 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.05 ppm (0.2 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.05 ppm (0.2 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSINE-air	Carcinogen ceiling concentration 0.002 mg/m³/15M	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 07580; Number of Industries 5; Total Number of Facilities 293; Number of Occupations 11; Total Number of Employees Exposed 3933; Total Number of Female Employees Exposed 1254
National Occupational Hazard Survey 1974	Hazard Code 07580; Number of Industries 4; Total Number of Facilities 55; Number of Occupations 5; Total Number of Employees Exposed 586

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Arsine, 6001
NIOSH CURRENT INTELLIGENCE BULLETIN 32, 1979, BULLETIN 14, 1976, AND BULLETIN 23, 1978
NTP 14th Report on Carcinogens,2016:Known to be a human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-125G

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health