Multisystem Inflammatory Syndrome (MIS)

The Council of State and Territorial Epidemiologists (CSTE) and CDC have developed a new CSTE/CDC MIS-C surveillance case definition, corresponding case report form [441 KB, 3 pages], and case report form guidance document [329 KB, 10 pages] to be used starting January 1, 2023. MIS-C cases with illness onset before January 1, 2023, but reported after January 1, 2023, will be assigned using the 2020 CDC MIS-C case definition but reported using the new case report form. An interim case reporting guidance document [181 KB, 4 pages] will be provided for these cases. After January 1, 2023, CDC MIS-C webpages will be updated.

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MIS and COVID-19

CDC is investigating multisystem inflammatory syndrome in children and adults, a rare but serious condition associated with COVID-19.

About MIS

What is MIS?

Multisystem inflammatory syndrome (MIS) can affect children (MIS-C) and adults (MIS-A). MIS is a rare but serious condition associated with COVID-19 in which different body parts become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs.

If you or someone in your household is showing any emergency warning signs, seek emergency medical care immediately.