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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, N-methyl-

RTECS #

BY4550000

CAS #

100-61-8

Updated

September 2013

Molecular Weight

107.17

Molecular Formula

C7H9N

Synonyms

(Methylamino)benzene
Anilinomethane
Benzenamine, N-methyl- (9CI)
Methylaniline
Methylphenylamine
Monomethyl aniline (OSHA)
Monomethylaniline
N-Methyl aniline
N-Methylaminobenzene
N-Methylaniline (ACGIH)
N-Methylbenzenamine
N-Methylphenylamine
N-Monomethylaniline
N-Phenylmethylamine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster10 mmol/L/6H (+enzymatic activation step)MUREAV 517,187,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/cat lowest published lethal dose: 24 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
JIHTAB 31,1,1949
intravenous/rabbit lowest published lethal dose: 24 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
JIHTAB 31,1,1949
oral/guinea pig lowest published lethal dose: 1200 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
XPHBAO 271,16,1941
oral/rabbit lowest published lethal dose: 280 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
JIHTAB 31,1,1949
subcutaneous/guinea pig lowest published lethal dose: 1200 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
XPHBAO 271,16,1941

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 300 µg/m3/24H/14W- continuousBehavioral: Muscle contraction or spasticity

Liver: Liver function tests impaired

Blood: Methemoglobinemia- Carboxhemoglobinemia
GISAAA 34(3),7,1969

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 2 ppm (9 mg/m3) (skin)DTLVS* 3,174,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 2 ppm (9 mg/m3), Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 ppm (2.2 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 ppm (2 mg/m3);KZW 2 ppm (8 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 ppm (2.2 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (2.25 mg/m3), skin, MAY2011
Occupational Exposure Limit-FRANCEVME 0.5 ppm (2 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.5 ppm (2.2 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (2.25 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.5 ppm (2 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 2 ppm (9 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 ppm (2.2 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,5 ppm (2,2 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 2 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.2 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 ppm (2.2 mg/m3), KZG-week 1 ppm (4.4 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 2 ppm (9 mg/m3), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 ppm (2.2 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 2 ppm (9 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 2 ppm (9 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 2 ppm (9 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 2 ppm (9 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MONOMETHYL ANILINE-air10H time-weighted average 0.5 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X3740; Number of Industries 1; Total Number of Facilities 82; Number of Occupations 1; Total Number of Employees Exposed 82

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Monomethylaniline, 3511
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