Acetic acid, vinyl ester

RTECS #

AK0875000

CAS #

108-05-4; 61891-42-7; 82041-23-4
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

86.10

Molecular Formula

C₄H₆O₂

Synonyms

1-Acetoxyethylene
Acetate de vinyle (French)
Acetic acid, ethenyl ester
Acetic acid, ethylene ether
Acetoxyethene
Ethanoic acid, ethenyl ester
Ethenyl acetate
Ethenyl ethanoate
Octan winylu (Polish)
VAC
Vinile (acetato di) (Italian)
Vinyl A monomer
Vinyl acetate
Vinyl acetate (ACGIH)
Vinyl acetate H.Q.
Vinyl ethanoate
Vinylacetaat (Dutch)
Vinylacetat (German)
Vinyle (acetate de) (French)
Vinylester kyseliny octove (Czech)
VYAC
Zeset T

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	22 ppm		AIHAAP 30,449,1969

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lymphocyte/human	250 µmol/L	MUREAV 159,109,1986
micronucleus test	intraperitoneal/mouse	1 gm/kg	MUREAV 190,41,1987
micronucleus test	lymphocyte/human	500 µmol/L	MUREAV 190,41,1987
morphological transform	embryo/hamster	62500 µg/L	AETODY 1,241,1980
sister chromatid exchange	ovary/hamster	125 µmol/L	CNREA8 45,4816,1985
sister chromatid exchange	lymphocyte/human	100 µmol/L	CNREA8 45,4816,1985
sperm morphology	intraperitoneal/mouse	2500 mg/kg/5D	MUREAV 202,171,1988

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	1000 ppm/6H (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	FAATDF 24,198,1995
oral/rat	500 mg/kg (multigenerations)	Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	EPASR* 8EHQ-0185-0543
oral/rat	91 gm/kg (multigeneration)	Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	FAATDF 24,206,1995
oral/rat	4770 mg/kg (6-15D pregnant)	Reproductive: Other effects on female	NTIS** OTS0535164

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 600 ppm/6H/5D/2Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors	EPASR* 8EHQ-0187-0650
inhalation/rat	lowest published toxic concentration: 600 ppm/6H/5D/2Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Olfaction: Tumors	EPASR* 8EHQ-0187-0650
oral/rat	lowest published toxic dose: 100 gm/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Endocrine: Thyroid tumors Reproductive: Tumorigenic effects: Uterine tumors	TXAPA9 68,43,1983

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lethal concentration (50 percent kill): 6200 ppm/4H		NTIS** OTS0521596
inhalation/mouse	lethal concentration (50 percent kill): 1550 ppm/4H		DUPON* ES-3574,1975
inhalation/rabbit	lethal concentration (50 percent kill): 2500 ppm/4H		85INA8 5,621,1986
inhalation/rat	lethal concentration (50 percent kill): 11400 mg/m³/4H		GTPZAB 25(11),57,1981
intraperitoneal/guinea pig	lowest published lethal dose: 500 mg/kg	Liver: Fatty liver degeneration	AIHAAP 35,21,1974
oral/mouse	lethal dose (50 percent kill): 1600 mg/kg		NTIS** OTS0521596
oral/rat	lethal dose (50 percent kill): 2900 mg/kg		NTIS** OTS0521596
skin/rabbit	lethal dose (50 percent kill): 2335 mg/kg		DUPON* ES-3574,1975

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 1000 ppm/6H/13W- intermittent	Lung, Thorax, or Respiration: Other changes Lung, Thorax, or Respiration: Changes in lung weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0521599
inhalation/mouse	lowest published toxic concentration: 600 ppm/6H/2Y- intermittent	Lung, Thorax, or Respiration: Other changes	NTIS** OTS0521599
inhalation/rat	lowest published toxic concentration: 600 ppm/6H/4W- intermittent	Olfaction: Other olfaction effects	INHTE5 9,331,1997
inhalation/rat	lowest published toxic concentration: 250 ppm/6H/15D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0521599
inhalation/rat	lowest published toxic concentration: 1000 ppm/6H/13W- intermittent	Lung, Thorax, or Respiration: Changes in lung weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0521599
inhalation/rat	lowest published toxic concentration: 2500 ppm/4H/1Y- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0521599
oral/mouse	lowest published toxic dose: 6300 mg/kg/20W- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	GISAAA 31(8),19,1966
oral/mouse	lowest published toxic dose: 18400 mg/kg/92D- continuous	Behavioral: Fluid intake	TOXID9 60,439,2001
oral/rat	lowest published toxic dose: 21 mg/kg/30W- intermittent	Behavioral: Alteration of classical conditioning	GISAAA 31(8),19,1966
oral/rat	lowest published toxic dose: 46000 mg/kg/92D- continuous	Behavioral: Fluid intake Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOXID9 60,439,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 10 ppm;short term exposure limit 15 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 63,443,1995
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 39,113,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 39,113,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 63,443,1995
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMSUDL 7,56,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMEMDT 63,443,1995
TOXICOLOGY REVIEW		ARPTDI 43,485,2003
TOXICOLOGY REVIEW		TOLED5 138,9,2003
TOXICOLOGY REVIEW		TOLED5 140-141,43,2003
TOXICOLOGY REVIEW		TOLED5 140-141,83,2003
TOXICOLOGY REVIEW		MUREAV 567,227,2004
TOXICOLOGY REVIEW		MUREAV 567,109,2004
TOXICOLOGY REVIEW		MUTAEX 20,389,2005
TOXICOLOGY REVIEW		ENTOX* -,434,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		HUTOX* -,649,1996
TOXICOLOGY REVIEW		MUREAV 682,94,2009
TOXICOLOGY REVIEW		FCTOD7 49,1877,2011
TOXICOLOGY REVIEW		FCTOD7 55,596,2013
TOXICOLOGY REVIEW		RTOPDW 55,43,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 10 ppm (30 mg/m³)	DTLVS* 3,276,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 ppm (35 mg/m³), short term exposure limit 20 ppm (70 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 10 ppm (35 mg/m³);KZW 20 ppm (70 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 10 ppm (36 mg/m³), short term exposure limit 15 ppm (54 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 10 ppm (30 mg/m³), carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 5 ppm (18 mg/m³), short term exposure limit 10 ppm (35 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 10 ppm (30 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 10 ppm (30 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	2B carc, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 10 ppm (30 mg/m³), short term exposure limit 20 ppm (60 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 ppm (30 mg/m³);short term exposure limit 20 ppm (60 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 ppm (35 mg/m³), short term exposure limit 20 ppm (70 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 10 ppm (35 mg/m³); short term exposure limit 15 ppm (53 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 10 mg/m³, MAC(short term exposure limit) 30 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 10 mg/m³, short term exposure limit 30 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 5 ppm (18 mg/m³);short term exposure limit 10 ppm (35 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 10 ppm (35 mg/m³), carc 3, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 18 mg/m³, 2003
Occupational Exposure Limit-TURKEY	time-weighted average 10 ppm (30 mg/m³), JAN1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL ACETATE-air	ceiling concentration 4 ppm/15M	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code X6624; Number of Industries 79; Total Number of Facilities 6264; Number of Occupations 71; Total Number of Employees Exposed 129024; Total Number of Female Employees Exposed 36642
National Occupational Hazard Survey 1974	Hazard Code 76420; Number of Industries 62; Total Number of Facilities 5046; Number of Occupations 59; Total Number of Employees Exposed 50282

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110898/AS)
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Vinyl acetate, 1453
On EPA IRIS database
OSHA ANALYTICAL METHOD #51

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health