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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, N-isopropyl-

RTECS #

BY4190000

CAS #

768-52-5

Updated

September 2013

Molecular Weight

135.23

Molecular Formula

C9H13N

Synonyms

N-Isopropylaniline
N-Isopropylaniline (ACGIH)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL mildNTIS** OTS0559504

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 1100 mg/m3/4HBehavioral: Somnolence (general depressed activity)NTIS** OTS0572512
intraperitoneal/mouse lethal dose (50 percent kill): 547 mg/kgNTIS** OTS0572513
oral/rat lethal dose (50 percent kill): 560 mg/kg85INA8 6,833,1991
skin/rabbit lethal dose (50 percent kill): 3550 mg/kg85INA8 6,833,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2800 µg/m3/6H/2W- intermittentBlood: Methemoglobinemia- CarboxhemoglobinemiaNTIS** OTS0572515

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppm (skin)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (11 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 ppm (10 mg/m3);KZW 4 ppm (20 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (11 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (10 mg/m3), skin, MAY2011
Occupational Exposure Limit-FRANCEVME 2 ppm (10 mg/m3), Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (10 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 2 ppm (10 mg/m3), skin, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (11 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2 ppm (11 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (11 mg/m3), JUL2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO N-ISOPROPYLANILINE-air10H time-weighted average 2 ppm (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #78
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