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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic anhydride

RTECS #

AK1925000

CAS #

108-24-7

Updated

April 2015

Molecular Weight

102.10

Molecular Formula

C4H6O3

Synonyms

Acetanhydride
Acetic acid, anhydride (9CI)
Acetic anhydride (ACGIH:OSHA)
Acetic oxide
Acetyl anhydride
Acetyl ether
Acetyl oxide
Anhydrid kyseliny octove (Czech)
Anhydride acetique (French)
Anidride acetica (Italian)
Azijnzuuranhydride (Dutch)
Essigsaeureanhydrid (German)
Ethanoic anhydrate
Octowy bezwodnik (Polish)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 540 mg open irritation test mildUCDS** 8/7/1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 6.3 gm/L/3HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 20 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 27,174,2013
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 6.2 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 4.0 gm/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,174,2013
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 1.8 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 2.0 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 27,174,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 1.5 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
inhalation/rat lethal concentration (50 percent kill): 1000 ppm/4H34ZIAG -,607,1969
oral/rat lethal dose (50 percent kill): 1780 mg/kgAMIHBC 4,119,1951
skin/rabbit lethal dose (50 percent kill): 4 mL/kgUCDS** 8/7/1963

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2470 µg/m3/24H/95D- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 34(4),103,1969
inhalation/rat lowest published toxic concentration: 400 ppm/6H/2W- intermittentEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0556144

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppm;short term exposure limit 3 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDair-ceiling concentration 5 ppm (20 mg/m3)DTLWS* 3,2,1971
Occupational Exposure Limit-AUSTRALIAceiling concentration 5 ppm (21 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (20 mg/m3);KZW 10 ppm (40 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (21 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 5 ppm (20 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 5 ppm (21 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVLE 5 ppm (20 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 5 ppm (21 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 20 mg/m3, short term exposure limit 20 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDshort term exposure limit 5 ppm (20 mg/m3), NOV2011
Occupational Exposure Limit-JAPANceiling concentration 5 ppm (21 mg/m3), MAY2012
Occupational Exposure Limit-KOREAceiling concentration 5 ppm (20 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 ppm (20 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 5ppm (21 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (21 mg/m3), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 10 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 3 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENceiling concentration 5 ppm (20 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 5 ppm (20 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 ppm (2.5 mg/m3);short term exposure limit 2 ppm, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 ppm (20 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 ppm (20 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 ppm (20 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 ppm (20 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETIC ANHYDRIDE-airceiling concentration 5 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 02740; Number of Industries 73; Total Number of Facilities 7514; Number of Occupations 59; Total Number of Employees Exposed 92428; Total Number of Female Employees Exposed 11630
National Occupational Hazard Survey 1974Hazard Code 02740; Number of Industries 23; Total Number of Facilities 3012; Number of Occupations 16; Total Number of Employees Exposed 19365

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acetic anhydride, 3506
OSHA ANALYTICAL METHOD #102
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