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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, propyl ester

RTECS #

AJ3675000

CAS #

109-60-4

Updated

September 2013

Molecular Weight

102.15

Molecular Formula

C5H10O2

Synonyms

1-Acetoxypropane
1-Propyl acetate
Acetate de propyle normal (French)
Acetic acid n-propyl ester
n-Propyl acetate
n-Propyl acetate (ACGIH:OSHA)
Octan propylu (Polish)
Propyl acetate
Propylester kyseliny octove (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,355,1986
skin /rabbit 500 mg open irritation test mildUCDS** 1/25/1965

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 38 gm/m3/5HBehavioral: General anesthetic

Gastrointestinal: Changes in structure or function of salivary glands

Blood: Other changes
AGGHAR 5,1,1933
inhalation/human lowest published toxic concentration: 1000 mg/m3Eye: Lacrimation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes
AGGHAR 5,1,1933
inhalation/rat Lowest published lethal concentration: 8000 ppm/4HAIHAAP 30,470,1969
intraperitoneal/mouse lethal dose (50 percent kill): 1420 mg/kgSCCUR* -,8,1961
oral/mouse lethal dose (50 percent kill): 8300 mg/kgBehavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
FCTXAV 2,327,1964
oral/rabbit lethal dose (50 percent kill): 6640 mg/kgIMSUAI 41,31,1972
oral/rat lethal dose (50 percent kill): 9370 mg/kgBehavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
FCTXAV 2,327,1964
skin/rabbit lethal dose (50 percent kill): >20 mL/kgUCDS** 1/25/1965
subcutaneous/cat lowest published lethal dose: 3 gm/kgBehavioral: Somnolence (general depressed activity)AGGHAR 5,1,1933
subcutaneous/guinea pig lowest published lethal dose: 3 gm/kgBehavioral: Somnolence (general depressed activity)AGGHAR 5,1,1933

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 200 ppm;short term exposure limit 250 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAMIHAB 21,28,1960

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 200 ppm (840 mg/m3)DTLVS* 3,216,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 200 ppm (835 mg/m3), short term exposure limit 250 ppm (1040 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 200 ppm (847 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 250 ppm (1055 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 150 ppm (625 mg/m3), MAY2011
Occupational Exposure Limit-FRANCEVME 200 ppm (840 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 100 ppm (420 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 840 mg/m3, short term exposure limit 840 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 150 ppm (625 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 200 ppm (830 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 200 ppm (840 mg/m3), short term exposure limit 250 ppm (1050 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 200 ppm (840 mg/m3);short term exposure limit 250 ppm (1050 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 200 ppm (835 mg/m3), short term exposure limit 250 ppm (1040 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 100 ppm (420 mg/m3), JAN1999
Occupational Exposure Limit-NORWAYtime-weighted average 0.001 mg(Rh)/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 200 ppm (835 mg/m3); short term exposure limit 250 ppm (1044 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 200 mg/m3, MAC(short term exposure limit) 1000 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 200 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 100 ppm (400 mg/m3);short term exposure limit 200 ppm (800 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 100 ppm (420 mg/m3), KZG-week 200 ppm (840 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 420 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 mg(Rh)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 200 ppm (840 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 200 ppm (840 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 200 ppm (849 mg/m3);short term exposure limit 250 ppm (1060 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 200 ppm (840 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 200 ppm (840 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 200 ppm (840 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 200 ppm (840 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-PROPYL ACETATE-air10H time-weighted average 200 ppm;short term exposure limit 250 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 63265; Number of Industries 34; Total Number of Facilities 3859; Number of Occupations 42; Total Number of Employees Exposed 46856; Total Number of Female Employees Exposed 11660
National Occupational Hazard Survey 1974Hazard Code 63265; Number of Industries 38; Total Number of Facilities 1960; Number of Occupations 48; Total Number of Employees Exposed 32970

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450
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